The American Journal of Medicine
Volume 119, Issue 9 , Pages 751-759 , September 2006

Fruit and Vegetable Juices and Alzheimer’s Disease: The Kame Project

  • Qi Dai, MD, PhD

      Affiliations

    • Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt Center for Health Services Research, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, VA Tennessee Valley Geriatric Research, Education, and Clinical Center, Nashville, Tenn
    • Corresponding Author InformationRequests for reprints should be addressed to Qi Dai, MD, PhD, Division of General Internal Medicine, S-1124 Medical Center North, Nashville, TN 37232-2587.
  • ,
  • Amy R. Borenstein, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa
  • ,
  • Yougui Wu, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa
  • ,
  • James C. Jackson, PsyD

      Affiliations

    • Clinical Research Center for Excellence, VA Tennessee Valley Health Care System, Nashville, Tenn
    • Division of Allergy, Pulmonary, and Critical Care Medicine, Nashville, Tenn
    • Department of Psychiatry, Vanderbilt University, Nashville, Tenn
  • ,
  • Eric B. Larson, MD, MPH

      Affiliations

    • Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, Wash

,Revised 22 March 2006

References 

  1. Butterfield DA, Drake J, Pocernich C, Castegna A. Evidence of oxidative damage in Alzheimer’s disease brain: central role for amyloid beta-peptide. Trends Mol Med. 2001;7(12):548–554
  2. Honda K, Casadesus G, Petersen RB, Perry G, Smith MA. Oxidative stress and redox-active iron in Alzheimer’s disease. Ann N Y Acad Sci. 2004;1012:179–182
  3. Markesbery WR. Oxidative stress hypothesis in Alzheimer’s disease. Free Radic Biol Med. 1997;23(1):134–147
  4. Petersen RC, Thomas RG, Grundman M, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352(23):2379–2388
  5. Luchsinger JA, Tang MX, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol. 2003;60(2):203–208
  6. Morris MC, Beckett LA, Scherr PA, et al. Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alzheimer Dis Assoc Disord. 1998;12(3):121–126
  7. Zandi PP, Anthony JC, Khachaturian AS, et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol. 2004;61(1):82–88
  8. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA. 2002;287(24):3223–3229
  9. Morris MC, Evans DA, Bienias JL, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA. 2002;287(24):3230–3237
  10. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79(5):727–747
  11. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr. 2000;130(8S Suppl):2073S–2085S
  12. Bates BP, Morris JR, Crandall PG. Principles and Practices of Small- and Medium- Scale Fruit Processing. Gainesville, FL: Food Science and Human Nutrition Department, University of Florida; 2001;
  13. Bazemore R, Rouseff R, Naim M. Linalool in orange juice: origin and thermal stability. J Agric Food Chem. 2003;51(1):196–199
  14. Lindsay J, Laurin D, Verreault R, et al. Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol. 2002;156(5):445–453
  15. Forster DP, Newens AJ, Kay DW, Edwardson JA. Risk factors in clinically diagnosed presenile dementia of the Alzheimer type: a case-control study in northern England. J Epidemiol Community Health. 1995;49(3):253–258
  16. Rogers MA, Simon DG. A preliminary study of dietary aluminium intake and risk of Alzheimer’s disease. Age Ageing. 1999;28(2):205–209
  17. Laurin D, Masaki KH, Foley DJ, White LR, Launer LJ. Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study. Am J Epidemiol. 2004;159(10):959–967
  18. Lugasi A, Hovari J. Antioxidant properties of commercial alcoholic and nonalcoholic beverages. Nahrung. 2003;47(2):79–86
  19. Manach C, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Remesy C. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr. 2003;57(2):235–242
  20. Bub A, Watzl B, Blockhaus M, et al. Fruit juice consumption modulates antioxidative status, immune status and DNA damage. J Nutr Biochem. 2003;14(2):90–98
  21. Vinson JA, Liang X, Proch J, Hontz BA, Dancel J, Sandone N. Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease. Adv Exp Med Biol. 2002;505:113–122
  22. Heo HJ, Lee CY. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem. 2004;52:7514–7517
  23. Heo HJ, Kim DO, Shin SC, Kim MJ, Kim BG, Shin DH. Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection. J Agric Food Chem. 2004;52(6):1520–1525
  24. Nakayama T, Yamada M, Osawa T, Kawakishi S. Suppression of active oxygen-induced cytotoxicity by flavonoids. Biochem Pharmacol. 1993;45(1):265–267
  25. Patil CS, Singh VP, Satyanarayan PS, Jain NK, Singh A, Kulkarni SK. Protective effect of flavonoids against aging- and lipopolysaccharide-induced cognitive impairment in mice. Pharmacology. 2003;69(2):59–67
  26. O’Byrne DJ, Devaraj S, Grundy SM, Jialal I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr. 2002;76(6):1367–1374
  27. Graves AB, Larson EB, Edland SD, et al. Prevalence of dementia and its subtypes in the Japanese American population of King County, Washington state (The Kame Project). Am J Epidemiol. 1996;144(8):760–771
  28. Larson EB, McCurry SM, Graves AB. Standardization of the clinical diagnosis of the dementia syndrome and its subtypes in a cross-national study: the Ni-Hon-Sea experience. J Gerontol. 1998;53:M313–M319
  29. Teng EL, Hasegawa K, Homma A, et al. The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. Int Psychogeriatr. 1994;6(1):45–58
  30. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982;140:566–572
  31. Morris JC, Heyman A, Mohs RC, et al. The consortium to establish a registry for Alzheimer’s disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology. 1989;39:1159–1165
  32. Welsh KA, Butters N, Mohs RC, et al. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology. 1994;44(4):609–614
  33. Kiernan RJ, Mueller J, Langston JW, Van Dyke C. The Neurobehavioral Cognitive Status Examination: a brief but quantitative approach to cognitive assessment. Ann Intern Med. 1987;107(4):481–485
  34. Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological Test Battery. Tempe, AZ: Neuropsychology Press; 1985;
  35. Shipley WC. Institute of Living Scale. Los Angeles, CA: Western Psychological Services Corp; 1946;
  36. Tiffin J. Purdue Pegboard: Examiner Manual. Chicago, IL: Science Research Associates; 1968;
  37. Wechsler D. Wechsler Adult Intelligence Scale—Revised. New York: Psychological Corporation; 1981;
  38. Wechsler D. Wechsler Memory Scale—Revised. New York: Psychological Corporation; 1987;
  39. In: Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: American Psychiatric Press; 1994;
  40. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology. 1984;34(7):939–944
  41. Roman GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies (Report of the NINDS-AIREN International Workshop). Neurology. 1993;43(2):250–260
  42. Chui HC, Victoroff JI, Margolin D, Jagust W, Shankle R, Katzman R. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer’s Disease Diagnostic and Treatment Centers. Neurology. 1992;42(3 Pt 1):473–480
  43. Hankin JH, Wilkens LR. Development and validation of dietary assessment methods for culturally diverse populations. Am J Clin Nutr. 1994;59(1 Suppl):198S–200S
  44. Hankin JH, Nomura AM, Lee J, Hirohata T, Kolonel LN. Reproducibility of a diet history questionnaire in a case-control study of breast cancer. Am J Clin Nutr. 1983;37(6):981–985
  45. Hankin JH, Wilkens LR, Kolonel LN, Yoshizawa CN. Validation of a quantitative diet history method in Hawaii. Am J Epidemiol. 1991;133(6):616–628
  46. Hankin JH. Dietary methods for estimating vitamin A and carotene intakes in epidemiologic studies of cancer. J Can Diet Assoc. 1987;47:219–224
  47. Doty RL, Marcus A, Lee WW. Development of the 12-item Cross-Cultural Smell Identification Test (CC-SIT). Laryngoscope. 1996;106(3 Pt 1):353–356
  48. Graves AB, Bowen JD, Rajaram L, et al. Impaired olfaction as a marker for cognitive decline: interaction with apolipoprotein E epsilon4 status. Neurology. 1999;53(7):1480–1487
  49. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16(3):1215
  50. Emi M, Wu LL, Robertson MA, et al. Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics. 1988;3(4):373–379
  51. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 1990;31(3):545–548
  52. Hosmer DW, Lemeshow S. Applied Survival Analysis (Regression Modeling of Time to Even Data). New York: Wiley; 1999;
  53. Korn EL, Graubard BI, Midthune D. Time-to-event analysis of longitudinal follow-up of a survey: choice of the time-scale. Am J Epidemiol. 1997;145(1):72–80
  54. Borenstein AR, Wu Y, Mortimer JA, et al. Developmental and vascular risk factors for Alzheimer’s disease. Neurobiol Aging. 2005;26(3):325–334
  55. Evans DA, Morris MC. Is a randomized trial of antioxidants in the primary prevention of Alzheimer disease warranted?. Alzheimer Dis Assoc Disord. 1996;10(Suppl 1):45–49
  56. Grundman M, Grundman M, Delaney P. Antioxidant strategies for Alzheimer’s disease. Proc Nutr Soc. 2002;61(2):191–202
  57. Orgogozo JM, Dartigues JF, Lafont S, et al. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Revue Neurologique. 1997;153:185–192
  58. Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, Dartigues JF. Intake of flavonoids and risk of dementia. Eur J Epidemiol. 2000;16(4):357–363
  59. Smith CD, Carney JM, Starke-Reed PE, et al. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci U S A. 1991;88(23):10540–10543
  60. Nunomura A, Perry G, Pappolla MA, et al. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer’s disease. J Neurosci. 1999;19(6):1959–1964
  61. Smith MA, Hirai K, Hsiao K, et al. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem. 1998;70(5):2212–2215
  62. Opazo C, Huang X, Cherny RA, et al. Metalloenzyme-like activity of Alzheimer’s disease beta-amyloid (Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)). J Biol Chem. 2002;277(43):40302–40308
  63. Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell. 1994;77(6):817–827
  64. Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ. Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004;36(5):592–604
  65. Ortiz D, Shea TB. Apple juice prevents oxidative stress induced by amyloid-beta in culture. J Alzheimers Dis. 2004;6(1):27–30
  66. Nakayama T. Suppression of hydroperoxide-induced cytotoxicity by polyphenols. Cancer Res. 1994;54(7 Suppl):1991s–1993s
  67. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med. 2001;30(4):433–446
  68. Rogers EJ, Milhalik S, Orthiz D, Shea TB. Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice. J Nutr Health Aging. 2004;8(2):92–97
  69. Hodgson JM, Croft KD, Mori TA, Burke V, Beilin LJ, Puddey IB. Regular ingestion of tea does not inhibit in vivo lipid peroxidation in humans. J Nutr. 2002;132(1):55–58
  70. O’Reilly JD, Mallet AI, McAnlis GT, et al. Consumption of flavonoids in onions and black tea: lack of effect on F2-isoprostanes and autoantibodies to oxidized LDL in healthy humans. Am J Clin Nutr. 2001;73(6):1040–1044
  71. Sanchez-Moreno C, Cano MP, de Ancos B, et al. High-pressurized orange juice consumption affects plasma vitamin C, antioxidative status and inflammatory markers in healthy humans. J Nutr. 2003;133(7):2204–2209
  72. Meagher EA, Barry OP, Lawson JA, Rokach J, FitzGerald GA. Effects of vitamin E on lipid peroxidation in healthy persons. JAMA. 2001;285(9):1178–1182
  73. Kiefer I, Prock P, Lawrence C, et al. Supplementation with mixed fruit and vegetable juice concentrates increased serum antioxidants and folate in healthy adults. J Am Coll Nutr. 2004;23(3):205–211
  74. Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B(12) and folate in relation to the development of Alzheimer’s disease. Neurology. 2001;56(9):1188–1194

 This research was supported by the National Institutes of Health, National Institute on Aging grants R01 AG09769 and UO1 AG06781.

PII: S0002-9343(06)00677-2

doi: 10.1016/j.amjmed.2006.03.045

The American Journal of Medicine
Volume 119, Issue 9 , Pages 751-759 , September 2006