The American Journal of Medicine
Volume 120, Issue 4 , Pages 364-368 , April 2007

Outbreak of Pertussis on a College Campus

  • Allen S. Craig, MD

      Affiliations

    • Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Ga
    • Tennessee Department of Health, Nashville, Tenn
    • Corresponding Author InformationRequests for reprints should be addressed to Allen S. Craig, MD, Tennessee Department of Health, 425 5th Avenue North, Nashville, TN 37243.
    • ,
  • Seth W. Wright, MD, MPH

      Affiliations

    • Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, Tenn
    • ,
  • Kathryn M. Edwards, MD

      Affiliations

    • Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tenn
    • ,
  • John W. Greene, MD

      Affiliations

    • Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tenn
    • ,
  • MaryLou Haynes, RN

      Affiliations

    • Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, Tenn
    • ,
  • Anthony D. Dake, MD

      Affiliations

    • Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, Tenn
    • ,
  • William Schaffner, MD

      Affiliations

    • Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.

References 

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  2. Guris D, Strebel PM, Bardenheier B, et al. Changing epidemiology of pertussis in the United States: increasing reported incidence among adolescents and adults, 1990-1996. Clin Infect Dis. 1999;28:1230–1237
  3. Cromer BA, Goydos J, Hackell J, et al. Unrecognized pertussis infection in adolescents. Am J Dis Child. 1993;147:575–577
  4. Nennig ME, Shinefield HR, Edwards KM, et al. Prevalence and incidence of adult pertussis in an urban population. JAMA. 1996;275:1672–1674
  5. Robertson PW, Goldberg H, Jarvie BH, et al. Bordetella pertussis infection: a cause of persistent cough in adults. Med J Aust. 1987;146:522–525
  6. Schmitt-Grohe S, Cherry JD, Heininger U, et al. Pertussis in German adults. Clin Infect Dis. 1995;21:860–866
  7. Jackson LA, Cherry JD, Wang SP, Grayston JT. Frequency of serological evidence of Bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses. Clin Infect Dis. 2000;31:3–6
  8. Mink CM, Cherry JD, Christenson P, et al. A search for Bordetella pertussis infection in university students. Clin Infect Dis. 1992;14:464–471
  9. Murray PR, Baron EJ, Pfaller ME. Manual of Clinical Microbiology. Washington, DC: American Society for Microbiology; 1995;
  10. van der Zee A, Agterberg C, Peeters M, et al. Polymerase chain reaction assay for pertussis: simultaneous detection and discrimination of Bordetella pertussis and Bordetella parapertussis. J Clin Microbiol. 1993;31:2134–2140
  11. Centers for Disease Control and Prevention. Case definitions for infectious conditions under public health surveillance. MMWR Recomm Rep. 1997;46:1–55
  12. Strebel PM, Cochi SL, Farizo KM, et al. Pertussis in Missouri: evaluation of nasopharyngeal culture, direct fluorescent antibody testing, and clinical case definitions in the diagnosis of pertussis. Clin Infect Dis. 1993;16:276–285
  13. Patriarca PA, Biellik RJ, Sanden G, et al. Sensitivity and specificity of clinical case definitions for pertussis. Am J Public Health. 1988;78:833–836
  14. Baughman AL, Bisgard KM, Edwards KM, et al. Establishment of diagnostic cutoff points for levels of serum antibodies to pertussis toxin, filamentous hemagglutinin, and fimbriae in adolescents and adults in the United States. Clin Diagn Lab Immunol. 2004;11:1045–1053
  15. Christie CD, Glover AM, Willke MJ, Marx ML, Reising SF, Hutchinson NM. Containment of pertussis in the regional pediatric hospital during the Greater Cincinnati epidemic of 1993. Infect Control Hosp Epidemiol. 1995;16:556–563
  16. Pertussis outbreaks—Massachusetts and Maryland, 1992. MMWR Morb Mortal Wkly Rep. 1993;42:197–200
  17. Mattoo S, Cherry JD. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev. 2005;18:326–382
  18. Dworkin MS. Adults are whooping, but are internists listening?. Ann Intern Med. 2005;142:832–835
  19. Senzilet LD, Halperin SA, Spika JS, et al. Pertussis is a frequent cause of prolonged cough illness in adults and adolescents. Clin Infect Dis. 2001;32:1691–1697
  20. Hewlett EL, Edwards KM. Clinical practice (Pertussis—not just for kids). N Engl J Med. 2005;352:1215–1222
  21. Heininger U, Schmidt-Schlapfer G, Cherry JD, Stehr K. Clinical validation of a polymerase chain reaction assay for the diagnosis of pertussis by comparison with serology, culture, and symptoms during a large pertussis vaccine efficacy trial. Pediatrics. 2000;105:E31
  22. Lievano FA, Reynolds MA, Waring AL, et al. Issues associated with and recommendations for using PCR to detect outbreaks of pertussis. J Clin Microbiol. 2002;40:2801–2805
  23. Ward JI, Cherry JD, Chang SJ, et al. Efficacy of an acellular pertussis vaccine among adolescents and adults. N Engl J Med. 2005;353:1555–1563
  24. Lee GM, Lett S, Schauer S, et al. Societal costs and morbidity of pertussis in adolescents and adults. Clin Infect Dis. 2004;39:1572–1580
  25. Edwards KM. Overview of pertussis: focus on epidemiology, sources of infection, and long term protection after infant vaccination. Pediatr Infect Dis J. 2005;24:S104–S108
  26. Halperin SA. Pertussis—a disease and vaccine for all ages. N Engl J Med. 2005;353:1615–1617

PII: S0002-9343(06)00835-7

doi: 10.1016/j.amjmed.2006.06.035

The American Journal of Medicine
Volume 120, Issue 4 , Pages 364-368 , April 2007

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