The American Journal of Medicine
Volume 121, Issue 11 , Pages 989-996 , November 2008

Incidental Pulmonary Nodules on Cardiac Computed Tomography: Prognosis and Use

  • Carlos Iribarren, MD, MPH, PhD

      Affiliations

    • Division of Research, Kaiser Permanente of Northern California, Oakland, Calif
    • Department of Epidemiology, Biostatistics and Medicine, University of California, San Francisco, Calif
    • Corresponding Author InformationRequests for reprints should be addressed to Carlos Iribarren, MD, MPH, PhD, Research Scientist, Kaiser Permanente, Division of Research, 2000 Broadway, Oakland, CA 94612
    • ,
  • Mark A. Hlatky, MD

      Affiliations

    • Department of Medicine, Stanford University School of Medicine, Stanford, Calif
    • Department of Health Research and Policy, Stanford University School of Medicine, Stanford, Calif
    • ,
  • Malini Chandra, MS

      Affiliations

    • Division of Research, Kaiser Permanente of Northern California, Oakland, Calif
    • ,
  • Joan M. Fair, ANP, PhD

      Affiliations

    • Stanford Prevention Research Center, Stanford University, Stanford, Calif
    • ,
  • Geoffrey D. Rubin, MD

      Affiliations

    • Department of Radiology, Stanford University School of Medicine, Stanford, Calif
    • ,
  • Alan S. Go, MD

      Affiliations

    • Division of Research, Kaiser Permanente of Northern California, Oakland, Calif
    • Department of Epidemiology, Biostatistics and Medicine, University of California, San Francisco, Calif
    • ,
  • Jeremy R. Burt, MD

      Affiliations

    • Department of Radiology, Johns Hopkins Hospital, Baltimore, Md
    • ,
  • Stephen P. Fortmann, MD

      Affiliations

    • Department of Medicine, Stanford University School of Medicine, Stanford, Calif
    • Stanford Prevention Research Center, Stanford University, Stanford, Calif
    • ,
  • Atherosclerotic Disease, Vascular Function and Genetic Epidemiology Study

References 

  1. Elgin EE, O'Malley PG, Feuerstein I, Taylor AJ. Frequency and severity of “incidentalomas” encountered during electron beam computed tomography for coronary calcium in middle-aged army personnel. Am J Cardiol. 2002;90:543–545
  2. Horton KM, Post WS, Blumenthal RS, Fishman EK. Prevalence of significant noncardiac findings on electron-beam computed tomography coronary artery calcium screening examinations. Circulation. 2002;106:532–534
  3. Hunold P, Schmermund A, Seibel RM, et al. Prevalence and clinical significance of accidental findings in electron-beam tomographic scans for coronary artery calcification. Eur Heart J. 2001;22:1748–1758
  4. Schragin JG, Weissfeld JL, Edmundowicz D, et al. Non-cardiac findings on coronary electron beam computed tomography scanning. J Thorac Imaging. 2004;19:82–86
  5. MacMahon H, Austin JH, Gamsu G, et al. Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society. Radiology. 2005;237:395–400
  6. Burt JR, Iribarren C, Fair JM, et al. Atherosclerotic Disease, Vascular Function and Genetic Epidemiology (ADVANCE) Study Incidental findings on cardiac multi-detector row computed tomography among healthy older adults: prevalence and clinical correlates. Arch Intern Med. 2008;168:756–761
  7. Fair JM, Kiazand A, Varady A, et al. Ethnic differences in coronary artery calcium in a healthy cohort aged 60 to 69 years. Am J Cardiol. 2007;100:981–985
  8. Iribarren C, Husson G, Go AS, et al. Plasma leptin levels and coronary artery calcification in older adults. J Clin Endocrinol Metab. 2007;92:729–732
  9. Taylor-Piliae RE, Norton LC, Haskell WL, et al. Validation of a new brief physical activity survey among men and women aged 60-69 years. Am J Epidemiol. 2006;164:598–606
  10. Peuchot M, Libshitz HI. Pulmonary metastatic disease: radiologic-surgical correlation. Radiology. 1987;164:719–722
  11. Tan BB, Flaherty KR, Kazerooni EA, Iannettoni MD. The solitary pulmonary nodule. Chest. 2003;123(Suppl 1):89S–96S
  12. Benjamin MS, Drucker EA, McLoud TC, Shepard JA. Small pulmonary nodules: detection at chest CT and outcome. Radiology. 2003;226:489–493
  13. Jin SM, Choi SH, Yoo CG, et al. Small solid noncalcified pulmonary nodules detected by screening chest computed tomography. Respir Med. 2007;101:1880–1884

 This study was supported by a grant from the Kaiser Permanente Community Benefit Program; the ADVANCE Study was originally funded by the Donald W. Reynolds Foundation (Las Vegas, Nevada).

 Conflicts of Interest: None.

PII: S0002-9343(08)00663-3

doi: 10.1016/j.amjmed.2008.05.040

The American Journal of Medicine
Volume 121, Issue 11 , Pages 989-996 , November 2008

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