The American Journal of Medicine
Volume 119, Issue 8 , Pages 684-692 , August 2006

Predischarge C-Reactive Protein and 1-year Outcome After Acute Coronary Syndromes

This paper was presented in part at the American Heart Association Scientific Sessions, on November 8, 2004.

  • Philippe Gabriel Steg, MD

      Affiliations

    • Department of Cardiology, Hôpital Bichat, Paris, France
    • Corresponding Author InformationRequests for reprints should be addressed to Philippe Gabriel Steg, MD, Hôpital Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    • ,
  • Philippe Ravaud, MD, PhD

      Affiliations

    • Department of Epidemiology, Biostatistics, and Clinical Research, Hôpital Bichat, Paris, France
    • ,
  • Alain Tedgui, PhD

      Affiliations

    • INSERM U-541, Hôpital Lariboisière, Paris, France
    • ,
  • Jacques Puel, MD

      Affiliations

    • Department of Cardiology, Hôpital Rangueil, Toulouse, France
    • ,
  • Dominique Moyse, MD

      Affiliations

    • Consultant in Biostatistics, Paris, France
    • ,
  • Emmanuelle Curaudeau, MS

      Affiliations

    • Department of Biostatistics, Bristol-Myers Squibb, Rueil-Malmaison, France
    • ,
  • Steven W. Quentzel, MD

      Affiliations

    • Cardiovascular Department, Bristol-Myers Squibb, Rueil-Malmaison, France.
    • ,
  • ELISCOR Investigators

  • Image Result

    Study flow chart. ACS = acute coronary syndrome; CABG = coronary artery bypass graft surgery; CRP = C-reactive protein; hs-CRP = high-sensitivity C-reactive protein; ICU, intensive care unit.

    Study flow chart. ACS = acute coronary syndrome; CABG = coronary artery bypass graft surgery; CRP = C-reactive protein; hs-CRP = high-sensitivity C-reactive protein; ICU, intensive care unit.

  • Image Result

    C-reactive protein level at discharge from hospital. Mean (standard) 20.0 (28.4) mg/L; range 0.20-280.60 mg/L. Q25 4.01, Q50 9.50, Q75 24.67 mg/L. Q33.3 5.20, Q66.6 17.37 mg/L. hs-CRP = high-sensitivi

    C-reactive protein level at discharge from hospital. Mean (standard) 20.0 (28.4) mg/L; range 0.20-280.60 mg/L. Q25 4.01, Q50 9.50, Q75 24.67 mg/L. Q33.3 5.20, Q66.6 17.37 mg/L. hs-CRP = high-sensitivity C-reactive protein.

  • Image Result
    Postdischarge outcomes at 1 year by predischarge C-reactive protein tertile. Log-rank test P = .6979.

    Postdischarge outcomes at 1 year by predischarge C-reactive protein tertile. Log-rank test P = .6979.

  • Image Result
    Binary primary endpoints at 1 year by C-reactive protein tertile.

    Binary primary endpoints at 1 year by C-reactive protein tertile.

  • Image Result
    Distribution of hs-C-reactive protein values in patients with versus without outcome events (death, myocardial infarction, unstable angina, revascularization, stroke or transient ischemic attack). Box

    Distribution of hs-C-reactive protein values in patients with versus without outcome events (death, myocardial infarction, unstable angina, revascularization, stroke or transient ischemic attack). Box shows mean, upper and lower quartiles; whiskers show highest and lowest observations. All outliers are represented by small boxes.

  • Image Result
    Receiver operating characteristic analysis for prediction of the primary endpoint at 1 year. C statistic = 0.5129.

    Receiver operating characteristic analysis for prediction of the primary endpoint at 1 year. C statistic = 0.5129.

 Supported by an unrestricted grant from Bristol-Myers Squibb, France. ELISCOR was supported by an unrestricted grant from Bristol-Myers Squibb, Rueil-Malmaison, France.The complete list of ELISCOR Investigators is in the Appendix.

PII: S0002-9343(06)00202-6

doi: 10.1016/j.amjmed.2006.02.018

The American Journal of Medicine
Volume 119, Issue 8 , Pages 684-692 , August 2006

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