The American Journal of Medicine
Volume 121, Issue 5 , Pages 385-386 , May 2008

Pseudocyanosis: Drug-Induced Skin Hyperpigmentation Can Mimic Cyanosis

  • Jason Weatherald, BSc

      Affiliations

    • Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Thomas J. Marrie, MD

      Affiliations

    • Faculty of Medicine and Dentistry, Walter C. Mackenzie Health Sciences Center, University of Alberta, Edmonton, Alberta, Canada.
    • Corresponding Author InformationRequests for reprints should be addressed to Thomas J. Marrie, MD, Faculty of Medicine and Dentistry, 2J2.01 Walter C. Mackenzie Health Sciences Center, 8440 112 Street, Edmonton, AB T6G 2R7, Canada.

References 

  1. Stapczynski JS. Respiratory diseases: Cyanosis. In:  Tintinalli JE,  Kelen GD,  Stapczynski JS editor. Emergency Medicine: A Comprehensive Study Guide. 6th edn.. New York, NY: McGraw-Hill, Medical Publishing Division; 2004;p. 443–444
  2. Kasper DL, Braunwald E, Hauser S, et al. Harrison's Principles of Internal Medicine. 16th edn.. New York, NY: McGraw-Hill, Medical Publication Division; 2005;
  3. Bhatara VS, López-Muñoz F, Gupta S. Guest editorial: celebrating the 50th anniversary of the introduction of chlorpromazine in North America and the advent of the psychopharmacology revolution. Ann Clin Psychiatry. 2005;17:109–111
  4. Greiner AC, Berry K. Skin pigmentation and corneal and lens opacities with prolonged chlorpromazine therapy. Can Med Assoc J. 1964;90:663–665
  5. Harris L, McKenna WJ, Rowland E, et al. Side effects of long-term amiodarone therapy. Circulation. 1983;67:45–51
  6. Eisen D, Hakim MD. Minocycline-induced pigmentation (Incidence, prevention and management). Drug Saf. 1998;18:431–440
  7. Levantine A, Almeyda J. Drug induced changes in pigmentation. Br J Dermatol. 1973;89:105–112
  8. Hendrix JD, Greer KE. Cutaneous hyperpigmentation caused by systemic drugs. Int J Dermatol. 1992;31:458–466
  9. Chang AL, Khosravi V, Egbert B. A case of argyria after colloidal silver ingestion. J Cutan Pathol. 2006;33:809–811
  10. Dereure O. Drug-induced skin pigmentation (Epidemiology, diagnosis and treatment). Am J Clin Dermatol. 2001;2:253–262
  11. Smith RW, Leppard B, Barnett NL, et al. Chrysiasis revisited: a clinical and pathological study. Br J Dermatol. 1995;133:671–678

 Thomas J. Marrie, MD, Section Editor

PII: S0002-9343(08)00078-8

doi: 10.1016/j.amjmed.2008.01.029

The American Journal of Medicine
Volume 121, Issue 5 , Pages 385-386 , May 2008

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