The American Journal of Medicine
Volume 120, Issue 2 , Pages 165-171 , February 2007

The Association of Methamphetamine Use and Cardiomyopathy in Young Patients

  • Khung-Keong Yeo, MBBS

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu
    • Corresponding Author InformationAddress for correspondence and reprints: Khung-Keong Yeo, MBBS Division of Cardiovascular Medicine University of California, Davis Medical Center, 4860 Y Street, Suite 2820, Sacramento, CA 95817. Telephone: (916) 7343764; Fax: (916) 7348394.
    • ,
  • Mevan Wijetunga, MD

      Affiliations

    • Division of Cardiology, Washington Hospital Center, Washington, DC
    • ,
  • Hiroki Ito, MD

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu
    • ,
  • Jimmy T. Efird, Ph.D, M.Sc.

      Affiliations

    • Department of Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco
    • Asia Pacific Institute of Tropical Medicine and Infectious Diseases, John A. Burns School of Medicine, Honolulu, Hawaii
    • Biostatistics and Data Management Facility, John A. Burns School of Medicine, Honolulu, Hawaii
    • ,
  • Kevin Tay, MD

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu
    • ,
  • Todd B. Seto, MD, MPH, FACC

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu
    • ,
  • Kavitha Alimineti, M.Sc.

      Affiliations

    • Biostatistics and Data Management Facility, John A. Burns School of Medicine, Honolulu, Hawaii
    • ,
  • Chieko Kimata, MPH

      Affiliations

    • Biostatistics and Data Management Facility, John A. Burns School of Medicine, Honolulu, Hawaii
    • ,
  • Irwin J. Schatz, MD, FACC

      Affiliations

    • Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu

References 

  1. NIDA Research Report - Methamphetamine abuse and addiction: NIH Publication No. 02-4210. NIDA Research Report; Printed April 1998, Reprinted January 2002.
  2. Office of Applied Studies. Results from the 2002 national survey on drug use and health: national findings (DHHS Publication No. SMA 04-3964, NSDUH Series H-25). Rockville, MD: Substance Abuse and Mental Health Services Administration; 2003;
  3. Office of Applied Studies. Emergency department trends from Drug Abuse Warning Network, Final Estimates 1995-2002 (DHHS Publication No. SMA 03-3780, DAWN Series D-24). Rockville, MD: Substance Abuse and Mental Health Services Administration; 2003;
  4. Alcohol and Drug Abuse Division. Hawaii Department of Health. Substance abuse in Hawaii. Adult population household telephone survey. (1998). 2000;Kapolei, HI
  5. Wijetunga M, Seto T, Lindsay J, Schatz I. Crystal methamphetamine-associated cardiomyopathy: tip of the iceberg?. J Toxicol Clin Toxicol. 2003;41:981–986
  6. Robinson M, Turnipseed S, Glatter K. Methamphetamine-associated cardiomyopathy: A previously unrecognized cause of heart failure. American Heart Association Annual Scientific Sessions. 2004;(abstract) New Orleans
  7. Maruta T, Nihira M, Tomita Y. [Histopathological study on acute poisoning of methamphetamine, morphine or cocaine] Nihon Arukoru Yakubutsu Igakkai Zasshi. 1997;32:122–138
  8. Maeno Y, Iwasa M, Inoue H, et al. Direct effects of methamphetamine on hypertrophy and microtubules in cultured adult rat ventricular myocytes. Forensic Sci Int. 2000;113:239–243
  9. Karch SB, Stephens BG, Ho CH. Methamphetamine-related deaths in San Francisco: demographic, pathologic, and toxicologic profiles. J Forensic Sci. 1999;44:359–368
  10. Kaiho M, Ishiyama I. Morphological study of acute myocardial lesions experimentally induced by methamphetamine. Nippon Hoigaku Zasshi. 1989;43:460–468
  11. Jacobs LJ. Reversible dilated cardiomyopathy induced by methamphetamine. Clin Cardiol. 1989;12:725–727
  12. Islam MN, Kuroki H, Hongcheng B, et al. Cardiac lesions and their reversibility after long term administration of methamphetamine. Forensic Sci Int. 1995;75:29–243
  13. Hong R, Matsuyama E, Nur K. Cardiomyopathy associated with the smoking of crystal methamphetamine. Jama. 1991;265:1152–1154
  14. He SY, Matoba R, Fujitani N, et al. Cardiac muscle lesions associated with chronic administration of methamphetamine in rats. Am J Forensic Med Pathol. 1996;17:155–162
  15. Logan BK, Fligner CL, Haddix T. Cause and manner of death in fatalities involving methamphetamine. J Forensic Sci. 1998;43:28–34
  16. Kalant H, Kalant OJ. Death in amphetamine users: causes and rates. Can Med Assoc J. 1975;112:299–304
  17. Smith HJ, Roche AH, Jausch MF, Herdson PB. Cardiomyopathy associated with amphetamine administration. Am Heart J. 1976;91:792–797
  18. Derlet RW, Rice P, Horowitz BZ, Lord RV. Amphetamine toxicity: experience with 127 cases. J Emerg Med. 1989;7:157–161
  19. Lucas PB, Gardner DL, Wolkowitz OM, et al. Methylphenidate-induced cardiac arrhythmias. N Engl J Med. 1986;315:1485
  20. Ragland AS, Ismail Y, Arsura EL. Myocardial infarction after amphetamine use. Am Heart J. 1993;125:247–249
  21. Wijetunga M, Bhan R, Lindsay J, Karch S. Acute coronary syndrome and crystal methamphetamine use: a case series. Hawaii Med J. 2004;63:8–1325
  22. Turnipseed SD, Richards JR, Kirk JD, et al. Frequency of acute coronary syndrome in patients presenting to the emergency department with chest pain after methamphetamine use. J Emerg Med. 2003;24:369–373
  23. Davis GG, Swalwell CI. Acute aortic dissections and ruptured berry aneurysms associated with methamphetamine abuse. J Forensic Sci. 1994;39:1481–1485
  24. Schaiberger PH, Kennedy TC, Miller FC, et al. Pulmonary hypertension associated with long-term inhalation of “crank” methamphetamine. Chest. 1993;104:614–616
  25. Kosten TRHL. Drugs of abuse. In:  Katzung BG editors. Basic & Clinical Pharmacology. 8th ed. Norwalk: Appleton & Lange; 2000;p. 532–548

PII: S0002-9343(06)00197-5

doi: 10.1016/j.amjmed.2006.01.024

The American Journal of Medicine
Volume 120, Issue 2 , Pages 165-171 , February 2007

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