The American Journal of Medicine
Volume 121, Issue 4 , Pages 316-323 , April 2008

Delay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction

  • Henry H. Ting, MD, MBA

      Affiliations

    • Division of Cardiovascular Diseases and Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minn
    • Corresponding Author InformationRequests for reprints should be addressed to Henry H. Ting, MD, MBA, Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.
    • ,
  • Elizabeth H. Bradley, PhD

      Affiliations

    • Division of Health Policy and Administration, Department of Epidemiology and Public Health, Yale University School of Medicine and Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Conn
    • Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine and Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Conn
    • ,
  • Yongfei Wang, MS

      Affiliations

    • Section of Cardiovascular Medicine, Yale University School of Medicine and Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Conn
    • ,
  • Brahmajee K. Nallamothu, MD, MPH

      Affiliations

    • VA Health Services Research and Development Center for Excellence and Department of Medicine, University of Michigan Medical School, Ann Arbor.
    • ,
  • Bernard J. Gersh, MB, ChB, DPhil

      Affiliations

    • Division of Cardiovascular Diseases and Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minn
    • ,
  • Veronique L. Roger, MD, MPH

      Affiliations

    • Division of Cardiovascular Diseases and Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minn
    • ,
  • Judith H. Lichtman, PhD

      Affiliations

    • Division of Health Policy and Administration, Department of Epidemiology and Public Health, Yale University School of Medicine and Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Conn
    • ,
  • Jeptha P. Curtis, MD

      Affiliations

    • Section of Cardiovascular Medicine, Yale University School of Medicine and Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Conn
    • ,
  • Harlan M. Krumholz, MD, SM

      Affiliations

    • Division of Health Policy and Administration, Department of Epidemiology and Public Health, Yale University School of Medicine and Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Conn
    • Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine and Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Conn
    • Section of Cardiovascular Medicine, Yale University School of Medicine and Yale-New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Conn

References 

  1. Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet. 1994;343:311–322
  2. Newby LK, Rutsch WR, Califf RM, et al. Time from symptom onset to treatment and outcomes after thrombolytic therapy: GUSTO-1 investigators. J Am Coll Cardiol. 1996;27:1646–1655
  3. Goldberg RJ, Mooradd M, Guriwitz JH, et al. Impact of time to treatment with tissue plasminogen activator on morbidity and mortality following acute myocardial infarction (NRMI 2). Am J Cardiol. 1998;82:259–264
  4. Zijlstra F, Patel A, Jones M, et al. Clinical characteristics and outcome of patients with early (<2 h), intermediate (2-4 h) and late (>4 h) presentation treated by primary coronary angioplasty or thrombolytic therapy for acute myocardial infarction. Eur Heart J. 2002;23:550–557
  5. Gibson CM, Murphy SA, Kirtane AJ, et al. Association of duration of symptoms at presentation with angiographic and clinical outcomes after fibrinolytic therapy in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2004;44:980–987
  6. Cannon CP, Gibson CM, Lambrew CT, et al. Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction. JAMA. 2000;283:2941–2947
  7. De Luca G, Suryapranata H, Zijlstra F, et al. Symptom-onset-to-balloon time and mortality in patients with acute myocardial infarction treated by primary angioplasty. J Am Coll Cardiol. 2003;42:991–997
  8. De Luca G, Suryapranata H, Ottervanger JP, Antman EM. Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: every minute of delay counts. Circulation. 2004;109:1223–1225
  9. Brodie BR, Stone GW, Cox DA, et al. Impact of treatment delays on outcomes of primary percutaneous coronary intervention for acute myocardial infarction: analysis from the CADILLAC trial. Am Heart J. 2006;151:1231–1238
  10. Brodie BR, Webb J, Cox DA, et al. Impact of time to treatment on myocardial reperfusion and infarct size with primary percutaneous coronary intervention for acute myocardial infarction (from the EMERALD Trial). Am J Cardiol. 2007;99:1680–1686
  11. McNamara RL, Wang Y, Herrin J, et al. Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2006;47:2180–2186
  12. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction; a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). J Am Coll Cardiol. 2004;44:E1–E211
  13. Bradley EH, Herrin J, Wang Y, et al. Strategies for reducing door-to-balloon time in acute myocardial infarction. N Engl J Med. 2006;355:2308–2320
  14. Jacobs AK, Antman EA, Ellrodt G, et al. Recommendation to develop strategies to increase the number of ST-elevation myocardial infarction patients with timely access to primary percutaneous coronary intervention. Circulation. 2006;113:2152–2163
  15. Rogers WJ, Canto JG, Lambrew CT, et al. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the U.S. from 1990 through 1999: The National Registry of Myocardial Infarction 1, 2, and 3. J Am Coll Cardiol. 2000;36:2056–2063
  16. Every NR, Frederick PD, Robinson M, et al. A comparison of the National Registry of Myocardial Infarction 2 with the Cooperative Cardiovascular Project. J Am Coll Cardiol. 1999;33:1886–1894
  17. Bland JM, Altman DG. The use of transformation when comparing two means. BMJ. 1996;312:1153
  18. Bland JM, Altman DG. Transformations, means, and confidence intervals. BMJ. 1996;312:1079
  19. King G, Tomz M, Wittenberg J. Making the most of statistical analyses: improving interpretation and presentation. Am J Pol Sci. 1998;44:341–355
  20. Nallamothu BK, Bates ER, Herrin J, et al. Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States: National Registry of Myocardial Infarction 3/4 analysis. Circulation. 2005;111:761–767
  21. Magid DK, Wang Y, Herrin J, et al. Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction. JAMA. 2005;294:803–812
  22. Moser DK, Kimble LP, Alberts MJ, et al. Reducing delay in seeking treatment by patients with acute coronary syndrome and stroke. Circulation. 2006;114:168–182
  23. Luepker RV, Raczynski JM, Osganian S, et al. Effect of a community intervention on patient delay and emergency medical service use in acute coronary heart disease. JAMA. 2000;284:60–67
  24. Goldberg RJ, Gurwitz JH, Gore JM. Duration of and temporal trends (1994-1997) in prehospital delay in patients with acute myocardial infarction: the Second National Registry of Myocardial Infarction. Arch Intern Med. 1999;159:2141–2147
  25. Goldberg RJ, Yarzebski J, Lessard D, Gore JM. Decade-long trends and factors associated with time to hospital presentation in patients with acute myocardial infarction: the Worchester Heart Attack Study. Arch Intern Med. 2000;160:3217–3223
  26. McGinn AP, Rosamond WD, Goff DC, et al. Trends in prehospital delay time and use of emergency medical services for acute myocardial infarction: experience in 4 U.S. communities from 1987-2000. Am Heart J. 2005;150:392–400
  27. Luepker RV. Delay in acute myocardial infarction: why don’t they come to the hospital more quickly and what we can do to reduce delay. Am Heart J. 2005;150:368–370

 Supported by grant R01 HL072575 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland.

PII: S0002-9343(07)01190-4

doi: 10.1016/j.amjmed.2007.11.017

The American Journal of Medicine
Volume 121, Issue 4 , Pages 316-323 , April 2008

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