The American Journal of Medicine
Volume 121, Issue 7 , Pages 632-636 , July 2008

A Spontaneous Prothrombotic Disorder Resembling Heparin-induced Thrombocytopenia

  • Theodore E. Warkentin, MD

      Affiliations

    • Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    • Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    • Corresponding Author InformationRequests for reprints should be addressed to Ted Warkentin, MD, Room 1-180A, Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences (Hamilton General Site), 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada.
    • ,
  • Michael Makris, MD

      Affiliations

    • Department of Haematology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    • ,
  • Richard M. Jay, MD

      Affiliations

    • Division of Medical Oncology and Clinical Haematology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
    • ,
  • John G. Kelton, MD

      Affiliations

    • Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

References 

  1. Warkentin TE, Kelton JG. Delayed-onset heparin-induced thrombocytopenia and thrombosis. Ann Intern Med. 2001;135:502–506
  2. Rice L, Attisha WK, Drexler A, Francis JL. Delayed-onset heparin-induced thrombocytopenia. Ann Intern Med. 2002;136:210–215
  3. Horsewood P, Warkentin TE, Hayward CPM, Kelton JG. The epitope specificity of heparin-induced thrombocytopenia. Br J Haematol. 1996;95:161–167
  4. Kelton JG, Sheridan D, Santos A, et al. Heparin-induced thrombocytopenia: laboratory studies. Blood. 1988;72:925–930
  5. Warkentin TE, Kelton JG. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med. 2001;344:1286–1292
  6. Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med. 1995;332:1330–1335
  7. Rauova L, Zhai L, Kowalska MA, et al. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood. 2006;107:2346–2353
  8. Sheridan D, Carter C, Kelton JG. A diagnostic test for heparin-induced thrombocytopenia. Blood. 1986;67:27–30
  9. Visentin GP, Moghaddam M, Beery SE, et al. Heparin is not required for detection of antibodies associated with heparin-induced thrombocytopenia/thrombosis. J Lab Clin Med. 2001;138:22–31
  10. Mims MP, Manian P, Rice R. Acute cardiorespiratory collapse from heparin: a consequence of heparin-induced thrombocytopenia. Eur J Haematol. 2004;72:366–369
  11. Srinivasan AF, Rice L, Bartholomew JR, et al. Warfarin-induced skin necrosis and venous limb gangrene in the setting of heparin-induced thrombocytopenia. Arch Intern Med. 2004;164:66–70
  12. Warkentin TE, Sheppard JI, Sigouin CS, et al. Gender imbalance and risk factor interactions in heparin-induced thrombocytopenia. Blood. 2006;108:2937–2941
  13. Martinuzzo ME, Forastiero RR, Adamczuk Y, et al. Antiplatelet factor 4-heparin antibodies in patients with antiphospholipid antibodies. Thromb Res. 1999;95:271–279

 Grant support by the Heart and Stroke Foundation of Ontario (T-5207, T-6157 to Dr Warkentin and T-5542 to Dr Kelton).

PII: S0002-9343(08)00261-1

doi: 10.1016/j.amjmed.2008.03.012

The American Journal of Medicine
Volume 121, Issue 7 , Pages 632-636 , July 2008

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