The American Journal of Medicine
Volume 120, Issue 3, Supplement 1 , Pages S19-S25 , March 2007

Role of the Endocannabinoid System in Regulating Cardiovascular and Metabolic Risk Factors

  • Stephen C. Woods, PhD

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Stephen C. Woods, PhD, Obesity Research Center, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, Ohio 45267.

References 

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  7. Yin HH, Lovinger DM. Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. Proc Natl Acad Sci U S A. 2006;103:8251–8256
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  9. Bensaid M, Gary-Bobo M, Esclangon A, et al. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol. 2003;63:908–914
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  12. Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrie P. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes (Lond). 2004;28:640–648
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  15. Osei-Hyiaman D, DePetrillo M, Pacher P, et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest. 2005;115:1298–1305
  16. Cota D, Marsicano G, Tschop M, et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest. 2003;112:423–431
  17. Sipe JC, Waalen J, Gerber A, Beutler E. Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). Int J Obes (Lond). 2005;29:755–759

 This research was supported by National Institutes of Health (Grant no. DK17844).

PII: S0002-9343(07)00034-4

doi: 10.1016/j.amjmed.2007.01.004

The American Journal of Medicine
Volume 120, Issue 3, Supplement 1 , Pages S19-S25 , March 2007

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