The American Journal of Medicine
Volume 120, Issue 7 , Pages 610-615 , July 2007

Body Weight Changes with β-Blocker Use: Results from GEMINI

  • Franz H. Messerli, MD

      Affiliations

    • St. Luke’s-Roosevelt Hospital Center, New York City
    • Corresponding Author InformationRequests for reprints should be addressed to Franz H. Messerli, MD, St. Luke’s-Roosevelt Hospital Center, Cardiology 3B-30, 1000 10th Ave., New York, NY 10019.
    • ,
  • David S.H. Bell, MB

      Affiliations

    • University of Alabama, Birmingham
    • ,
  • Vivian Fonseca, MD

      Affiliations

    • Tulane University, New Orleans, La
    • ,
  • Richard E. Katholi, MD

      Affiliations

    • St. John’s Hospital, Springfield, Ill
    • ,
  • Janet B. McGill, MD

      Affiliations

    • Washington University School of Medicine, St. Louis, Mo
    • ,
  • Robert A. Phillips, MD, PhD

      Affiliations

    • University of Massachusetts Memorial Medical Center and Medical School, Worcester
    • ,
  • Philip Raskin, MD

      Affiliations

    • University of Texas, Dallas
    • ,
  • Jackson T. Wright Jr., MD, PhD

      Affiliations

    • Case Western Reserve University, Cleveland, Ohio
    • ,
  • Sripal Bangalore, MD

      Affiliations

    • St. Luke’s-Roosevelt Hospital Center, New York City
    • ,
  • Fred K. Holdbrook, PhD

      Affiliations

    • GlaxoSmithKline, Philadelphia, Pa
    • ,
  • Mary Ann Lukas, MD

      Affiliations

    • GlaxoSmithKline, Philadelphia, Pa
    • ,
  • Karen M. Anderson, PhD

      Affiliations

    • GlaxoSmithKline, Philadelphia, Pa
    • ,
  • George L. Bakris, MD

      Affiliations

    • Rush University Medical Center, Chicago, Ill
    • ,
  • GEMINI Investigators

  • Image Result

    Carvedilol vs metoprolol tartrate: difference in mean weight change from baseline. Carvedilol therapy did not cause a significant weight increase (0.2 kg; P =.36), while metoprolol tartrate did signif

    Carvedilol vs metoprolol tartrate: difference in mean weight change from baseline. Carvedilol therapy did not cause a significant weight increase (0.2 kg; P =.36), while metoprolol tartrate did significantly increase weight from baseline (1.2 kg; P <.001). The difference between the mean weight changes was significant (P <.001). From Bakris et al.6

  • Image Result
    Carvedilol vs metoprolol tartrate: treatment-by-quartile interaction. The difference in weight change between carvedilol and metoprolol tartrate treatment was greatest in the 2 highest baseline weight

    Carvedilol vs metoprolol tartrate: treatment-by-quartile interaction. The difference in weight change between carvedilol and metoprolol tartrate treatment was greatest in the 2 highest baseline weight quartiles. (P values for difference in weight by quartiles: Quartile 1: P =.13, Quartile 2: P =.37, Quartile 3: P =.06, Quartile 4: P <.0001) The difference in weight change was greatest between carvedilol and metoprolol tartrate treatment in patients in the fourth quartile (P <.0001).

PII: S0002-9343(06)01261-7

doi: 10.1016/j.amjmed.2006.10.017

The American Journal of Medicine
Volume 120, Issue 7 , Pages 610-615 , July 2007

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