The American Journal of Medicine
Volume 121, Issue 1 , Pages 50-57 , January 2008

Biomarkers to Predict Recurrent Cardiovascular Disease: The Heart and Soul Study

  • Michael G. Shlipak, MD, MPH

      Affiliations

    • Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif
    • Department of Medicine, University of California San Francisco, San Francisco, Calif
    • Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif
    • Dr. Shlipak was funded by R01 DK066488.
    • Corresponding Author InformationRequests for reprints should be addressed to Michael G. Shlipak, MD, MPH, 4150 Clement Street (111A1), San Francisco, CA 94121.
    • ,
  • Joachim H. Ix, MD

      Affiliations

    • Division of Nephrology, University of California San Diego, Calif
    • ,
  • Kirsten Bibbins-Domingo, PhD, MD

      Affiliations

    • Division of General Internal Medicine, San Francisco General Hospital, San Francisco, Calif.
    • ,
  • Feng Lin, MS

      Affiliations

    • Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif
    • ,
  • Mary A. Whooley, MD

      Affiliations

    • Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif
    • Department of Medicine, University of California San Francisco, San Francisco, Calif
    • Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif

  • Image Result

    Cardiovascular event incidence rates per 1000 person-years across quartiles of Nt-proBNP, cystatin C, albuminuria, CRP, IL-6, and fibrinogen. Nt-proBNP=N-terminal prohormone brain natriuretic peptide;

    Cardiovascular event incidence rates per 1000 person-years across quartiles of Nt-proBNP, cystatin C, albuminuria, CRP, IL-6, and fibrinogen. Nt-proBNP=N-terminal prohormone brain natriuretic peptide; CRP=C-reactive protein; IL=interleukin.

  • Image Result
    Receiver operator characteristic curves for the standard clinical model (dashed line) and the standard clinical model plus Nt-proBNP, albuminuria, and CRP (solid line). Nt-proBNP=N-terminal prohormone

    Receiver operator characteristic curves for the standard clinical model (dashed line) and the standard clinical model plus Nt-proBNP, albuminuria, and CRP (solid line). Nt-proBNP=N-terminal prohormone brain natriuretic peptide; ACR = albuminuria; CRP=C-reactive protein; AUC=area under the curve.

 The Heart and Soul Study was supported by grants from the Department of Veterans Affairs, the Robert Wood Johnson Foundation, the American Federation for Aging Research, the Ischemia Research and Education Foundation, and the Nancy Kirwan Heart Research Fund. Dade Behring, Inc, paid for the cystatin C measurements. Roche Diagnostics paid for the Nt-proBNP assays.

PII: S0002-9343(07)00844-3

doi: 10.1016/j.amjmed.2007.06.030

The American Journal of Medicine
Volume 121, Issue 1 , Pages 50-57 , January 2008

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