The American Journal of Medicine
Volume 121, Issue 8 , Pages 726-732 , August 2008

Anemia and Heart Failure: A Community Study

  • Shannon M. Dunlay, MD

      Affiliations

    • Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minn
    • ,
  • Susan A. Weston, MS

      Affiliations

    • Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minn.
    • ,
  • Margaret M. Redfield, MD

      Affiliations

    • Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minn
    • ,
  • Jill M. Killian, BS

      Affiliations

    • Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minn.
    • ,
  • Véronique L. Roger, MD, MPH

      Affiliations

    • Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minn
    • Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minn.
    • Corresponding Author InformationRequests for reprints should be addressed to Véronique L. Roger, MD, MPH, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

  • Image Result

    Time trends in the prevalence of anemia. Trends in the prevalence of anemia by year of heart failure diagnosis were examined from 1979 to 2002.

    Time trends in the prevalence of anemia. Trends in the prevalence of anemia by year of heart failure diagnosis were examined from 1979 to 2002.

  • Image Result

    Mortality by presence of anemia and hemoglobin level. Mortality during follow-up was analyzed by anemia status in the retrospective (A) and prospective (B) cohorts. Two-year mortality estimates by hem

    Mortality by presence of anemia and hemoglobin level. Mortality during follow-up was analyzed by anemia status in the retrospective (A) and prospective (B) cohorts. Two-year mortality estimates by hemoglobin level are shown in the retrospective (C) and prospective (D) cohorts. *Kaplan-Meier curves were truncated at 3 years follow-up in both cohorts to allow direct comparison.

  • Image Result
    Adjusted HRs for mortality in patients with heart failure are shown by hemoglobin level. HRs for death are shown by hemoglobin level in the retrospective and prospective cohorts. The results are furth

    Adjusted HRs for mortality in patients with heart failure are shown by hemoglobin level. HRs for death are shown by hemoglobin level in the retrospective and prospective cohorts. The results are further adjusted for heart failure severity in the prospective cohort. Model A adjusted for age, sex, coronary artery disease, diabetes mellitus, tobacco use, previous malignancy, BMI, and creatinine clearance. Model B adjusted for above plus NYHA functional class, ejection fraction, and BNP.

 This study was supported by grants from the National Institute of Health (RO1 HL 59205, RO1 HL 72435) and by an American Heart Association Postdoctoral Greater Midwest Fellowship Award to Dr Dunlay. Dr Roger is an Established Investigator of the American Heart Association.

PII: S0002-9343(08)00432-4

doi: 10.1016/j.amjmed.2008.03.039

The American Journal of Medicine
Volume 121, Issue 8 , Pages 726-732 , August 2008

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