The American Journal of Medicine
Volume 120, Issue 11, Supplement 1 , Pages S1-S21, November 2007

Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations

  • Joseph G. Verbalis, MD

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia, USA
    • Corresponding Author InformationRequests for reprints should be addressed to Joseph G. Verbalis, MD, Department of Medicine, 5 PHC, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, District of Columbia 20007.
    • ,
  • Stephen R. Goldsmith, MD

      Affiliations

    • Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    • ,
  • Arthur Greenberg, MD

      Affiliations

    • Division of Nephrology, Department of Medicine, Duke University, Durham, North Carolina, USA
    • ,
  • Robert W. Schrier, MD

      Affiliations

    • Department of Medicine, University of Colorado, Denver, Colorado, USA
    • ,
  • Richard H. Sterns, MD

      Affiliations

    • Department of Medicine, University of Rochester, Rochester, New York, USA

Abstract 

Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease. In addition, overly rapid correction of chronic hyponatremia can cause severe neurologic deficits and death, and optimal treatment strategies for such cases are not established. An expert panel assessed the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin receptor (AVPR) antagonists to hyponatremia therapies. This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists.

Keywords: Antidiuretic hormone, Aquaretics, Hypo-osmolality, Natriuresis, Syndrome of inappropriate antidiuretic hormone secretion, Vasopressin

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 Statement of author disclosure: Please see the Author Disclosure section at the end of this article.

PII: S0002-9343(07)00845-5

doi:10.1016/j.amjmed.2007.09.001

The American Journal of Medicine
Volume 120, Issue 11, Supplement 1 , Pages S1-S21, November 2007

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