The American Journal of Medicine
Volume 119, Issue 9, Supplement 1 , Pages S94-S102 , September 2006

Cognitive Functioning and Sex Steroid Hormone Gene Polymorphisms in Women at Midlife

  • Howard M. Kravitz, DO, MPH

      Affiliations

    • Department of Psychiatry, Rush University Medical Center, Chicago, Illinois
    • Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois
    • Corresponding Author InformationCorrespondence should be addressed to Howard M. Kravitz, DO, MPH, Rush University Medical Center, Department of Psychiatry, Marshall Field IV Building, 1720 West Polk Street, Chicago, Illinois 60612.
    • ,
  • Peter M. Meyer, PhD

      Affiliations

    • Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois
    • ,
  • Teresa E. Seeman, PhD

      Affiliations

    • Division of Geriatrics, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
    • ,
  • Gail A. Greendale, MD

      Affiliations

    • Division of Geriatrics, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
    • ,
  • MaryFran R. Sowers, PhD

      Affiliations

    • Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan

References 

  1. Meyer PM , Powell LH , Wilson RS , et al.   A population-based longitudinal study of cognitive functioning in the menopausal transition . Neurology . 2003;61:801–806
  2. Everson-Rose SA , Mendes de Leon CF , Bienias JL , Wilson RS , Evans DA . Early life conditions and cognitive functioning in later life . Am J Epidemiol . 2003;58:1083–1089
  3. Brody N . Intellligence . 2nd ed.. San Diego: Academic Press; 1992;
  4. Mackintosh NJ . IQ and Human Intelligence . Oxford, England: Oxford University Press; 1998;
  5. Plomin R . Quantitative trait loci and general cognitive ability . In:  Benjamin J ,  Ebstein RP ,  Belmaker RH editor. Molecular Genetics of Human Personality . New York: American Psychiatric Publishing, Inc; 2002;p. 211–230
  6. Plomin R , DeFries JC . The genetics of cognitive abilities and disabilities . Sci Am . 1998;278:62–69
  7. Plomin R . The nature and nurture of cognitive abilities . In:  Sternberg RJ editors. Advances in the Psychology of Human Intelligence . volume 4: Hillsdale, NJ: Lawrence Erlbaum Associates, Inc; 1988;p. 1–33
  8. Ostlund H , Keller E , Hurd YL . Estrogen receptor gene expression in relation to neuropsychiatric disorders . Ann N Y Acad Sci . 2003;1007:54–63
  9. Stoffel-Wagner B . Neurosteroid biosynthesis in the human brain and its clinical implications . Ann N Y Acad Sci . 2003;1007:64–78
  10. Hogervorst E , Yaffe K , Richards M , Huppert F . Hormone replacement therapy for cognitive function in postmenopausal women . Cochrane Database Syst Rev . 2002;(3):CD003122
  11. Nelson HD , Humphrey LL , Nygren P , Teutsch SM , Allan JD . Postmenopausal hormone replacement therapy: scientific review . JAMA . 2002;288:872–881
  12. Shumaker SA , Legault C , Rapp SR , et al.  WHIMS Investigators   Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women (The Women’s Health Initiative Memory Study: a randomized controlled trial) . JAMA . 2003;289:2651–2662
  13. Rapp SR , Espeland MA , Shumaker SA , et al.  WHIMS Investigators   Effect of estrogen plus progestin on global cognitive function in postmenopausal women (The Women’s Health Initiative Memory Study: a randomized controlled trial) . JAMA . 2003;289:2663–2672
  14. Shumaker SA , Legault C , Kuller L , et al.  Women’s Health Initiative Memory Study Investigators   Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women’s Health Initiative Memory Study . JAMA . 2004;291:2947–2958
  15. Espeland MA , Rapp SR , Shumaker SA , et al.  Women’s Health Initiative Memory Study Investigators   Conjugated equine estrogens and global cognitive function in postmenopausal women: Women’s Health Initiative Memory Study . JAMA . 2004;291:2958–2968
  16. Yaffe K , Lui L-Y , Grady D , Stone K , Morin P . Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women . Biol Psychiatry . 2002;51:677–682
  17. Sowers MF , Crawford SL , Sternfeld B , et al.   SWAN: a multicenter, multiethnic, community-based cohort study of women and the menopausal transition . In:  Lobo R ,  Marcus R ,  Kelsey J editor. Menopause: Biology and Pathobiology . San Diego, CA: Academic Press; 2000;p. 175–188
  18. Albert M , Smith LA , Scherr PA , Taylor JO , Evans DA , Funkenstein HH . Use of brief cognitive tests to identify individuals in the community with clinically diagnosed Alzheimer’s disease . Int J Neurosci . 1991;57:167–178
  19. Scherr PA , Albert MS , Funkenstein HH , et al.   Correlates of cognitive function in an elderly community population . Am J Epidemiol . 1988;128:1084–1101
  20. Wechsler D . Wechsler Memory Scale–Revised Manual . New York: The Psychological Corporation; 1987;
  21. Smith A . Symbol Digit Modalities Test Manual–Revised . Los Angeles: Western Psychological Services; 1982;
  22. R Development Core Team . R: A Language and Environment for Statistical Computing . Vienna, Austria: R Foundation for Statistical Computing; 2005;
  23. Efron B , Tibshirani R . Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy . Stat Sci . 1986;1:54–77
  24. Rothman KJ . No adjustments are needed for multiple comparisons . Epidemiology . 1990;1:43–46
  25. Budson AE , Price BH . Memory dysfunction . N Engl J Med . 2005;352:692–699
  26. Squire LR . Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans . [published correction appears in Psychol Rev. 1992;99:582] Psychol Rev . 1992;99:195–231
  27. Osterlund MK , Grandien K , Keller E , Hurd YL . The human brain has distinct regional expression patterns of estrogen receptor alpha mRNA isoforms derived from alternative promoters . J Neurochem . 2000;75:1390–1397
  28. Henderson VW . Hormone Therapy and the Brain: A Clinical Perspective on the Role of Estrogen . New York: Parthenon Publishing; 2000;
  29. Brandi ML , Becherini L , Gennari L , et al.   Association of estrogen receptor α gene polymorphisms with sporadic Alzheimer’s disease . Biochem Biophys Res Commun . 1999;265:335–338
  30. Isoe-Wada K , Maeda M , Yong J , et al.   Positive association between an estrogen receptor gene polymorphism and Parkinson’s disease with dementia . Eur J Neurol . 1999;6:431–435
  31. Mattila KM , Axelman K , Rinne JO , et al.   Interaction between estrogen receptor 1 and the ε4 allele of apolipoprotein E increases the risk of familial Alzheimer’s disease in women . Neurosci Lett . 2000;282:45–48
  32. Maruyama H , Toji H , Harrington CR , et al.   Lack of an association of estrogen receptor α gene polymorphisms and transcriptional activity with Alzheimer disease . Arch Neurol . 2000;57:236–240
  33. Stoffel-Wagner B , Watzka M , Steckelbroeck S , Schramm J , Bidlingmaier JF , Klingmuller D . Expression of 17β-hydroxysteroid dehydrogenase types 1, 2, 3 and 4 in the human temporal lobe . J Endocrinol . 1999;160:119–126
  34. Steckelbroeck S , Watzka M , Stoffel-Wagner B , et al.   Expression of the 17β-hydroxysteroid dehydrogenase type 5 mRNA in the human brain . Mol Cell Endocrinol . 2001;171:165–168
  35. Kemper T . Neuroanatomical and neuropathological changes during aging and dementia . In:  Albert M ,  Knoefel J editor. Clinical Neurology of Aging . 2nd ed.. New York: Oxford University Press; 1994;p. 3–67
  36. Bartzokis G , Beckson M , Lu PH , Neuchterlein KH , Edwards N , Mintz J . Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study . Arch Gen Psychiatry . 2001;58:461–465
  37. Bartzokis G . Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease . Neurobiol Aging . 2004;25:5–18
  38. Bartzokis G . Quadratic trajectories of brain myelin content: unifying construct for neuropsychiatric disorders . Neurobiol Aging . 2004;25:49–62
  39. Stoffel-Wagner B , Watzka M , Schramm J , Bidlingmaier F , Klingmuller D . Expression of CYP19 (aromatase) mRNA in different areas of the human brain . J Steroid Biochem Mol Biol . 1999;70:237–241
  40. Wozniak A , Hutchison RE , Morris CM , Hutchison JB . Neuroblastoma and Alzheimer’s disease brain cells contain aromatase activity . Steroids . 1998;63:263–267

 The Study of Women’s Health Across the Nation (SWAN) and the SWAN Repository were supported by grants from the National Institutes of Health (NIH), Department of Health and Human Services, through the National Institute on Aging, the National Institute of Nursing Research, and the NIH Office of Research on Women’s Health (Grant Nos. AG017719, NR004061, AG012505, AG012535, AG012531, AG012539, AG012546, AG012553, AG012554, and AG012495). The Sex Steroid Hormone Genetics Protocol was supported by the SWAN Repository. Work on this report also was supported by Grant No. K25 HL68139-01A1 from the National Heart, Lung, and Blood Institute to Dr. Peter M. Meyer.This report is based on samples from the SWAN DNA Repository. Scientists interested in developing studies based on this resource can find a description of the SWAN Core Repository and DNA Repository and information on obtaining access to the resources at www.swanrepository.org.Reprints are not available.

PII: S0002-9343(06)00921-1

doi: 10.1016/j.amjmed.2006.07.030

The American Journal of Medicine
Volume 119, Issue 9, Supplement 1 , Pages S94-S102 , September 2006

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