The American Journal of Medicine
Volume 121, Issue 9 , Pages 811-819 , September 2008

Sex Differences in Environmental and Genetic Factors for Hypertension

  • Yin Ruixing, MD

      Affiliations

    • Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, P. R. China
    • Corresponding Author InformationRequests for reprints should be addressed to Yin Ruixing, MD, Department of Cardiology, Institute of Cardiovascular Diseases, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, P. R. China
    • ,
  • Wu Jinzhen, MSc

      Affiliations

    • Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, P. R. China
    • ,
  • Pan Shangling, MD

      Affiliations

    • Department of Pathophysiology, School of Premedical Sciences, Guangxi Medical University, Nanning, Guangxi, P. R. China
    • ,
  • Lin Weixiong, MSc

      Affiliations

    • Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, P. R. China
    • ,
  • Yang Dezhai, MSc

      Affiliations

    • Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, P. R. China
    • ,
  • Chen Yuming, MSc

      Affiliations

    • Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, P. R. China

References 

  1. Wolf-Maier K, Cooper RS, Banegas JR, et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA. 2003;289:2363–2369
  2. Ruixing Y, Yuming C, Shangling P, et al. Effects of demographic, dietary and other lifestyle factors on the prevalence of hyperlipidemia in Guangxi Hei Yi Zhuang and Han populations. Eur J Cardiovasc Prev Rehabil. 2006;13:977–984
  3. Ruixing Y, Limei Y, Yuming C, et al. Prevalence, awareness, treatment, control and risk factors of hypertension in the Guangxi Hei Yi Zhuang and Han populations. Hypertens Res. 2006;29:423–432
  4. People's Republic of China—United States Cardiovascular and Cardiopulmonary Epidemiology Research Group. An epidemiological study of cardiovascular and cardiopulmonary disease risk factors in four populations in the People's Republic of China (Baseline report from the P.R.C.-U.S.A. Collaborative Study). Circulation. 1992;85:1083–1096
  5. Lyu LC, Yeh CY, Lichtenstein AH, et al. Association of sex, adiposity, and diet with HDL subclasses in middle-aged Chinese. Am J Clin Nutr. 2001;74:64–71
  6. Yang YX, Wang GY, Pan XC. The 2002 Chinese Food Composition Table. In: Beijing: Medical Publishing House of Beijing University; 2002;p. 1–258
  7. Paffenbarger RS, Wing AL, Hyde RT. Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol. 1978;108:161–175
  8. Ruixing Y, Rongshan L, Weixiong L, et al. Effect of the MTP-493 G/T polymorphism on the lipid profiles of the Guangxi Hei Yi Zhuang and Han populations. Eur J Lipid Sci Technol. 2006;108:561–568
  9. Lynch AI, Arnett DK, Davis BR, et al. Sex-specific effects of AGT-6 and ACE I/D on pulse pressure after 6 months on antihypertensive treatment: the GenHAT study. Ann Hum Genet. 2007;71(Pt 6):735–745
  10. Minami J, Todoroki M, Ishimitsu T, et al. Effects of alcohol intake on ambulatory blood pressure, heart rate, and heart rate variability in Japanese men with different ALDH2 genotypes. J Hum Hypertens. 2002;16:345–351
  11. Malczewska-Malec M, Wybranska I, Leszczynska-Golabek I, et al. An analysis of the link between polymorphisms of the beta 2 and beta 3 adrenergic receptor gene and metabolic parameters among Polish Caucasians with familial obesity. Med Sci Monit. 2003;9:CR225–CR234
  12. Nakayama J, Yoshizawa T, Yamamoto N, Arinami T. Mutation analysis of the calpastatin gene (CAST) in patients with Alzheimer's disease. Neurosci Lett. 2002;320:77–80
  13. Lanfear DE, Jones PG, Marsh S, et al. Connexin37 (GJA4) genotype predicts survival after an acute coronary syndrome. Am Heart J. 2007;154:561–566
  14. Bauerfeind A, Knoblauch H, Costanza MC, et al. Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations. Hum Hered. 2006;61:123–131
  15. Li B, Ge D, Wang Y, et al. Lipoprotein lipase gene polymorphisms and blood pressure levels in the Northern Chinese Han population. Hypertens Res. 2004;27:373–378
  16. Meirhaeghe A, Boreham CA, Murray LJ, et al. A possible role for the PPARG Pro12Ala polymorphism in preterm birth. Diabetes. 2007;56:494–498
  17. Garcia SI, Porto PI, Dieuzeide G, et al. Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension. Hypertension. 2001;38:683–687
  18. Kokubo Y, Tomoike H, Tanaka C, et al. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. Hypertens Res. 2006;29:611–619
  19. Cooperative Meta-analysis Group of China Obesity Task Force. Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population. Zhonghua Xin Xue Guan Bing Za Zhi. 2002;23:5–10
  20. O'Meara JG, Kardia SL, Armon JJ, et al. Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study. Arch Intern Med. 2004;164:1313–1318
  21. Wang X, Poole JC, Treiber FA, et al. Ethnic and gender differences in ambulatory blood pressure trajectories: results from a 15-year longitudinal study in youth and young adults. Circulation. 2006;114:2780–2787
  22. Pickering TG. Mental stress as a causal factor in the development of hypertension and cardiovascular disease. Curr Hypertens Rep. 2001;3:249–254
  23. Steptoe A, Cropley M. Persistent high job demands and reactivity to mental stress predict future ambulatory blood pressure. J Hypertens. 2000;18:581–586
  24. Marmot MG, Elliott P, Shipley MJ, et al. Alcohol and blood pressure: the INTERSALT study. BMJ. 1994;308:1263–1267
  25. Grassi GM, Somers VK, Renk WS, et al. Effects of alcohol intake on blood pressure and sympathetic nerve activity in normotensive humans: a preliminary report. J Hypertens Suppl. 1989;7:S20–S21
  26. Kojima S, Kawano Y, Abe H, et al. Acute effects of alcohol ingestion on blood pressure and erythrocyte sodium concentration. J Hypertens. 1993;11:185–190
  27. Arquizan C, Touze E, Moulin T, et al. Blood pressure, smoking and oral contraceptive control after cryptogenic stroke in young adults in the PFO-ASA Study. Cerebrovasc Dis. 2005;20:41–45
  28. Sorensen K, Kristensen KS, Bang LE, et al. Increased systolic ambulatory blood pressure and microalbuminuria in treated and non-treated hypertensive smokers. Blood Press. 2004;13:362–368
  29. Droyvold WB, Midthjell K, Nilsen TI, Holmen J. Change in body mass index and its impact on blood pressure: a prospective population study. Int J Obes Relat Metab Disord. 2005;29:650–655
  30. Hu FB, Wang B, Chen C, et al. The metabolic body mass index and cardiovascular risk factors in a rural Chinese population. Am J Epidemiol. 2000;51:88–97
  31. Castelli WP, Anderson K. A population at risk (Prevalence of high cholesterol levels in hypertensive patients in the Framingham Study). Am J Med. 1986;80:23–32
  32. Anderson KM, Castelli WP, Levy D. Cholesterol and mortality (30 years of follow-up from the Framingham study). JAMA. 1987;257:2176–2180
  33. Haffner SM, Miettinen H, Gaskill SP, Stern MP. Metabolic precursors of hypertension: the San Antonio Heart Study. Arch Intern Med. 1996;156:1994–2000
  34. Halperin RO, Sesso HD, Ma J, et al. Dyslipidemia and the risk of incident hypertension in men. Hypertension. 2006;47:45–50
  35. Shen BJ, Todaro JF, Niaura R, et al. Are metabolic risk factors one unified syndrome? (Modeling the structure of the metabolic syndrome X). Am J Epidemiol. 2003;157:701–711
  36. Leyva F, Godsland IF, Worthington M, et al. Factors of the metabolic syndrome: baseline interrelationships in the first follow-up cohort of the HDDRISC Study (HDDRISC-1) (Heart Disease and Diabetes Risk Indicators in a Screened Cohort). Arterioscler Thromb Vasc Biol. 1998;18:208–214
  37. Nickenig G, Harrison DG. The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: Part II: AT(1) receptor regulation. Circulation. 2002;105:530–536
  38. Nickenig G, Harrison DG. The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: Part I: oxidative stress and atherogenesis. Circulation. 2002;105:393–396
  39. Kamide K, Kokubo Y, Yang J, et al. Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population. J Hypertens. 2005;23:955–960
  40. Yang W, Huang J, Ge D, et al. Lipoprotein lipase gene is in linkage with blood pressure phenotypes in Chinese pedigrees. Hum Genet. 2004;115:8–12
  41. Bhavani AB, Sastry KB, Reddy NK, Padma T. Lipid profile and apolipoprotein E polymorphism in essential hypertension. Indian Heart J. 2005;57:151–157
  42. Izawa H, Yamada Y, Okada T, et al. Prediction of genetic risk for hypertension. J Cardiol. 2004;43:92–93
  43. Gu D, Reynolds K, Wu X, et al. Prevalence, awareness, treatment, and control of hypertension in China. Hypertension. 2002;40:920–927
  44. Dasgupta K, O'Loughlin J, Chen S, et al. Emergence of sex differences in prevalence of high systolic blood pressure: analysis of a longitudinal adolescent cohort. Circulation. 2006;114:2663–2670
  45. Khalil RA. Sex hormones as potential modulators of vascular function in hypertension. Hypertension. 2005;46:249–254

 This study was supported by the National Natural Science Foundation of China (No. 30360038).

PII: S0002-9343(08)00474-9

doi: 10.1016/j.amjmed.2008.04.026

The American Journal of Medicine
Volume 121, Issue 9 , Pages 811-819 , September 2008

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