The American Journal of Medicine
Volume 120, Issue 4, Supplement 1 , Pages S26-S31 , April 2007

Heterogeneity of Treatment Effects in Schizophrenia

  • T. Scott Stroup, MD, MPH

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to T. Scott Stroup, MD, MPH, Department of Psychiatry, University of North Carolina at Chapel Hill, 10301 Neuroscience Hospital, CB#7160, Chapel Hill, North Carolina 27599-7160.

References 

  1. March JS, Silva SG, Compton S, Shapiro M, Califf R, Krishnan R. The case for practical clinical trials in psychiatry. Am J Psychiatry. 2005;162:836–846
  2. Tunis SR, Stryer DB, Clancy CM. Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA. 2003;290:1624–1632
  3. Fleischhacker WW, Widschwendter CG. Treatment of schizophrenia patients: comparing new-generation antipsychotics to each other. Curr Opin Psychiatry. 2006;19:128–134
  4. Pandiani JA, Banks SM. Interpreting the results of the CATIE study. Psychiatr Serv. 2006;57:140–141
  5. Luchins DJ. Interpreting the results of the CATIE study. Psychiatr Serv. 2006;57:139–140
  6. Stroup TS, McEvoy JP, Swartz MS, et al. The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development. Schizophr Bull. 2003;29:15–31
  7. Lieberman JA, Stroup TS, McEvoy JP, et al. Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005;353:1209–1223
  8. Haddad P, Dursun SM. Selecting antipsychotics in schizophrenia: lessons from CATIE. J Psychopharmacol. 2006;20:332–334
  9. Stroup TS, Lieberman JA, McEvoy JP, et al. CATIE Investigators Effectiveness of olanzapine, quetiapine, risperidone, and ziprasidone in patients with chronic schizophrenia following discontinuation of a previous atypical antipsychotic. Am J Psychiatry. 2006;163:611–622
  10. McEvoy JP, Lieberman JA, Stroup TS, et al. CATIE Investigators Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry. 2006;163:600–610
  11. National Institute of Mental Health. Director’s update: NIMH perspective on antipsychotic reimbursement: using results from CATIE [National Institute of Mental Health Website]. 2005;October 28. Available at: http://www.nimh.nih.gov/about/dirupdate_catie.cfm. Accessed March 1, 2007.

PII: S0002-9343(07)00138-6

doi: 10.1016/j.amjmed.2007.02.005

The American Journal of Medicine
Volume 120, Issue 4, Supplement 1 , Pages S26-S31 , April 2007

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