The American Journal of Medicine
Volume 121, Issue 10 , Pages 903-908 , October 2008

Primary Syphilis: Serological Treatment Response to Doxycycline/Tetracycline versus Benzathine Penicillin

  • Tom Wong, MD, MPH

      Affiliations

    • Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    • ,
  • Ameeta E. Singh, BMBS, MSc

      Affiliations

    • Alberta Health and Wellness, Edmonton, Canada
    • Department of Medicine, University of Alberta, Edmonton, Canada
    • Corresponding Author InformationRequests for reprints should be addressed to Ameeta Singh, BMBS, MSc, Infectious Diseases Consultant, Alberta Health and Wellness, P.O. Box 1360 Stn Main, 10025 Jasper Ave., Edmonton, AB T5J 2N3, Canada
    • ,
  • Prithwish De, MHSc, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada

References 

  1. Public Health Agency of Canada. Reported cases of STI from January 1 to June 30, 2006 and January 1 to June 30, 2005 and corresponding rates for January 1 to December 31, 2005 and 2006. http://www.phac-aspc.gc.ca/std-mts/stdcases-casmts/cases-cas-07_e.htmAccessed June 12, 2007
  2. Public Health Agency of Canada. Canadian Guidelines on Sexually Transmitted Infections 2006. Ottawa, ON: Public Health Agency of Canada; 2006;
  3. Workowski KA, Berman SM Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep. 2006;55(RR-11):1–94
  4. Standiford HC. Tetracyclines and chloramphenicol. In:  Mandell GL,  Douglas RG,  Bennett JE editor. Priniciples and Practice of Infectious Diseases. 6th edition. Philadelphia, PA: Elsevier Churchill Livingstone; 2005;p. 356–373
  5. Abramson IJ, Smibert RM. Inhibition of growth of treponemes by antimicrobial agents. Br J Vener Dis. 1971;47:407–412
  6. Abramson IJ, Smibert RM. Bactericidal activity of antimicrobial agents for treponemes. Br J Vener Dis. 1971;47:413–418
  7. Harshan V, Jayakumar W. Doxycycline in early syphilis: a long term follow up. Indian J Dermatol. 1982;27:119–124
  8. Onoda Y. Therapeutic effect of oral doxycycline on syphilis. Br J Vener Dis. 1979;55:110–115
  9. Ghanem KG, Erbelding EJ, Cheng WW, Rompalo AM. Doxycycline compared with benzathine penicillin for the treatment of early syphilis. Clin Infect Dis. 2006;42:e45–e49
  10. Cunha BA, Sibley CM, Ristuccia AM. Doxycycline. Ther Drug Monit. 1982;4:115–135
  11. Rajam RV, Rangiah RN, Somini C, Krishnamoorthy C. Tetracycline in venereal diseases. Antiseptic Madras. 1956;53:9–19
  12. Schroeter AL, Lucas JB, Price EV, Falcone VH. Treatment for early syphilis and reactivity of serologic tests. JAMA. 1972;221:471–476
  13. Fiumara NJ, Babinski PL. Reinfection annular secondary syphilis: a case report. Sex Transm Dis. 1978;5:160–162
  14. Fiumara NJ. Treatment of primary and secondary syphilis (Serological response). JAMA. 1980;243:2500–2502
  15. Brown ST, Zaidi A, Larsen SA, Reynolds GH. Serological response to syphilis treatment (A new analysis of old data). JAMA. 1985;253:1296–1299
  16. Larsen SA, Steiner BM, Rudolph AH. Laboratory diagnosis and interpretation of tests for syphilis. Clin Microbiol Rev. 1995;8:1–21
  17. Romanowski B, Sutherland R, Fick GH, et al. Serologic response to treatment of infectious syphilis. Ann Intern Med. 1991;114:1005–1009
  18. Statistics Canada. Canadian Population Census, 2006. Ottawa, ON: Statistics Canada; 2007;
  19. Rolfs RT. Treatment of syphilis, 1993. Clin Infect Dis. 1995;20(Suppl 1):S23–S38
  20. Riedner G, Rusizoka M, Todd J, et al. Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. N Engl J Med. 2005;353:1236–1244
  21. Goh BT, van Voorst Vader PC. European guideline for the management of syphilis. Int J STD AIDS. 2001;12(Suppl 3):14–26

 This study was supported by funding from Alberta Health and Wellness and from the Public Health Agency of Canada, and approved by the University of Alberta Health Research and Ethics Board.

PII: S0002-9343(08)00610-4

doi: 10.1016/j.amjmed.2008.04.042

The American Journal of Medicine
Volume 121, Issue 10 , Pages 903-908 , October 2008

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