The American Journal of Medicine
Volume 119, Issue 7, Supplement 1 , Pages S69-S73 , July 2006

Mechanisms and Therapy of Osmotic Demyelination

  • Takashi Murase, MD, PhD

      Affiliations

    • Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    • Corresponding Author InformationRequests for reprints should be addressed to Takashi Murase, MD, PhD, Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
    • ,
  • Yoshihisa Sugimura, MD

      Affiliations

    • Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    • ,
  • Seiko Takefuji, MD

      Affiliations

    • Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    • Department of Metabolic Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Yutaka Oiso, MD, PhD

      Affiliations

    • Department of Metabolic Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Yoshiharu Murata, MD, PhD

      Affiliations

    • Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

References 

  1. Laureno R , Karp BI . Myelinolysis after correction of hyponatremia . Ann Intern Med . 1997;126:57–62
  2. Ashrafian H , Davey P . A review of the causes of central pontine myelinosis (yet another apoptotic illness?) . Eur J Neurol . 2001;8:103–109
  3. Sterns RH , Cappuccio JD , Silver SM , Cohen EP . Neurologic sequelae after treatment of severe hyponatremia (a multicenter perspective) . J Am Soc Nephrol . 1994;4:1522–1530
  4. Adrogue HJ , Madias NE . Hyponatremia . N Engl J Med . 2000;342:1581–1589
  5. Lampl C , Yazdi K . Central pontine myelinolysis . Eur Neurol . 2002;47:3–10
  6. Lohr JW . Osmotic demyelination syndrome following correction of hyponatremia (association with hypokalemia) . Am J Med . 1994;96:408–413
  7. Adler S , Verbalis JG , Williams D . Effect of rapid correction of hyponatremia on the blood-brain barrier of rats . Brain Res . 1995;679:135–143
  8. Verbalis JG , Gullans SR . Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats . Brain Res . 1991;567:274–282
  9. Baker EA , Tian Y , Adler S , Verbalis JG . Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia . Exp Neurol . 2000;165:221–230
  10. Verbalis JG , Martinez AJ . Neurological and neuropathological sequelae of correction of chronic hyponatremia . Kidney Int . 1991;39:1274–1282
  11. Neuwelt EA , Barnett PA , Bigner DD , Frenkel EP . Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent (the factor of the blood-brain barrier) . Proc Natl Acad Sci USA . 1982;79:4420–4423
  12. Sugimura Y , Murase T , Takefuji S , et al.   Protective effect of dexamethasone on osmotic-induced demyelination in rats . Exp Neurol . 2005;192:178–183
  13. Decaux G , Soupart A . Treatment of symptomatic hyponatremia . Am J Med Sci . 2003;326:25–30

PII: S0002-9343(06)00496-7

doi: 10.1016/j.amjmed.2006.05.010

The American Journal of Medicine
Volume 119, Issue 7, Supplement 1 , Pages S69-S73 , July 2006

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