The American Journal of Medicine
Volume 121, Issue 11 , Pages 943-948 , November 2008

Individualized Treatment for Iron-deficiency Anemia in Adults

  • Michael Alleyne, MD

      Affiliations

    • The National Cancer Institute, National Institutes of Health, Bethesda, Md
    • The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md
    • ,
  • McDonald K. Horne, MD

      Affiliations

    • Hematology Service and Department of Laboratory Medicine, WG Magnuson Clinical Center, National Institutes of Health, Bethesda, Md
    • ,
  • Jeffery L. Miller, MD

      Affiliations

    • The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md
    • Corresponding Author InformationReprint requests should be addressed to Jeffery L. Miller, MD, Chief, Section on Molecular Genomics and Therapeutics, Molecular Medicine Branch, NIDDK, National Institutes of Health, Building 10, Room 9N311, 10 Center Drive, Bethesda, MD 20892-1801

References 

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  2. United Nations Sub-Committee on Nutrition (ACC/SCN). “Fourth report on the world nutrition situation.”. United Nations 2000;
  3. Centers for Disease Control and Prevention. “Recommendations to prevent and control iron deficiency in the United States.”. MMWR Morb Mortal Wkly Rep. 1998;47(RR-3):1–29
  4. Looker AC, Dallman PR, Carroll MD, et al. Prevalence of iron deficiency in the United States. JAMA. 1997;277:973–976
  5. Heeney MM, Andrews NC. Iron homeostasis and inherited iron overload disorders: an overview. Hematol Oncol Clin North Am. 2004;18:1379–1403
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  7. Farley PC, Foland J. Iron deficiency anemia (How to diagnose and correct). Postgrad Med. 1990;87:89–101
  8. Cook JD. Diagnosis and management of iron-deficiency anaemia. Best Pract Res Clin Haematol. 2005;18:319–332
  9. Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, DC: National Academy Press; 2001;
  10. Love AL, Billett HH. Obesity, bariatric surgery, and iron deficiency: True, true, true and related. Am J Hematol. 2008;83:403–409
  11. Crosby WH. The rationale for treating iron deficiency anemia. Arch Intern Med. 1984;144:471–472
  12. Beutler E. Disorders of iron metabolism. In: Williams Hematology. Chapter 40. Seventh Edition. McGraw-Hill; :511-553.
  13. Provan D. Mechanisms and management of iron deficiency anemia. Br J Haematol. 1999;105(Suppl 1):19–26
  14. In:  Stang J,  Story M editor. Guidelines for Adolescent Nutrition Services. 2005;
  15. Cook JD. Iron-deficiency anemia. Baillieres Clin Haematol. 1994;7:787–804
  16. Massey A. Microcytic anemia (Differential diagnosis and management of iron deficiency anemia). Med Clin North Am. 1992;76:549–565
  17. Rimon E, Kagansky N, Kagansky M, et al. Are we giving too much iron? (Low-dose iron therapy is effective in octogenarians). Am J Med. 2005;118:1142–1147
  18. Bonnar J, Goldberg A, Smith JA. Do pregnant women take their iron?. Lancet. 1969;1:457–458
  19. Beutler E, Hoffbrand AV, Cook JD. Iron deficiency and overload. Hematology Am Soc Hematol Educ Program. 2003;40-61:
  20. Wiltink WF, Ybema HJ, Leijnse B, Gerbrandy J. The iron tolerance test (Measurement of absorption and utilization of a therapeutic dose of iron). Clin Chim Acta. 1966;13:701–707
  21. Hershko C, Hoffbrand AV, Keret D, et al. A Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica. 2005;90:585–595
  22. Goroll AH, Mulley AG. Office evaluation and management of the adult patient. Prim Care. 82:607-608.
  23. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood. 2003;101:3359–3364

 Funding: This research was supported by the Intramural Research Program of the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.

 All authors had access to the data, a role in writing the article, and no conflicts of interest.

PII: S0002-9343(08)00703-1

doi: 10.1016/j.amjmed.2008.07.012

The American Journal of Medicine
Volume 121, Issue 11 , Pages 943-948 , November 2008

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