The American Journal of Medicine
Volume 119, Issue 12 , Pages 1005-1012 , December 2006

Valerian for Sleep: A Systematic Review and Meta-Analysis

  • Stephen Bent, MD

      Affiliations

    • Osher Center for Integrative Medicine, University of California, San Francisco
    • Department of Medicine, San Francisco Veterans Affairs Medical Center
    • Corresponding Author InformationRequests for reprints should be addressed to Stephen Bent, MD, General Internal Medicine Section, San Francisco VAMC, 111-A1, 4150 Clement St, San Francisco, CA 94121.
    • ,
  • Amy Padula, MS

      Affiliations

    • Department of Medicine, San Francisco Veterans Affairs Medical Center
    • ,
  • Dan Moore, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, University of California, San Francisco.
    • ,
  • Michael Patterson, MS

      Affiliations

    • Osher Center for Integrative Medicine, University of California, San Francisco
    • ,
  • Wolf Mehling, MD

      Affiliations

    • Osher Center for Integrative Medicine, University of California, San Francisco

Received 4 October 2005 ,Accepted 22 February 2006.

References 

  1. Ancoli-Israel S, Roth T. Characteristics of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. I. Sleep. 1999;22(Suppl 2):S347–S353
  2. Sateia MJ, Doghramji K, Hauri PJ, Morin CM. Evaluation of chronic insomnia (An American Academy of Sleep Medicine review). Sleep. 2000;23:243–308
  3. Ohayon M. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6:97–111
  4. Shochat T, Umphress J, Israel AG, Ancoli-Israel S. Insomnia in primary care patients. Sleep. 1999;22(Suppl 2):S359–S365
  5. Holbrook AM, Crowther R, Lotter A, Cheng C, King D. The diagnosis and management of insomnia in clinical practice: a practical evidence-based approach. CMAJ. 2000;162:216–220
  6. Morin CM, Culbert JP, Schwartz SM. Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy. Am J Psychiatry. 1994;151:1172–1180
  7. Houghton PJ. The scientific basis for the reputed activity of valerian. J Pharm Pharmacol. 1999;51:505–512
  8. Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Adv Data. 2004;1–19
  9. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996;17:1–12
  10. Egger M, Davey-Smith G, Altman DG. Systematic Reviews in Health Care. London: BMJ Publishing Group; 2001;
  11. Begg D, Berlin JA. Publication bias: a problem in interpreting medical data. J R Stat Soc Ser A. 1988;151:419–463
  12. Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry. 2000;33:47–53
  13. Schulz H, Stolz C, Müller J. The effect of valerian extract on sleep polygraphy in poor sleepers: a pilot study. Pharmacopsychiatry. 1994;27:147–151
  14. Balderer G, Borbély AA. Effect of valerian on human sleep. Psychopharmacology. 1985;87:406–409
  15. Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Medica. 1985;53:144–148
  16. Francis AJ, Dempster RJ. Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial. Phytomedicine. 2002;9:273–279
  17. Coxeter PD, Schluter PJ, Eastwood HL, Nikles CJ, Glasziou PP. Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials. Complement Ther Med. 2003;11:215–222
  18. Farag NH, Mills PJ. A randomised-controlled trial of the effects of a traditional herbal supplement on sleep onset insomnia. Complement Ther Med. 2003;11:223–225
  19. Diaper A, Hindmarch I. A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults. Phytother Res. 2004;18:831–836
  20. Kamm-Kohl AV, Jansen W, Brockmann P. Moderne Baldriantherapie gegen nervose storungen im senium. Medwelt. 1984;35:1450–1454
  21. Jacobs BP, Bent S, Tice JA, Blackwell T, Cummings SR. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine (Baltimore). 2005;84:197–207
  22. Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on “reaction time, alertness and concentration” in volunteers. Pharmacopsychiatry. 1999;32:235–241
  23. Cerny A, Schmid K. Tolerability and efficacy of valerian/lemon balm in healthy volunteers (a double-blind, placebo-controlled, multicentre study). Fitotherapia. 1999;70:221–228
  24. Vorbach EU. Therapie von insomnien: wirksamkeit und vertraglichkeit eines Baldrianpraparats. Psychopharmakotherapie. 1996;3:109–115
  25. Leathwood PD, Chauffard F, Heck E, Munoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav. 1982;17:65–71
  26. Jansen W. Doppelblindstudie mit Baldrisedon. Therapiewoche. 1977;27:2779–2786
  27. Delsignore R, Orlando S, Costi D, Baroni M, Butturini U. Avaliacao clinica comparativa com placebo de um extrato estabilizado de valeriana. Farmacologia Clinica. 1992;104:191–196
  28. Richman A, Witkowski JP. 4th Annual Herbal Products Sales Survey. Whole Foods. 1998;21:19–26
  29. Richman A, Witkowski JP. 5th Annual Herbal Product Sales Survey. Whole Foods. 1999;22:49–56
  30. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193–213
  31. Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2:297–307
  32. Rotblatt M, Ziment I. In: Evidenced-Based Herbal Medicine. Philadelphia: Hanley & Belfus Inc; 2002;p. 355–359
  33. Product Review: Valerian Supplements. ConsumerLab; 2004;Available at: www.consumerlab.com. Accessed February 16, 2006.
  34. Linde K, Jonas WB, Melchart D, Willich S. The methodological quality of randomized controlled trials of homeopathy, herbal medicine, and acupuncture. Int J Epidemiol. 2001;30:526–531
  35. McCall WV, D’Agostino R, Dunn A. A meta-analysis of sleep changes associated with placebo in hypnotic clinical trials. Sleep Med. 2003;4:57–62
  36. Dundar Y, Boland A, Strobl J, et al. Newer hypnotic drugs for the short-term management of insomnia: a systematic review and economic evaluation. Health Technol Assess. 2004;8:1–125iii-x
  37. Ioannidis JP, Evans SJ, Gotzsche PC, et al. Better reporting of harms in randomized trials: an extension of the CONSORT statement. Ann Intern Med. 2004;141:781–788
  38. Moher D, Schulz KF, Altman DG. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Clin Oral Investig. 2003;7:2–7
  39. Weaver TE, Laizner AM, Evans LK, et al. An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep. 1997;20:835–843

 This work was supported by Grant Number 1 K08 ATO1338-01 (Dr Bent) from the National Center for Complementary and Alternative Medicine.

PII: S0002-9343(06)00275-0

doi: 10.1016/j.amjmed.2006.02.026

The American Journal of Medicine
Volume 119, Issue 12 , Pages 1005-1012 , December 2006

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