The American Journal of Medicine
Volume 121, Issue 5 , Pages 399-405 , May 2008

New Definition of Myocardial Infarction: Impact on Long-term Mortality

  • Willibald Hochholzer, MD

      Affiliations

    • Herz-Zentrum, Bad Krozingen, Germany
    • Both authors have contributed equally and should therefore be considered first author.
  • ,
  • Heinz J. Buettner, MD

      Affiliations

    • Herz-Zentrum, Bad Krozingen, Germany
    • Both authors have contributed equally and should therefore be considered first author.
  • ,
  • Dietmar Trenk, PhD

      Affiliations

    • Herz-Zentrum, Bad Krozingen, Germany
  • ,
  • Kirsten Laule, BSc

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
  • ,
  • Michael Christ, MD

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
  • ,
  • Franz-Josef Neumann, MD

      Affiliations

    • Herz-Zentrum, Bad Krozingen, Germany
  • ,
  • Christian Mueller, MD

      Affiliations

    • Herz-Zentrum, Bad Krozingen, Germany
    • Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
    • Corresponding Author InformationRequests for reprints should be addressed to Christian Mueller, MD, Department of Medicine, University Hospital Basel, Petersgraben 4, Basel CH-4031, Switzerland.

References 

  1. Wu AH, Apple FS, Gibler WB, et al. National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases. Clin Chem. 1999;45:1104–1121
  2. Apple FS, Quist HE, Doyle PJ, et al. Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations. Clin Chem. 2003;49:1331–1336
  3. Bertrand ME, Simoons ML, Fox KA, et al. Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2002;23:1809–1840
  4. Hamm CW, Goldmann BU, Heeschen C, et al. Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I. N Engl J Med. 1997;337:1648–1653
  5. Mueller C, Neumann FJ, Perruchoud AP, et al. Prognostic value of quantitative troponin T measurements in unstable angina/non-ST-segment elevation acute myocardial infarction treated early and predominantly with percutaneous coronary intervention. Am J Med. 2004;117:897–902
  6. Ohman EM, Armstrong PW, Christenson RH, et al. Cardiac troponin T levels for risk stratification in acute myocardial ischemia (GUSTO IIA Investigators). N Engl J Med. 1996;335:1333–1341
  7. Antman EM, Tanasijevic MJ, Thompson B, et al. Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med. 1996;335:1342–1349
  8. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969
  9. Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction. Circulation. 2007;116:2634–2653
  10. Ferguson JL, Beckett GJ, Stoddart M, et al. Myocardial infarction redefined: the new ACC/ESC definition, based on cardiac troponin, increases the apparent incidence of infarction. Heart. 2002;88:343–347
  11. Trevelyan J, Needham EW, Smith SC, Mattu RK. Impact of the recommendations for the redefinition of myocardial infarction on diagnosis and prognosis in an unselected United Kingdom cohort with suspected cardiac chest pain. Am J Cardiol. 2004;93:817–821
  12. Amit G, Gilutz H, Cafri C, et al. D. What have the new definition of acute myocardial infarction and the introduction of troponin measurement done to the coronary care unit? (Impacts on admission rate, length of stay, case mix and mortality). Cardiology. 2004;102:171–176
  13. Pell JP, Simpson E, Rodger JC, et al. Impact of changing diagnostic criteria on incidence, management, and outcome of acute myocardial infarction: retrospective cohort study. BMJ. 2003;326:134–135
  14. Salomaa V, Koukkunen H, Ketonen M, et al. A new definition for myocardial infarction: what difference does it make. Eur Heart J. 2005;26:1719–1725
  15. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, et al. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project (Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents). Circulation. 1994;90:583–612
  16. Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction—2002: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina). Circulation. 2002;106:1893–1900
  17. Dargie H. Myocardial infarction: redefined or reinvented?. Heart. 2002;88:1–3
  18. Luepker RV, Apple FS, Christenson RH, et al. Case definitions for acute coronary heart disease in epidemiology and clinical research studies. Circulation. 2003;108:2543–2549
  19. Richards AM, Lainchbury JG, Nicholls MG. Unsatisfactory redefinition of myocardial infarction. Lancet. 2001;357:1635–1636
  20. Tunstall-Pedoe H. Redefinition of myocardial infarction by a consensus dissenter. J Am Coll Cardiol. 2001;37:1472–1474
  21. White HD. Things ain't what they used to be: impact of a new definition of myocardial infarction. Am Heart J. 2002;144:933–937
  22. Hallermayer K, Klenner D, Vogel R. Use of recombinant human cardiac Troponin T for standardization of third generation Troponin T methods. Scand J Clin Lab Invest. 1999;230(Suppl):128–131
  23. Horder M, Elser RC, Gerhardt W, et al. International Federation of Clinical Chemistry, Scientific Division Committee on Enzymes: approved recommendation on IFCC methods for the measurement of catalytic concentration of enzymes (Part 7. IFCC method for creatine kinase). Eur J Clin Chem Clin Biochem. 1991;29:435–456
  24. Newby LK, Alpert JS, Ohman EM, et al. Changing the diagnosis of acute myocardial infarction: implications for practice and clinical investigations. Am Heart J. 2002;144:957–980
  25. Newby LK, Roe MT, Chen AY, et al. Frequency and clinical implications of discordant creatine kinase-MB and troponin measurements in acute coronary syndromes. J Am Coll Cardiol. 2006;47:312–318

 The authors declare that there are no conflicts of interest. Dr. Mueller was supported by research grants from the Swiss National Science Foundation, the Swiss Heart Foundation, and the Novartis Foundation. Design and conduct of the study as well as the preparation of the manuscript were not influenced by any of the sponsors.

PII: S0002-9343(08)00108-3

doi: 10.1016/j.amjmed.2008.01.033

The American Journal of Medicine
Volume 121, Issue 5 , Pages 399-405 , May 2008