The American Journal of Medicine
Volume 121, Issue 10, Supplement 1 , Pages S9-S14 , October 2008

Cardiovascular Morbidity and Mortality in Rheumatoid Arthritis

  • Sherine E. Gabriel, MD

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Sherine E. Gabriel, MD, Professor of Medicine, Professor of Epidemiology Mayo Clinic College of Medicine Chair, Department of Health Sciences Research Mayo Clinic 200 First Street SW Rochester, MN 55905 Phone: 507-284-1696

References 

  1. Watson DJ, Rhodes T, Guess HA. All-cause mortality and vascular events among patients with rheumatoid arthritis, osteoarthritis, or no arthritis in the UK General Practice Research Database. J Rheumatol. 2003;30:1196–1202
  2. Kvalvik AG, Jones MA, Symmons DP. Mortality in a cohort of Norwegian patients with rheumatoid arthritis followed from 1977 to 1992. Scand J Rheumatol. 2000;29:29–37
  3. Symmons DP, Jones MA, Scott DL, et al. Longterm mortality outcome in patients with rheumatoid arthritis: early presenters continue to do well. J Rheumatol. 1998;25:1072–1077
  4. Anderson ST. Mortality in rheumatoid arthritis: do age and gender make a difference?. Semin Arthritis Rheum. 1996;25:291–296
  5. Cobb S, Anderson F, Bauer W. Length of life and cause of death in rheumatoid arthritis. N Engl J Med. 1953;249:553–556
  6. Myllykangas-Luosujarvi RA, Aho K, Isomaki HA. Mortality in rheumatoid arthritis. Semin Arthritis Rheum. 1995;25:193–202
  7. Gonzalez-Gay MA, Gonzalez-Juanatey C, Miranda-Filloy JA, et al. Cardiovascular disease in rheumatoid arthritis. Biomedicine and Pharmacotherapy. 2006;60:673–677
  8. Solomon DH, Goodson NJ, Katz JN, et al. Patterns of cardiovascular risk in rheumatoid arthritis. Ann Rheum Dis. 2006;65:1608–1612
  9. Maradit-Kremers H, Crowson CS, Nicola PJ, et al. Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum. 2005;52:402–411
  10. Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr. 2006;83:456S–460S
  11. Melton LJ. History of the Rochester Epidemiology Project. Mayo Clin Proc. 1996;71:266–274
  12. Nicola PJ, Crowson CS, Maradit-Kremers H, et al. Contribution of congestive heart failure and ischemic heart disease to excess mortality in rheumatoid arthritis. Arthritis Rheum. 2006;54:60–67
  13. Crowson CS, Nicola PJ, Kremers HM, et al. How much of the increased incidence of heart failure in rheumatoid arthritis is attributable to traditional cardiovascular risk factors and ischemic heart disease?. Arthritis Rheum. 2005;52:3039–3044
  14. Gabriel SE, Crowson CS, Kremers HM, et al. Survival in rheumatoid arthritis: a population-based analysis of trends over 40 years. Arthritis Rheum. 2003;48:54–58
  15. Maradit-Kremers H, Nicola PJ, Crowson CS, et al. Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum. 2005;52:722–732
  16. Wallberg-Jonsson S, Ohman ML, Dahlqvist SR. Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in Northern Sweden. J Rheumatol. 1997;24:445–451
  17. Goodson NJ, Wiles NJ, Lunt M, et al. Mortality in early inflammatory polyarthritis: cardiovascular mortality is increased in seropositive patients. Arthritis Rheum. 2002;46:2010–2019
  18. Gonzalez A, Maradit-Kremers H, Crowson CS, et al. The incidence of cardiovascular risk factors in rheumatoid arthritis. [abstract] Arthritis Rheum. 2005;54:S785
  19. Wolfe F, Freundlich B, Straus WL. Increase in cardiovascular and cerebrovascular disease prevalence in rheumatoid arthritis. J Rheumatol. 2003;30:36–40
  20. Solomon DH, Karlson EW, Rimm EB, et al. Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation. 2003;107:1303–1307
  21. Fischer LM, Schlienger RG, Matter C, et al. Effect of rheumatoid arthritis or systemic lupus erythematosus on the risk of first-time acute myocardial infarction. Am J Cardiol. 2004;93:198–200
  22. Turesson C, Jarenros A, Jacobsson L. Increased incidence of cardiovascular disease in patients with rheumatoid arthritis: results from a community based study. Ann Rheum Dis. 2004;63:952–955
  23. Sodergren A, Stegmayr B, Lundberg V, et al. Increased incidence of and impaired prognosis after acute myocardial infarction among patients with seropositive rheumatoid arthritis. Ann Rheum Dis. 2007;66:263–266
  24. Aubry MC, Maradit-Kremers H, Reinalda MS, et al. Differences in Atherosclerotic Coronary Heart Disease Between Subjects with and without Rheumatoid Arthritis. J Rheumatol. 2007;
  25. Gabriel SE, Crowson CS, O'Fallon WM. Comorbidity in arthritis. J Rheumatol. 1999;26:2475–2479
  26. Wolfe F, Michaud K. Heart failure in rheumatoid arthritis: rates, predictors, and the effect of anti-tumor necrosis factor therapy. Am J Med. 2004;116:305–311
  27. Nicola PJ, Maradit-Kremers H, Roger VL, et al. The risk of congestive heart failure in rheumatoid arthritis: a population-based study over 46 years. Arthritis Rheum. 2005;52:412–420
  28. Davis JM, Crowson CS, Maradit-Kremers H, et al. Heart failure occurs more frequently with a preserved ejection fraction in subjects with rheumatoid arthritis (RA) compared to non-RA subjects. [abstract] Arthritis Rheum. 2006;54:S388
  29. Davis JM, Crowson CS, Maradit-Kremers H, et al. Mortality following heart failure is higher among rheumatoid arthritis (RA) subjects compared to non-RA subjects. [abstract] Arthritis Rheum. 2006;54:S387–S388
  30. Solomon DH, Curhan GC, Rimm EB, et al. Cardiovascular risk factors in women with and without rheumatoid arthritis. Arthritis Rheum. 2004;50:3444–3449
  31. Maradit-Kremers H, Nicola PJ, Crowson CS, et al. Raised erythrocyte sedimentation rate signals heart failure in patients with rheumatoid arthritis. Ann Rheum Dis. 2007;66:76–80
  32. Jacobsson LT, Turesson C, Hanson RL, et al. Joint swelling as a predictor of death from cardiovascular disease in a population study of Pima Indians. Arthritis Rheum. 2001;44:1170–1176
  33. Wallberg-Jonsson S, Johansson H, Ohman ML, et al. Extent of inflammation predicts cardiovascular disease and overall mortality in seropositive rheumatoid arthritis (A retrospective cohort study from disease onset). J Rheumatol. 1999;26:2562–2571
  34. Moreland LW, O'Dell JR. Glucocorticoids and rheumatoid arthritis: back to the future?. Arthritis Rheum. 2002;46:2553–2563
  35. Davis JM, Maradit Kremers H, Crowson CS, et al. Glucocorticoids and cardiovascular events in rheumatoid arthritis: A population-based cohort study. Arthritis Rheum. 2007;56:820–830
  36. Choi HK, Hernan MA, Seeger JD, et al. Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study. Lancet. 2002;359:1173–1177
  37. Prodanovich S, Kirsner RS, Taylor JR. Treatment of patients hospitalized for psoriasis. Dermatol Clin. 2000;18:425–435viii.
  38. Landewe RB, van den Borne BE, Breedveld FC, et al. Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity. Lancet. 2000;355:1616–1617
  39. Suissa S, Bernatsky S, Hudson M. Antirheumatic drug use and the risk of acute myocardial infarction. Arthritis Rheum. 2006;55:531–536
  40. van Halm VP, Nurmohamed MT, Twisk JW, et al. Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study. Arthritis Res Ther. 2006;8:R151
  41. Basile JN. Optimizing antihypertensive treatment in clinical practice. Am J Hypertens. 2003;16:13S–17S
  42. Pincus T, Gibofsky A, Weinblatt ME. Urgent care and tight control of rheumatoid arthritis as in diabetes and hypertension: better treatments but a shortage of rheumatologists. Arthritis Rheum. 2002;46:851–854

 This work was supported by grants from the National Institutes of Health: R01 AR46849 and AR-30582.

PII: S0002-9343(08)00590-1

doi: 10.1016/j.amjmed.2008.06.011

The American Journal of Medicine
Volume 121, Issue 10, Supplement 1 , Pages S9-S14 , October 2008

Article Tools

* Image Usage & Resolution