The American Journal of Medicine
Volume 121, Issue 9 , Pages 805-810 , September 2008

Excess Heparin Dosing Among Fibrinolytic-treated Patients with ST-Segment Elevation Myocardial Infarction

  • Tracy Y. Wang, MD, MS

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    • Corresponding Author InformationRequests for reprints should be addressed to Tracy Y. Wang, MD, MS, Duke Clinical Research Institute, 2400 Pratt Street, Room 0311, Terrace Level, Durham, NC 27705
    • ,
  • Anita Y. Chen, MS

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    • ,
  • Karen P. Alexander, MD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    • ,
  • E. Magnus Ohman, MD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    • ,
  • W. Brian Gibler, MD

      Affiliations

    • University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Eric D. Peterson, MD, MPH

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    • ,
  • Matthew T. Roe, MD, MHS

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina

  • Image Result

    Dosing patterns of bolus (A) and infusion (B) unfractionated heparin.

    Dosing patterns of bolus (A) and infusion (B) unfractionated heparin.

  • Image Result

    Unadjusted bleeding and transfusion outcomes stratified by severity of excess dosing.

    Unadjusted bleeding and transfusion outcomes stratified by severity of excess dosing.

  • Image Result

    Adjusted odds ratio of major bleeding and transfusion for patients with STEMI receiving mild and major excess unfractionated heparin dosing referenced to no excess heparin dosing. Odds ratios adjusted

    Adjusted odds ratio of major bleeding and transfusion for patients with STEMI receiving mild and major excess unfractionated heparin dosing referenced to no excess heparin dosing. Odds ratios adjusted for age, sex, body mass index, renal insufficiency, and signs of heart failure. OR=odds ratio; CI=confidence interval.

 CRUSADE was funded by Schering-Plough Corporation. Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership and PDL Pharmaceuticals provided additional funding support. Millennium Pharmaceuticals Inc, also partly funded this work.

PII: S0002-9343(08)00445-2

doi: 10.1016/j.amjmed.2008.04.023

The American Journal of Medicine
Volume 121, Issue 9 , Pages 805-810 , September 2008

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