The American Journal of Medicine
Volume 121, Issue 8 , Pages 709-714 , August 2008

Clinical Significance and Predictors of Community-Onset Pseudomonas aeruginosa Bacteremia

  • Hae Suk Cheong, MD

      Affiliations

    • Division of Infectious Disease, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • ,
  • Cheol-In Kang, MD

      Affiliations

    • Division of Infectious Disease, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • ,
  • Yu Mi Wi, MD

      Affiliations

    • Division of Infectious Disease, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • ,
  • Eun Seok Kim, MD

      Affiliations

    • Division of Infectious Disease, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • ,
  • Jin Seo Lee, MD

      Affiliations

    • Division of Infectious Disease, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • ,
  • Kwan Soo Ko, PhD

      Affiliations

    • Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, Republic of Korea
    • ,
  • Doo Ryeon Chung, MD

      Affiliations

    • Division of Infectious Disease, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • ,
  • Nam Yong Lee, MD

      Affiliations

    • Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    • ,
  • Jae-Hoon Song, MD

      Affiliations

    • Division of Infectious Disease, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, Republic of Korea
    • ,
  • Kyong Ran Peck, MD, PhD

      Affiliations

    • Division of Infectious Disease, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • Corresponding Author InformationRequests for reprints should be addressed to Kyong Ran Peck, MD, PhD, Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 ILwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea.

References 

  1. Chatzinikolaou I, Abi-Said D, Bodey GP, et al. Recent experience with Pseudomonas aeruginosa bacteremia in patients with cancer: Retrospective analysis of 245 episodes. Arch Intern Med. 2000;160(4):501–509
  2. Lodise TP, Patel N, Kwa A, et al. Predictors of 30-day mortality among patients with Pseudomonas aeruginosa bloodstream infections: the impact of delayed appropriate antibiotic selection. Antimicrob Agents Chemother. 2007;51(10):3510–3515
  3. Kang CI, Kim SH, Kim HB, et al. Pseudomonas aeruginosa bacteremia: risk factors for mortality and influence of delayed receipt of effective antimicrobial therapy on clinical outcome. Clin Infect Dis. 2003;37(6):745–751
  4. Vidal F, Mensa J, Almela M, et al. Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment (Analysis of 189 episodes). Arch Intern Med. 1996;156(18):2121–2126
  5. Zelenitsky SA, Harding GK, Sun S, et al. Treatment and outcome of Pseudomonas aeruginosa bacteraemia: an antibiotic pharmacodynamic analysis. J Antimicrob Chemother. 2003;52(4):668–674
  6. McDonald JR, Friedman ND, Stout JE, et al. Risk factors for ineffective therapy in patients with bloodstream infection. Arch Intern Med. 2005;165(3):308–313
  7. Friedman ND, Kaye KS, Stout JE, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med. 2002;137(10):791–797
  8. Micek ST, Lloyd AE, Ritchie DJ, et al. Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother. 2005;49(4):1306–1311
  9. Kang CI, Kim SH, Park WB, et al. Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother. 2005;49(2):760–766
  10. Chow JW, Yu VL. Combination antibiotic therapy versus monotherapy for gram-negative bacteraemia: a commentary. Int J Antimicrob Agents. 1999;11(1):7–12
  11. Lesens O, Methlin C, Hansmann Y, et al. Role of comorbidity in mortality related to Staphylococcus aureus bacteremia: a prospective study using the Charlson weighted index of comorbidity. Infect Control Hosp Epidemiol. 2003;24(12):890–896
  12. Spanik S, Krupova I, Trupl J, et al. Bacteremia due to multiresistant gram-negative bacilli in neutropenic cancer patients: a case-controlled study. J Infect Chemother. 1999;5(3):180–184
  13. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing, 15th informational supplement (CLSI/NCCLS document M100-S15). Wayne, PA: CLSI; 2005;
  14. Todeschini G, Franchini M, Tecchio C, et al. Improved prognosis of Pseudomonas aeruginosa bacteremia in 127 consecutive neutropenic patients with hematologic malignancies. Int J Infect Dis. 1998;3(2):99–104
  15. Giamarellou H. Prescribing guidelines for severe Pseudomonas infections. J Antimicrob Chemother. 2002;49(2):229–233
  16. Valles J, Rello J, Ochagavia A, et al. Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. Chest. 2003;123(5):1615–1624
  17. Osmon S, Ward S, Fraser VJ, et al. Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa. Chest. 2004;125(2):607–616

 HS Cheong and CI Kang contributed equally to the study.

PII: S0002-9343(08)00357-4

doi: 10.1016/j.amjmed.2008.03.034

The American Journal of Medicine
Volume 121, Issue 8 , Pages 709-714 , August 2008

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