The American Journal of Medicine
Volume 120, Issue 8 , Pages 720-727 , August 2007

Hemoglobin A1c Predicts Diabetes but Not Cardiovascular Disease in Nondiabetic Women

  • Aruna D. Pradhan, MD

      Affiliations

    • Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass
    • Donald W. Reynolds Center for Cardiovascular Research, Boston, Mass
    • Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass
    • Corresponding Author InformationCorrespondence should be addressed to Aruna D. Pradhan, MD, MPH, Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215-1204.
    • ,
  • Nader Rifai, PhD

      Affiliations

    • Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass
    • Department of Pathology, Children’s Hospital Medical Center and Harvard Medical School, Boston, Mass
    • ,
  • Julie E. Buring, ScD

      Affiliations

    • Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass
    • Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Mass
    • ,
  • Paul M. Ridker, MD

      Affiliations

    • Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass
    • Donald W. Reynolds Center for Cardiovascular Research, Boston, Mass
    • Leducq Center for Molecular and Genetic Epidemiology of Cardiovascular Disorders, Boston, Mass
    • Division of Cardiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass

  • Image Result

    Histograms of HbA1c distribution according to 4 main groups: individuals remaining disease-free (N = 24,725), developing incident cardiovascular disease only (N = 600), developing incident diabetes me

    Histograms of HbA1c distribution according to 4 main groups: individuals remaining disease-free (N = 24,725), developing incident cardiovascular disease only (N = 600), developing incident diabetes mellitus only (N = 1154), or developing both cardiovascular disease and diabetes mellitus (N = 84). SD = standard deviation; IQR = interquartile range; CVD = cardiovascular disease; DM = diabetes mellitus; HbA1c = hemoglobin A1c.

  • Image Result
    Kaplan-Meier curves for 10-year diabetes incidence according to baseline HbA1c category. DM = diabetes mellitus; HbA1c = hemoglobin A1c.

    Kaplan-Meier curves for 10-year diabetes incidence according to baseline HbA1c category. DM = diabetes mellitus; HbA1c = hemoglobin A1c.

 Supported by grants from the National Heart, Lung, and Blood Institute (HL58755 and HL43851) and the National Cancer Institute (CA47988) and the Donald W. Reynolds Foundation. Blood specimen analysis supported by funds from Aventis, Inc.

PII: S0002-9343(07)00452-4

doi: 10.1016/j.amjmed.2007.03.022

The American Journal of Medicine
Volume 120, Issue 8 , Pages 720-727 , August 2007

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