The American Journal of Medicine
Volume 121, Issue 11 , Pages 966-973 , November 2008

Dramatic Reversal of Derangements in Muscle Metabolism and Left Ventricular Function After Bariatric Surgery

  • Joshua G. Leichman, MD

      Affiliations

    • Department of Internal Medicine, The University of Texas Health Science Center at Houston
    • ,
  • Erik B. Wilson, MD

      Affiliations

    • Department of Surgery, The University of Texas Health Science Center at Houston
    • ,
  • Terry Scarborough, MD

      Affiliations

    • Department of Surgery, The University of Texas Health Science Center at Houston
    • ,
  • David Aguilar, MD

      Affiliations

    • Department of Internal Medicine, The University of Texas Health Science Center at Houston
    • ,
  • Charles C. Miller III, PhD

      Affiliations

    • Department of Cardiovascular and Thoracic Surgery, The University of Texas Health Science Center at Houston
    • ,
  • Sherman Yu, MD

      Affiliations

    • Department of Surgery, The University of Texas Health Science Center at Houston
    • ,
  • Mohamed F. Algahim, BSc

      Affiliations

    • Department of Internal Medicine, The University of Texas Health Science Center at Houston
    • ,
  • Manuel Reyes, MD

      Affiliations

    • Department of Internal Medicine, The University of Texas Health Science Center at Houston
    • ,
  • Frank G. Moody, MD

      Affiliations

    • Department of Surgery, The University of Texas Health Science Center at Houston
    • ,
  • Heinrich Taegtmeyer, MD, DPhil

      Affiliations

    • Department of Internal Medicine, The University of Texas Health Science Center at Houston
    • Corresponding Author InformationRequests for reprints should be addressed to Heinrich Taegtmeyer, MD, DPhil, University of Texas Houston Medical School, Department of Medicine/Cardiology, 6431 Fannin, MSB 1.246, Houston, TX 77030

  • Image Result

    Oil-red-O stain of muscle biopsies. Samples were obtained at baseline and 3 and 9 months after surgery. The slides are representative of 4 sections for each patient at each of the time points (baselin

    Oil-red-O stain of muscle biopsies. Samples were obtained at baseline and 3 and 9 months after surgery. The slides are representative of 4 sections for each patient at each of the time points (baseline and 3 and 9 months). Baseline versus 3 months 4.2 arbitrary units (−2.4-10.9; P<.2). Three months versus 9 months 8.7 arbitrary units (2.4-15.1; P<.009). See text for further details.

  • Image Result
    Transcript levels of metabolically relevant enzymes. A, mRNA levels of PDK4. *P < .0001 time point versus baseline. **P<.001, 3 months versus 9 months. B, mRNA levels of SCD1. *P<.0001, time poi

    Transcript levels of metabolically relevant enzymes. A, mRNA levels of PDK4. *P < .0001 time point versus baseline. **P<.001, 3 months versus 9 months. B, mRNA levels of SCD1. *P<.0001, time point versus baseline. C, mRNA levels of PPAR-α–regulated genes. *P<.05, baseline versus 9 months; **P<.05, 3 months versus 9 months. PPAR-α=peroxisome proliferator activating receptor-α; CPT1=carnitine phosphatidyl transferase 1; MCAD=medium chain acetyl-CoA dehydrogenase. See text for further details.

 Supported by the National Heart, Lung, and Blood Institute of the US Public Health Service (R01HL73162 and M01 RR02558). None of the authors of this work have any financial conflicts of interest to disclose. All authors had access to the data and a role in writing the article.

 Clinical Trials Registry: ClinicalTrials.gov Identifier: NCT00178633; http:/www.clinicaltrials.gov

PII: S0002-9343(08)00756-0

doi: 10.1016/j.amjmed.2008.06.033

The American Journal of Medicine
Volume 121, Issue 11 , Pages 966-973 , November 2008

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