The American Journal of Medicine
Volume 120, Issue 5 , Page 380 , May 2007

Allopurinol for Stones: Right Drug—Wrong Reasons

  • Phulwinder K. Grover, PhD

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Phulwinder K. Grover, Division of Urology, Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia
    • ,
  • Rosemary L. Ryall, DSc

References 

  1. Grover PK, Ryall RL. Urate and calcium oxalate stones: from repute to rhetoric to reality. Miner Electrolyte Metab. 1994;20:361–370
  2. Coe FL. Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricosuria or no metabolic disorder. Ann Intern Med. 1977;87:404–410
  3. Coe FL, Lawton RL, Goldstein RB, Tembe V. Sodium urate accelerates precipitation of calcium oxalate in vitro. Proc Soc Exp Biol Med. 1975;149:926–929
  4. Pak CYC, Arnold LH. Heterogeneous nucleation of calcium oxalate by seeds of monosodium urate. Proc Soc Exp Biol Med. 1975;149:930–932
  5. Robertson WG, Knowles F, Peacock M. Urinary acid mucopolysaccharide inhibitors of calcium oxalate crystallization. In:  Fleisch H,  Robertson WG,  Smith LH,  Vahlensieck W editor. Urolithiasis Research. New York: Plenum Press; 1976;p. 331–334
  6. Coe FL, Kavalach AG. Hypercalciuria and hyperuricosuria in patients with calcium nephrolithiasis. N Engl J Med. 1974;291:1344–1350
  7. Ettinger B, Tang A, Citron JT, Livermore B, Williams T. Randomized trial of allopurinol in the prevention of calcium oxalate calculi. N Engl J Med. 1986;315:1386–1389
  8. Kallistratos G, Timmermann A, Fenner O. Zum Einfluss des Aussalzeffektes auf die Bildung von Calciumoxalat-Kristallen im menschlichen Harn. Naturwissenschaften. 1970;57:198
  9. Grover PK, Marshall VR, Ryall RL. Dissolved urate salts-out calcium oxalate in undiluted human urine in vitro: Implications for calcium oxalate stone genesis. Chem Biol. 2003;10:271–278

PII: S0002-9343(06)01020-5

doi: 10.1016/j.amjmed.2006.08.017

The American Journal of Medicine
Volume 120, Issue 5 , Page 380 , May 2007

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