The American Journal of Medicine
Volume 120, Issue 1 , Pages 26-32 , January 2007

Antihypertensive Medication Adherence in the Department of Veterans Affairs

  • David Siegel, MD, MPH

      Affiliations

    • Medical Service, VA Northern California Health Care System, Martinez and Sacramento, Calif
    • School of Medicine, University of California, Davis, Calif
    • Corresponding Author InformationRequests for reprints should be addressed to David Siegel, MD, MPH, Chief, Medical Service (111), Department of Veterans Affairs NCHCS, 10535 Hospital Way, Mather, CA 95655.
  • ,
  • Julio Lopez, PharmD

      Affiliations

    • Pharmacy Service, VA Northern California Health Care System, Martinez and Sacramento, Calif
    • School of Pharmacy, University of California, San Francisco, Calif
    • School of Pharmacy, University of the Pacific, Stockton, Calif.
  • ,
  • Joy Meier, PharmD

      Affiliations

    • Pharmacy Service, VA Northern California Health Care System, Martinez and Sacramento, Calif
    • School of Pharmacy, University of the Pacific, Stockton, Calif.

References 

  1. Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee (The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure). JAMA. 2003;289:2560–2572
  2. Fields LE, Burt VL, Cutler JA, et al. The burden of adult hypertension in the United States 1999 to 2000: a rising tide. Hypertension. 2004;44:398–404
  3. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension (Final results of the Systolic Hypertension in the Elderly Program). JAMA. 1991;265:3255–3264
  4. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)ALLHAT officers and coordinators for the ALLHAT collaborative research group. The antihypertensive and lipid-lowering treatment to prevent heart attack trail. JAMA. 2002;288:2981–2997
  5. Blood Pressure Lowering Treatment Trialists’ Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overview of randomized trials. Lancet. 2003;362:1527–1535
  6. Veterans Administration Cooperative Study Group on Antihypertensive Agents. Effect of treatment on morbidity in hypertension (II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg). JAMA. 1970;213:1143–1152
  7. Burt VL, Whelton P, Roccella EJ, et al. Prevalence of hypertension in the US adult population: results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension. 1995;25:305–313
  8. Egan BM, Basile JN. Controlling blood pressure in 50% of all hypertensive patients: an achievable goal in the healthy people 2010 report?. J Invest Med. 2003;51:373–385
  9. Nelson CR, Knapp DA. Trends in antihypertensive drug therapy of ambulatory patients by US office-based physicians. Hypertension. 2000;36:600–603
  10. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353:487–497
  11. Balkrishnan R. Predictors of medication adherence in the elderly. Clin Ther. 1998;40:764
  12. Benner JS, Glynn RJ, Mogun H, et al. Long-term persistence in use of statin therapy in elderly patients. JAMA. 2002;288:455–461
  13. Shalansky SJ, Levy AR. Effect of number of medications on cardiovascular therapy adherence. Ann Pharmacother. 2002;36:1532–1539
  14. Steiner JF, Koepsell TD, Fihn SD, Inui TS. A general method of compliance assessment using centralized pharmacy records (Description and validation). Med Care. 1988;26:814–823
  15. Sikka R, Xia F, Aubert RE. Estimating medication persistency using administrative claims data. Am J Manag Care. 2005;11:449–457
  16. Andrade SE, Kahler KH, Frech F, Chan KA. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf. 2006;8:565–574
  17. Rizzo JA, Simons WR. Variations in compliance among hypertensive patients by drug class: implications for health care costs. Clin Ther. 1997;19:1446–1457
  18. Caro JJ, Speckman JL, Salas M, et al. Effect of initial drug choice on persistence with antihypertensive therapy (The importance of actual practice data). Can Med Assoc J. 1999;160:41–46
  19. Bloom BS. Continuation of initial antihypertensive medication after 1 year of therapy. Clin Ther. 1998;20:671–681
  20. Fletcher AE, Bulpitt CJ, Chase DM, et al. Quality of life with three antihypertensive treatments-cilazapril, atenolol, nifedipine. Hypertension. 1992;19:499–507
  21. Bulpitt CJ, Connor M, Schulte M, Fletcher AE. Bisoprolol and nifedipine retard in elderly hypertensive patients: effect on quality of life. J Hum Hypertens. 2000;14:205–212
  22. Carney RM, Freeland KE, Eisen SA, et al. Major depression and medication adherence in elderly patients with coronary artery disease. Health Psychol. 1995;14:88–90
  23. Eagle K, Kline-Rogers E, Goodman S, et al. Adherence to evidence based therapies after discharge for acute syndromes (An ongoing, prospective, observational study). Am J Med. 2004;117:73–81
  24. Gregorie JP, Moisan J, Guibert R, et al. Determinants of discontinuation of new courses of antihypertensive medications. J Clin Epidemiol. 2002;55:728–735
  25. Catalan VS, LeLorier J. Predictors of long-term persistence on statins in a subsidized clinical population. Value Health. 2000;3:417–426
  26. DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW. Patient adherence and medical treatment outcomes. Med Care. 2002;40:794–811
  27. Gryfe CI, Gryfe BM. Drug therapy of the aged: the problem of compliance and the roles of physicians and pharmacists. J Am Geriatr Soc. 1984;32:301–307
  28. Dezi CM. A retrospective study of persistence with single-pill combination therapy vs. concurrent two-pill therapy in patients with hypertension. Manag Care. 2000;9(Suppl):S2–S6
  29. Thiebaud R, Patel BV, Nichol MB, Berenmeim DM. The effect of switching on compliance and persistence: the case of statin treatment. Am J Manag Care. 2005;11:670–674
  30. Dimatteo MR, Sherbourne CD, Hays RD, et al. Physicians’ characteristics influence patients’ adherence to medical treatment: results from the medical outcome study. Health Psychol. 1993;12:93–102
  31. Oluvarius NF, Beck-Nielsen H, Anderson AH, et al. Randomized controlled trial of structured personal care of type 2 diabetes mellitus. BMJ. 2001;323:970–975
  32. Murray M, Bodenheimer T, Rittenhouse D, Grumbach K. Improving timely access to primary care: case studies of the advanced access model. JAMA. 2003;289:1042–1046
  33. McDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions. JAMA. 2002;288:2868–2879
  34. Heidenreich PA. Patient adherence: the next frontier in quality improvement. Am J Med. 2004;117:130–132
  35. Vrijens B, Goetghebeur E. Comparing compliance patterns between randomized treatments. Control Clin Trials. 1997;18:187–203
  36. Feldman R, Bacher M, Campbell N, et al. Adherence to pharmacologic management of hypertension. Can J Public Health. 1998;89:I16–I18

 The views expressed in the article do not necessarily represent the views of the Department of Veterans Affairs or of the United States Government.

PII: S0002-9343(06)00776-5

doi: 10.1016/j.amjmed.2006.06.028

The American Journal of Medicine
Volume 120, Issue 1 , Pages 26-32 , January 2007