Impact of Guideline-Concordant Empiric Antibiotic Therapy in Community-Acquired Pneumonia

Frei, Christopher R.; Restrepo, Marcos I.; Mortensen, Eric M.; Burgess, David S.

doi:10.1016/j.amjmed.2006.02.014

« Previous Next »The American Journal of Medicine
Volume 119, Issue 10 , Pages 865-871, October 2006

Impact of Guideline-Concordant Empiric Antibiotic Therapy in Community-Acquired Pneumonia

Christopher R. Frei, PharmD, MSc
- University of Texas at Austin College of Pharmacy, Austin, Tex
- University of Texas Health Science Center at San Antonio, San Antonio, Tex
Marcos I. Restrepo, MD, MSc
- University of Texas Health Science Center at San Antonio, San Antonio, Tex
- Veterans Evidence-Based Research Dissemination and Implementation Center, San Antonio, Tex
- South Texas Veterans Health Care System, San Antonio, Tex.
Eric M. Mortensen, MD, MSc
- University of Texas Health Science Center at San Antonio, San Antonio, Tex
- Veterans Evidence-Based Research Dissemination and Implementation Center, San Antonio, Tex
- South Texas Veterans Health Care System, San Antonio, Tex.
David S. Burgess, PharmD
- University of Texas at Austin College of Pharmacy, Austin, Tex
- University of Texas Health Science Center at San Antonio, San Antonio, Tex
- Requests for reprints should be addressed to David S. Burgess, PharmD, Clinical Pharmacy Programs-MSC 6220, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900.

Abstract

Purpose

We evaluated the impact of guideline-concordant empiric antibiotic therapy on time to clinical stability, time to switch therapy, length of hospital stay, and mortality among patients with community-acquired pneumonia.

Methods

This is a retrospective cohort study of all adult community-acquired pneumonia patients managed at 5 community hospitals from November 1, 1999 to April 30, 2000. Patients were stratified into guideline-concordant and discordant groups as defined by the 2001 American Thoracic Society and the 2003 Infectious Diseases Society of America guidelines. Time to clinical stability, time to switch therapy, length of hospital stay, and in-hospital mortality were evaluated in per-protocol and intention-to-treat stepwise regression models that included the outcome as the dependent variable, guideline-concordant antibiotic therapy as the independent variable, and Pneumonia Severity Index score as a covariate.

Results

Of the 631 evaluable patients, 357 (57%) received guideline-concordant empiric antibiotic therapy. Groups were similar with respect to age, sex, comorbidities, severity of illness, and processes of care. Guideline-concordant antibiotic therapy was associated with a significant decrease in time to switch therapy (P ≤.01), length of hospital stay (P ≤.01), and in-hospital mortality (P=.04) for both per-protocol and intention-to-treat analyses. In addition, guideline-concordant antibiotic therapy was associated with a significant decrease in time to clinical stability for intention-to-treat analysis only (P=.03).

Conclusions

Among hospitalized community-acquired patients, guideline-concordant antibiotic therapy is associated with improved in-hospital survival and shorter time to clinical stability, time to switch therapy, and length of hospital stay.

Keywords: Community-acquired pneumonia, Antibiotics, In-hospital mortality, Hospital length of stay, Time-to-clinical stability, Time-to-switch therapy