The American Journal of Medicine
Volume 120, Issue 1 , Pages 90-97 , January 2007

Trends in Management, Hospital and Long-Term Outcomes of Elderly Patients with Acute Myocardial Infarction

  • Shmuel Gottlieb, MD

      Affiliations

    • Cardiology Department, Bikur Cholim Hospital, Jerusalem
    • Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer
    • Corresponding Author InformationRequests for reprints should be addressed to Shmuel Gottlieb, MD, Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel 52621.
  • ,
  • Solomon Behar, MD

      Affiliations

    • Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer
  • ,
  • Hanoch Hod, MD

      Affiliations

    • Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer
  • ,
  • Doron Zahger, MD

      Affiliations

    • Cardiology Department, Soroka Medical Center, Beer-Sheva
  • ,
  • Jonathan Leor, MD

      Affiliations

    • Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer
  • ,
  • David Hasdai, MD

      Affiliations

    • Cardiology Department, Rabin Medical Center, Beilinson Campus, Petah-Tikva
  • ,
  • Haim Hammerman, MD

      Affiliations

    • Cardiology Department, Rambam Medical Center, Haifa
  • ,
  • Silviu Wagner, MD

      Affiliations

    • Geriatric Department, Sheba Medical Center, Tel-Hashomer
  • ,
  • Amir Sandach, MSc

      Affiliations

    • Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer
  • ,
  • Roseline Schwartz, BSc

      Affiliations

    • Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer
  • ,
  • Manfred S. Green, MD

      Affiliations

    • Israeli Center for Disease Control, Ministry of Health, Israel.
  • ,
  • Abraham Adunsky, MD

      Affiliations

    • Geriatric Department, Sheba Medical Center, Tel-Hashomer
  • ,
  • Intensive Cardiac Care Working Group of the Israel Heart Society

Received 22 March 2006 ,Revised 15 September 2006 ,Accepted 20 September 2006.

References 

  1. Goldberg RJ, Gore JM, Gurwitz JH, et al. The impact of age on the incidence and prognosis of initial acute myocardial infarction: The Worcester Heart Attack Study. Am Heart J. 1989;117:543–549
  2. Weaver WD, Litwin PE, Martin JS. Effect of age on use of thrombolytic therapy and mortality in acute myocardial infarction. J Am Coll Cardiol. 1991;18:657–662
  3. Avezum A, Makdisse M, Spencer F, et al. Impact of age on management and outcome of acute coronary syndrome: observation from the Global Registry of Acute Coronary Events (GRACE). Am Heart J. 2005;149:67–73
  4. Yan RT, Yan AT, Tan M, et al. Canadian Acute Coronary Syndromes (ACS) Registry Investigator Age-related differences in the management and outcome of patients with acute coronary syndromes. Am Heart J. 2006;151:352–359
  5. Stern S, Behar S, Leor J, et al. Presenting symptoms, admission electrocardiogram, management, and prognosis in acute coronary syndromes: differences by age. Am J Geriatr Cardiol. 2004;13:188–196
  6. Behar S, Battler A, Porath A, et al. A prospective national survey of management and clinical outcome of acute myocardial infarction in Israel. Isr Med Assoc J. 2003;5:249–254
  7. Lee PY, Alexander KP, Hammill BG, et al. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA. 2001;286:708–719
  8. Cannon CP. Elderly patients with acute coronary syndromes: higher risk and greater benefit from antithrombotic and interventional therapies. Am J Geriatr Cardiol. 2000;9:265–270
  9. Rogers WJ, Canto JG, Lambrew CT, et al. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the US from 1990 through 1999: the National Registry of Myocardial Infarction 1, 2 and 3. J Am Coll Cardiol. 2000;36:2056–2063
  10. Gottlieb S, Goldbourt U, Boyko V, et al. Improved outcome of elderly patients (≥75 years of age) with acute myocardial infarction from 1981-1983 to 1992-1994 in Israel. Circulation. 1997;95:342–350
  11. Gottlieb S, Goldbourt U, Barbash G, Behar S SPRINT and the Israeli Thrombolytic Survey Groups. Improvement in the prognosis of patients with myocardial infarction in the ‘90’s: an analysis by age subgroups. Am J Geriatr Cardiol. 1995;4:17–31
  12. Chobanian AV, Bakris G Ll, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure—The JNC 7 Report. JAMA. 2003;289:2560–2572
  13. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20:1183–1197
  14. Expert Panel on the Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. National Educational Program Second Report. Circulation. 1994;89:1329–1445
  15. Spencer FA, Lessard D, Yarzebski J, Gore JM, Goldberg RJ. Decade-long changes in the use of combination therapy at discharge for patients surviving acute myocardial infarction. Am Heart J. 2005;150:838–844
  16. Jackevicius CA, Alter D, Cox J, et al. Acute treatment of myocardial infarction in Canada 1999-2002. Can J Cardiol. 2005;21:145–152
  17. Rathore SS, Mehta RH, Wang Y, et al. Age and quality of care provided to elderly patients with acute myocardial infarction. Am J Med. 2003;114:307–315
  18. Barchielli A, Biatti E, Balzi D, et al. Age related changes in treatment strategies for acute myocardial infarction: a population based study. J Am Geriatr Soc. 2004;52:1355–1360
  19. Mehta RH, Granger CB, Alexander KP, et al. Reperfusion strategies for acute myocardial infarction in the elderly: benefits and risks. J Am Coll Cardiol. 2005;45:471–478
  20. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy in acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet. 2003;361:13–20
  21. Mehta RH, Sadiq I, Goldberg RJ, et al. GRACE Investigators Effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction. Am Heart J. 2004;147:253–259
  22. Goldenberg I, Matetzky S, Halkin A, et al. Primary angioplasty with routine stenting compared with thrombolytic therapy in elderly patients with acute myocardial infarction. Am Heart J. 2003;145:862–867
  23. Tedesco JV, Williams BA, Wright RS, et al. Baseline comorbidities and treatment strategy in elderly patients are associated with outcome of cardiogenic shock in community based population. Am Heart J. 2003;146:472–478
  24. Hochman JS, Sleeper LA, Webb JG, et al. Early revascularization in acute myocardial infarction complicated by cardiogenic shock. N Engl J Med. 1999;341:625–634
  25. Dzavick V, Sleeper LA, Webb JG, et al. SHOCK Investigators Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK Trial Registry. Eur Heart J. 2003;24:828–837
  26. Babaev A, Frederick PD, Pasta DJ, et al. Trends in management and outcomes of patients with acute myocardial infarction complicated by cardiogenic shock. JAMA. 2005;294:448–454
  27. Pickering TG. Reflections in hypertension: heart failure and hypertension: the diastolic dilemma. J Clin Hypertens. 2004;6:647–650
  28. Pccini JP, Klein L, Georghiade M, Bonow RO. New insights into diastolic heart failure: role of diabetes mellitus. Am J Med. 2004;116:64S–75S
  29. Cardiac infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J. 2000;21:1502–1513
  30. Hasdai D, Behar S, Boyko V, et al. Cardiac biomarkers and acute coronary syndromes—the Euro Heart Survey of Acute Coronary Syndromes Experience. Eur Heart J. 2003;24:1189–1194
  31. Savonitto S, Ardissino D, Granger CB, et al. Prognostic value of the admission electrocardiogram in acute coronary syndromes. JAMA. 1999;24:707–713;281:
  32. Moriel M, Behar S, Tzivoni D, et al. Working Group on Intensive Cardiac Care, Israel Heart Society Management and outcomes of elderly women and men with acute coronary syndromes in 2000 and 2002. Arch Intern Med. 2005;165:1521–1526
  33. Ben-Dor I, Hasdai D, Behar S, et al. Working group on Intensive Cardiac Care, Israel Heart Society Prognostic implications of elevated cardiac biomarkers and ST-segment depression in non-ST elevation acute coronary syndromes: lessons from the Acute Coronary Syndrome Israeli Survey (ACSIS) 2002. Heart. 2006;92:547–548

PII: S0002-9343(06)01150-8

doi: 10.1016/j.amjmed.2006.09.018

The American Journal of Medicine
Volume 120, Issue 1 , Pages 90-97 , January 2007