The American Journal of Medicine
Volume 119, Issue 10, Supplement 1 , Pages 38-45 , October 2006

The Impact of Severe Exacerbations on Quality of Life and the Clinical Course of Chronic Obstructive Pulmonary Disease

  • Dennis E. Niewoehner, MD

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dennis E. Niewoehner, MD, Department of Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, Minnesota 55417.

References 

  1. Anthonisen NR , Manfreda J , Warren CP , Hershfield ES , Harding GK , Nelson NA . Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease . Ann Intern Med . 1987;106:196–204
  2. Niewoehner DE , Erbland ML , Deupree RH , et al. Department of Veterans Affairs Cooperative Study Group   Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease . N Engl J Med . 1999;340:1941–1947
  3. Jones PW , Willits LR , Burge PS , Calverley PM . Disease severity and the effect of fluticasone propionate on chronic obstructive pulmonary disease exacerbations . Eur Respir J . 2003;21:68–73
  4. Parker CM , Voduc N , Aaron SD , Webb KA , O’Donnell DE . Physiological changes during symptom recovery from moderate exacerbations of COPD . Eur Respir J . 2005;26:420–428
  5. Seemungal TA , Donaldson GC , Bhowmik A , Jeffries DJ , Wedzicha JA . Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease . Am J Respir Crit Care Med . 2000;161:1608–1613
  6. Davies L , Angus RM , Calverley PM . Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial . Lancet . 1999;354:456–460
  7. Jones PW . Interpreting thresholds for a clinically significant change in health status in asthma and COPD . Eur Respir J . 2002;19:398–404
  8. Wilson R , Schentag JJ , Ball P , Mandell L  068 Study Group . A comparison of gemifloxacin and clarithromycin in acute exacerbations of chronic bronchitis and long-term clinical outcomes . Clin Ther . 2002;24:639–652
  9. Spencer S , Jones PW  GLOBE Study Group . Time course of recovery of health status following an infective exacerbation of chronic bronchitis . Thorax . 2003;58:589–593
  10. Burge PS , Calverley PM , Jones PW , Spencer S , Anderson JA , Maslen TK . Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial . BMJ . 2000;320:1297–1303
  11. Spencer S , Calverley PM , Burge PS , Jones PW . Impact of preventing exacerbations on deterioration of health status in COPD . Eur Respir J . 2004;23:698–702
  12. Seemungal TA , Donaldson GC , Paul EA , Bestall JC , Jeffries DJ , Wedzicha JA . Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease . Am J Respir Crit Care Med . 1998;157:1418–1422
  13. Doll H , Grey-Amante P , Duprat-Lomon I , et al.  Quality of life in acute exacerbation of chronic bronchitis: results from a German population study . Respir Med . 2002;96:39–51
  14. Osman IM , Godden DJ , Friend JA , Legge JS , Douglas JG . Quality of life and hospital re-admission in patients with chronic obstructive pulmonary disease . Thorax . 1997;52:67–71
  15. Fan VS , Curtis JR , Tu SP , McDonell MB , Fihn SD . Using quality of life to predict hospitalization and mortality in patients with obstructive lung diseases . Chest . 2002;122:429–436
  16. Kanner RE , Anthonisen NR , Connett JE . Lower respiratory illnesses promote FEV1 decline in current smokers but not ex-smokers with mild chronic obstructive pulmonary disease: results from the Lung Health Study . Am J Respir Crit Care Med . 2001;164:358–364
  17. Donaldson GC , Seemungal TA , Bhowmik A , Wedzicha JA . Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease . Thorax . 2002;57:847–852
  18. Strassels SA , Smith DH , Sullivan SD , Mahajan PS . The costs of treating COPD in the United States . Chest . 2001;119:344–352
  19. HCUPnet, Healthcare Cost and Utilization Project . Web site of the Agency for Healthcare Research and Quality, US Dept of Health and Human Services . 2006; Available at: http://hcup.ahrq.gov/HCUPnet.asp. Accessed August 15,
  20. Hilleman DE , Dewan N , Malesker M , Friedman M . Pharmacoeconomic evaluation of COPD . Chest . 2000;118:1278–1285
  21. Sin DD , Tu JV . Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with chronic obstructive pulmonary disease . Am J Respir Crit Care Med . 2001;164:580–584
  22. Connors AF , Dawson NV , Thomas C , et al.  SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments)   Outcomes following acute exacerbation of severe chronic obstructive lung disease . [published correction appears in Am J Respir Crit Care Med. 1997;155:386] Am J Respir Crit Care Med . 1996;154:959–967
  23. Wilt TJ , Niewoehner D , Kim C , et al.  Use of Spirometry for Case Finding, Diagnosis, and Management of Chronic Obstructive Pulmonary Disease (COPD) (Summary, Evidence Report/Technology Assessment No. 121 (prepared by the Minnesota Evidence-based Practice Center, under Contract No. 290-02-0009).) . Rockville, MD: Agency for Healthcare Research and Quality; 2005; AHRQ publication 05-E017-012.
  24. Niewoehner DE , Rice K , Cote C , et al.  Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial . Ann Intern Med . 2005;143:317–326
  25. Brusasco V , Hodder R , Miravitlles M , Korducki L , Towse L , Kesten S . Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD . Thorax . 2003;58:399–404
  26. Barr RG , Bourbeau J , Camargo CA , Ram FS . Inhaled tiotropium for stable chronic obstructive pulmonary disease . Cochrane Database Syst Rev . 2005; :CD002876.
  27. van Noord JA , Aumann JL , Janssens E , et al.  Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD . Eur Respir J . 2005;26:214–222
  28. Cazzola M , Centanni S , Santus P , et al.  The functional impact of adding salmeterol and tiotropium in patients with stable COPD . Respir Med . 2004;98:1214–1221
  29. Global Initiative for Chronic Obstructive Lung Disease . Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease—Updated 2004 . Bethesda, MD: US Dept of Health and Human Services, National Institutes of Health; 2005;
  30. Howells CH , Tyler LE . Prophylactic use of influenza vaccine in patients with chronic bronchitis: a pilot trial . Lancet . 1961;2:1428–1432
  31. Wongsurakiat P , Maranetra KN , Wasi C , Kositanont U , Dejsomritrutai W , Charoenratanakul S . Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study . Chest . 2004;125:2011–2020
  32. Nichol KL , Baken L , Nelson A . Relation between influenza vaccination and outpatient visits, hospitalization, and mortality in elderly persons with chronic lung disease . Ann Intern Med . 1999;130:397–403
  33. Nichol KL , Baken L , Wuorenma J , Nelson A . The health and economic benefits associated with pneumococcal vaccination of elderly persons with chronic lung disease . Arch Intern Med . 1999;159:2437–2442
  34. Jackson LA , Neuzil KM , Yu O , et al.  Effectiveness of pneumococcal polysaccharide vaccine in older adults . N Engl J Med . 2003;348:1747–1755
  35. Sprenkle MD , Niewoehner DE , MacDonald R , Rutks I , Wilt TJ . OM-85 BV, an immunomodulatory agent, for the prevention of exacerbations in chronic obstructive pulmonary disease: a systematic review of efficacy and safety . J Chron Obstruct Pulm Dis . 2005;2:167–175
  36. Taylor SJ , Candy B , Bryar RM , et al.  Effectiveness of innovations in nurse led chronic disease management for patients with chronic obstructive pulmonary disease: systematic review of evidence . BMJ . 2005;331:485
  37. Bourbeau J , Julien M , Maltais F , et al.  Reduction of hospital utilization in patients with chronic obstructive pulmonary disease: a disease-specific self-management intervention . Arch Intern Med . 2003;163:585–591
  38. Black P , Staykova T , Chacko E , Ram FS , Poole P . Prophylactic antibiotic therapy for chronic bronchitis . Cochrane Database Syst Rev . 2003; :CD004105.
  39. Poole PJ , Black PN . Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease . Cochrane Database Syst Rev . 2003;2: :CD001287.
  40. Rabe KF , Bateman ED , O’Donnell D , Witte S , Bredenbroker D , Bethke TD . Roflumilast—an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial . Lancet . 2005;366:563–571
  41. Ringbaek TJ , Viskum K , Lange P . Does long-term oxygen therapy reduce hospitalisation in hypoxaemic chronic obstructive pulmonary disease? . Eur Respir J . 2002;20:38–42
  42. Ries AL , Kaplan RM , Myers R , Prewitt LM . Maintenance after pulmonary rehabilitation in chronic lung disease: a randomized trial . Am J Respir Crit Care Med . 2003;167:880–888
  43. Garcia-Aymerich J , Monso E , Marrades RM , et al. EFRAM Investigators   Risk factors for hospitalization for a chronic obstructive pulmonary disease exacerbation: EFRAM study . Am J Respir Crit Care Med . 2001;164:1002–1007
  44. Miravitlles M , Guerrero T , Mayordomo C , Sanchez-Agudo L , Nicolau F , Segu JL . Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: a multiple logistic regression analysis . Respiration . 2000;67:495–501
  45. Godtfredsen NS , Vesbo J , Osler M , Prescott E . Risk of hospital admission for COPD following smoking cessation and reduction: a Danish population study . Thorax . 2002;57:967–972

PII: S0002-9343(06)00927-2

doi: 10.1016/j.amjmed.2006.08.006

The American Journal of Medicine
Volume 119, Issue 10, Supplement 1 , Pages 38-45 , October 2006