The American Journal of Medicine
Volume 121, Issue 1 , Pages 43-49, January 2008

Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis

  • Jeffrey S. Berger, MD, MS

      Affiliations

    • Duke Clinical Research Institute, Durham, NC
    • Jeffrey Berger is funded by an American Heart Association Fellow to Faculty Award 0775074N.
    • Corresponding Author InformationRequests for reprints should be addressed to Jeffrey S. Berger, MD, MS, Duke Clinical Research Institute, Duke University Medical Center, Department of Internal Medicine, DUMC 31007, Durham, NC 27710.
    • ,
  • David L. Brown, MD

      Affiliations

    • Stony Brook University School of Medicine, Stony Brook, NY.
    • ,
  • Richard C. Becker, MD

      Affiliations

    • Duke Clinical Research Institute, Durham, NC

Abstract 

Objective

Many recommendations for aspirin in stable cardiovascular disease are based on analyses of all antiplatelet therapies at all dosages and in both stable and unstable patients. Our objective was to evaluate the benefit and risk of low-dose aspirin (50-325 mg/d) in patients with stable cardiovascular disease.

Methods

Secondary prevention trials of low-dose aspirin in patients with stable cardiovascular disease were identified by searches of the MEDLINE database from 1966 to 2006. Six randomized trials were identified that enrolled patients with a prior myocardial infarction (MI) (n=1), stable angina (n=1), or stroke/transient ischemic attack (n=4). A random effects model was used to combine results from individual trials.

Results

Six studies randomized 9853 patients. Aspirin therapy was associated with a significant 21% reduction in the risk of cardiovascular events (nonfatal MI, nonfatal stroke, and cardiovascular death) (95% confidence interval [CI], 0.72-0.88), 26% reduction in the risk of nonfatal MI (95% CI, 0.60-0.91), 25% reduction in the risk of stroke (95% CI, 0.65-0.87), and 13% reduction in the risk of all-cause mortality (95% CI, 0.76-0.98). Patients treated with aspirin were significantly more likely to experience severe bleeding (odds ratio 2.2, 95% CI, 1.4-3.4). Treatment of 1000 patients for an average of 33 months would prevent 33 cardiovascular events, 12 nonfatal MIs, 25 nonfatal strokes, and 14 deaths, and cause 9 major bleeding events. Among those with ischemic heart disease, aspirin was most effective at reducing the risk of nonfatal MI and all-cause mortality; however, among those with cerebrovascular disease, aspirin was most effective at reducing the risk of stroke.

Conclusion

In patients with stable cardiovascular disease, low-dose aspirin therapy reduces the incidence of adverse cardiovascular events and all-cause mortality, and increases the risk of severe bleeding.

Keywords: All-cause mortality, Aspirin, Dose, Meta-analysis, Myocardial infarction, Secondary prevention, Stable angina, Stroke

 

PII: S0002-9343(07)00985-0

doi:10.1016/j.amjmed.2007.10.002

The American Journal of Medicine
Volume 121, Issue 1 , Pages 43-49, January 2008

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