The American Journal of Medicine
Volume 120, Issue 9 , Page e21 , September 2007

Opioid-induced Androgen Deficiency Discussion in Opioid Contracts

References 

  1. Arnold R, Han P, Seltzer D. Opioid contracts in chronic nonmalignant pain management: objectives and uncertainties. Am J Med. 2006;119:292–296
  2. Daniell H. Hypogonadism in men consuming sustained-action oral opioids. J Pain. 2002;3:377–384
  3. Rajagopal A, Vassilopoulou-Sellin R, Palmer JL, et al. Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer. 2004;100:851–858
  4. Daniell H, Lentz R, Mazer N. Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency. J Pain. 2006;7:200–210
  5. Roberts LJ, Finch PM, Pullan PT, et al. Sex hormone suppression by intrathecal opioids: a prospective study. Clin J Pain. 2002;18:144–148
  6. Abs R, Verhelst J, Maeyaert J, et al. Endocrine consequences of long-term intrathecal administration of opioids. J Clin Endocrinol Metab. 2000;85:2215–2222
  7. Paice J, Penn R, Ryan W. Altered sexual function and decreased testosterone in patients receiving intraspinal opioids. J Pain Symptom Manage. 1994;9:126–131
  8. Paice JA, Penn RD. Amenorrhea associated with intraspinal morphine. J Pain Symptom Manage. 1995;10:582–583
  9. Schmittner J, Schroeder JR, Epstein DH, Preston KL. Menstrual cycle length during methadone maintenance. Addiction. 2005;100:829–836
  10. Daniell HW. Opioid endocrinopathy in women consuming prescribed sustained-action opioids for control of non-malignant pain. J Pain. In press.

PII: S0002-9343(06)00614-0

doi: 10.1016/j.amjmed.2006.05.027

The American Journal of Medicine
Volume 120, Issue 9 , Page e21 , September 2007

Article Tools