The American Journal of Medicine
Volume 121, Issue 5 , Pages 419-425 , May 2008

Efficacy of Oral β-Lactam versus Non-β-Lactam Treatment of Uncomplicated Cellulitis

  • Karl J. Madaras-Kelly, PharmD, MPH

      Affiliations

    • College of Pharmacy, Idaho State University, Boise, Idaho
    • Department of Veterans Affairs Medical Center, Boise, Idaho
    • Corresponding Author InformationRequests for reprints should be addressed to Karl Madaras-Kelly, PharmD, MPH, VA Medical Center, Clinical Pharmacy, 500 W Fort St. (119A), Boise, ID 83702.
    • ,
  • Richard E. Remington, MS

      Affiliations

    • Quantified Inc., Boise, Idaho
    • ,
  • Catherine M. Oliphant, PharmD

      Affiliations

    • College of Pharmacy, Idaho State University, Boise, Idaho
    • Department of Veterans Affairs Medical Center, Boise, Idaho
    • ,
  • Kevin L. Sloan, MD

      Affiliations

    • University of Washington, School of Medicine, Seattle, Wash
    • Veterans Affairs Puget Sound Health Care System, Seattle, Wash
    • ,
  • David T. Bearden, PharmD

      Affiliations

    • Oregon State University, College of Pharmacy, Portland, Ore
    • Department of Veterans Affairs Medical Center, Portland, Ore.

References 

  1. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections. Clin Infect Dis. 2005;41:1373–1406
  2. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355:666–674
  3. Fridkin SK, Hageman JC, Morrison M, et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med. 2005;352(14):1436–1444
  4. Young DM, Harris HW, Charlebois ED, et al. An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients. Arch Surg. 2004;139(9):947–951
  5. Miller LG, Quan C, Shay A, et al. A prospective investigation of outcomes after hospital discharge for endemic, community-acquired Methicillin-resistant and -susceptible Staphylococcus aureus skin infection. Clin Infect Dis. 2007;44(4):483–492
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  8. Madaras-Kelly KJ, Arbogast R, Jue SG. Increased therapeutic failure for cephalexin versus comparator antibiotics in the treatment of uncomplicated outpatient cellulitis. Pharmacotherapy. 2000;20(2):199–205
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  12. Madaras-Kelly K, Michas P, George M, et al. A randomized crossover study investigating the influence of ranitidine or omeprazole on the pharmacokinetics of cephalexin monohydrate. J Clin Pharmacol. 2004;44(12):1391–1397
  13. Miller LG, Perdreau-Remington F, Bayer AS, et al. Clinical and epidemiologic characteristics cannot distinguish community-associated methicillin-resistant Staphylococcus aureus infection from methicillin-susceptible S. aureus infection: a prospective investigation. Clin Infect Dis. 2007;44:471–482
  14. Harbarth S, Nobre V, Pittet D. Does antibiotic selection impact patient outcome?. Clin Infect Dis. 2007;44:87–93
  15. Mitropoulos IF, Rotschafer JC, Rodvold KA. Adverse events associated with the use of oral cephalosporins/cephems. Diagn Microbiol Infect Dis. 2007;57(3 Suppl):67S–76S
  16. Centers for Disease Control and Prevention (CDC). Severe Clostridium difficile-associated disease in populations previously at low risk—four states, 2005. MMWR Morb Mortal Wkly Rep. 2005;54(47):1201–1205
  17. Falagas ME, Matthaiou DK, Vardakas KZ. Fluoroquinolones vs beta-lactams for empirical treatment of immunocompetent patients with skin and soft tissue infections: a meta-analysis of randomized controlled trials. Mayo Clin Proc. 2006;81(12):1553–1566
  18. Loeb M, Main C, Walker-Dilks C, Eady A. Antimicrobial drugs for treating methicillin-resistant Staphylococcus aureus colonization. Cochrane Database Syst Rev. 2003;(4):CD003340

 This work was supported with resources and the use of facilities at the Boise, Portland, and Puget Sound Veterans Affairs Medical Centers (VAMC). The study was funded by a research grant from Abbott Pharmaceuticals. The study sponsors had no role in the data collection, analysis, or reporting of the study results.

PII: S0002-9343(08)00077-6

doi: 10.1016/j.amjmed.2008.01.028

The American Journal of Medicine
Volume 121, Issue 5 , Pages 419-425 , May 2008

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