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The American Journal of Medicine
Volume 120, Issue 2,
Supplement 1
, Pages S3-S8
, February 2007
Abdominal Obesity: Role in the Pathophysiology of Metabolic Disease and Cardiovascular Risk
References
- . Global and societal implications of the diabetes epidemic. Nature. 2001;414:782–787
- . Regional adiposity and morbidity. Physiol Rev. 1994;74:761–811
- . Obesity, insulin resistance and cancer risk. Yonsei Med J. 2005;46:449–455
- . Insulin resistance is central to the burden of diabetes. Diabetes Metab Rev. 1997;13:81–86
- . Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005;111:1448–1454
- . Diet and syndrome X. Curr Atheroscler Rep. 2000;2:503–507
- . Visceral obesity, insulin resistance, and dyslipidemia: contribution of endurance exercise training to the treatment of the plurimetabolic syndrome. Exerc Sport Sci Rev. 1997;25:271–300
- . The key role of insulin resistance in the cardiometabolic syndrome. Am J Med Sci. 2005;330:290–294
- . Current understanding of multiple risk factors as the metabolic syndrome: distillation or deconstruction. Semin Neurol. 2006;26:108–116
- . Central obesity: measurement and metabolic effects. Diabetes Rev. 1997;5:8–20
- . Not all fat is alike. Lancet. 1998;351:1301–1302
- . Lipolysis: contribution from regional fat. Annu Rev Nutr. 1997;17:127–139
- Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol. 1994;73:460–468
- Waist circumference predicts insulin resistance in offspring of diabetic patients. Diabetes Nutr Metab. 2002;15:101–108
- Impact of waist circumference on the relationship between blood pressure and insulin: the Quebec Health Survey. Hypertension. 2005;45:363–367
- Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes. 1999;48:94–98
- Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes. 2000;49:2116–2125
- . Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog. Diabetes. 2003;52:2453–2460
- Visceral fat depot with limited capacity determines insulin resistance in normal dogs. Obes Res. 2003;11(suppl):A71;[abstract]
- . Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest. 1994;93:2438–2446
- . Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am J Physiol Endocrinol Metab. 2003;284:E281–E290
- Free fatty acid–induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade. Diabetes. 1999;48:1270–1274
- . Physiological hyperinsulinemia in dogs augments access of macromolecules to insulin-sensitive tissues. Diabetes. 2004;53:2741–2747
- Reduced access to insulin-sensitive tissues in dogs with obesity secondary to increased fat intake. Diabetes. 2006;55:1769–1775
- Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab. 2005;288:E454–E461
- . Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo. J Clin Invest. 2000;106:421–430
- . Burst-like control of lipolysis by the sympathetic nervous system in vivo. J Clin Invest. 2003;111:257–264
- . Importance of pulsatile changes in FFA for the enhancement of glucose output from the liver. Diabetes. 2006;55(suppl 1):4;[abstract]
- . Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why). J Hypertens. 2001;19(pt 2):523–528
- . The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104:787–794
- . Insulin resistance and impaired insulin secretion in subjects with histories of gestational diabetes mellitus. Diabetes. 1985;34:861–869
- . Pathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion. Int J Clin Pract Suppl. 2000;113:3–13
- . Pancreatic beta-cell loss and preservation in type 2 diabetes. Clin Ther. 2003;25(suppl B):B32–B46
- . Insulinemia and blood pressure: relationships in patients with primary and secondary hypertension, and with or without glucose metabolism impairment. Am J Hypertens. 1990;3:521–526
- . Atherosclerosis in diabetes: the role of hyperinsulinemia. Metabolism. 1988;37(suppl 1):1–9
- . Insulin: a novel factor in carcinogenesis. Am J Med Sci. 2002;323:140–145
PII: S0002-9343(06)01361-1
doi: 10.1016/j.amjmed.2006.11.012
© 2007 Elsevier Inc. All rights reserved.
« Previous
Next »
The American Journal of Medicine
Volume 120, Issue 2,
Supplement 1
, Pages S3-S8
, February 2007

