The American Journal of Medicine
Volume 121, Issue 9 , Pages 748-757 , September 2008

Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options

  • Ashish Aneja, MD

      Affiliations

    • The Mount Sinai Cardiovascular Institute, New York, NY
    • ,
  • W.H. Wilson Tang, MD

      Affiliations

    • Section of Heart Failure, Department of Cardiology, Cleveland Clinic, Ohio
    • ,
  • Sameer Bansilal, MD

      Affiliations

    • The Mount Sinai Cardiovascular Institute, New York, NY
    • ,
  • Mario J. Garcia, MD

      Affiliations

    • The Mount Sinai Cardiovascular Institute, New York, NY
    • ,
  • Michael E. Farkouh, MD, MSc

      Affiliations

    • The Mount Sinai Cardiovascular Institute, New York, NY
    • Corresponding Author InformationRequests for reprints should be addressed to Michael E. Farkouh, MD, MSc, 1 Gustave Levy Place, Box 1074, Mount Sinai Cardiovascular Institute, New York, NY 10029

  • Image Result

    Overall schema for the pathogenesis of diabetic cardiomyopathy. FFA=free fatty acid; CPC=cardiac progenitor cells; RAAS=renin-angiotensin-aldosterone system.

    Overall schema for the pathogenesis of diabetic cardiomyopathy. FFA=free fatty acid; CPC=cardiac progenitor cells; RAAS=renin-angiotensin-aldosterone system.

  • Image Result

    The role of altered myocardial metabolism in the development of diabetic cardiomyopathy. FFA=free fatty acid; PDH=pyruvate dehydrogenase.

    The role of altered myocardial metabolism in the development of diabetic cardiomyopathy. FFA=free fatty acid; PDH=pyruvate dehydrogenase.

  • Image Result

    Effects of hyperglycemia on the diabetic myocardium. RAAS=renin-angiotensin-aldosterone system.

    Effects of hyperglycemia on the diabetic myocardium. RAAS=renin-angiotensin-aldosterone system.

  • Image Result

    Echocardiographic image of a patient with diabetic cardiomyopathy with ventricular hypertrophy.

    Echocardiographic image of a patient with diabetic cardiomyopathy with ventricular hypertrophy.

PII: S0002-9343(08)00471-3

doi: 10.1016/j.amjmed.2008.03.046

The American Journal of Medicine
Volume 121, Issue 9 , Pages 748-757 , September 2008

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