The American Journal of Medicine
Volume 121, Issue 1 , Pages 43-49 , January 2008

Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis

  • Jeffrey S. Berger, MD, MS

      Affiliations

    • Duke Clinical Research Institute, Durham, NC
    • Jeffrey Berger is funded by an American Heart Association Fellow to Faculty Award 0775074N.
    • Corresponding Author InformationRequests for reprints should be addressed to Jeffrey S. Berger, MD, MS, Duke Clinical Research Institute, Duke University Medical Center, Department of Internal Medicine, DUMC 31007, Durham, NC 27710.
    • ,
  • David L. Brown, MD

      Affiliations

    • Stony Brook University School of Medicine, Stony Brook, NY.
    • ,
  • Richard C. Becker, MD

      Affiliations

    • Duke Clinical Research Institute, Durham, NC

  • Image Result

    Flow diagram of the trial selection process.

    Flow diagram of the trial selection process.

  • Image Result

    Effect of aspirin on (A) major cardiovascular events, (B) all-cause mortality, (C) MI, (D) stroke, and (E) major bleeding in patients with stable cardiovascular disease. Sizes of data markers are prop

    Effect of aspirin on (A) major cardiovascular events, (B) all-cause mortality, (C) MI, (D) stroke, and (E) major bleeding in patients with stable cardiovascular disease. Sizes of data markers are proportional to the amount of data contributed by each trial. Test for heterogeneity for major cardiovascular events, P=.571; all-cause mortality, P=.557; MI, P=.650; stroke, P=.974; major bleeding, P=.581. CI=confidence interval; CV=cardiovascular; UK-TIA=United Kingdom Transient Ischemic Attack; SALT=Swedish Aspirin Low-Dose Trial; ESPS-2=European Stroke Prevention Study-2; SAPAT=Swedish Angina Pectoris Aspirin Trial.

  • Image Result
    How does aspirin compare? Number needed to treat with aspirin, statins, and ACE inhibitor to prevent a death, major cardiovascular event, MI, or stroke. CV = cardiovascular; MI = myocardial infarction

    How does aspirin compare? Number needed to treat with aspirin, statins, and ACE inhibitor to prevent a death, major cardiovascular event, MI, or stroke. CV = cardiovascular; MI = myocardial infarction; ACE = angiotensin-converting enzyme.

PII: S0002-9343(07)00985-0

doi: 10.1016/j.amjmed.2007.10.002

The American Journal of Medicine
Volume 121, Issue 1 , Pages 43-49 , January 2008

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