The American Journal of Medicine
Volume 119, Issue 9 , Pages 768-776 , September 2006

Laryngeal Cancer and Gastroesophageal Reflux Disease: A Case-Control Study

  • Michael F. Vaezi, MD, PhD, MSepi

      Affiliations

    • Department of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tenn
    • Corresponding Author InformationRequests for reprints should be addressed to Michael F. Vaezi, MD, PhD, MSepi, Department of Gastroenterology, Vanderbilt University Medical Center, 1501 TVC, 1301 22nd Ave. South, Nashville, TN 37232-5280.
  • ,
  • Mohammed A. Qadeer, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio
  • ,
  • Rocio Lopez, MS, MPH

      Affiliations

    • Quantitative Health Sciences, Cleveland Clinic Foundation
  • ,
  • Natalie Colabianchi, PhD

      Affiliations

    • Department of Epidemiology, Case Western Reserve University, Cleveland, Ohio

References 

  1. Cann CI, Fried MP, Rothman KJ. Epidemiology of squamous cell cancer of the head and neck. Otolaryngol Clin North Am. 1985;18:367–388
  2. Landis S, Murray T, Bolden S, Wingo P. Cancer statistics, 1998. CA Cancer J Clin. 1998;48:6–29
  3. Rothman KJ, Cann CI, Flanders W, et al. Epidemiology of laryngeal cancer. Epidemiol Rev. 1980;2:195–209
  4. Wynder EL, Stellman SD. Comparative epidemiology of tobacco-related cancers. Cancer Res. 1977;37:4608–4622
  5. Muir C, Weinland L. Upper aerodigestive tract cancers. Cancer. 1995;75:147–153
  6. Spitz MR, Fueger JJ, Goepfert H, et al. Squamous cell carcinoma of the upper aerodigestive tract (A case comparison analysis). Cancer. 1988;61:203–208
  7. Berrino F World Health Organization, International Agency for Research on Cancer, Commission of the European Communities. Survival of cancer patients in Europe: the EUROCARE-2 study. Lyon: International Agency for Research on Cancer; 1999;IARC scientific publications no. 151.
  8. Copper MP, Jovanovic A, Nauta JJP, et al. Role of genetic factors in the etiology of squamous cell carcinoma of the head and neck. Arch Otolaryngol. 1995;121:157–160
  9. Wynder EL, Convey LS, Mabuchi K, et al. Environmental factors in cancer of larynx: a second look. Cancer. 1976;38:1591–1601
  10. Brown LM, Mason TJ, Pickle LW, et al. Occupational risk factors for laryngeal cancer on the Texas Gulf Coast. Cancer Res. 1988;48:1960–1964
  11. Flanders WD, Rothman KJ. Occupational risk for laryngeal cancer. Am J Public Health. 1982;72:369–372
  12. Franceschi S, Munoz N, Bosch XF, Snijders PJ, Walboomers JM. Human papillomavirus and cancers of upper aerodigestive tract: a review of epidemiologic and experimental evidence. Cancer Epidemiol Biomarkers Prev. 1996;5:567–575
  13. Fontham ET. Protective dietary factors and lung cancer. Int J Epidemiol. 1990;19:S32–S42
  14. Olson NR. Effects of stomach acid on the larynx. Proc Am Laryngol Assoc. 1983;104:108–112
  15. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease: a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope. 1991;101(53):1–78
  16. Morrison MD. Is chronic gastroesophageal reflux a causative factor in glottic carcinoma?. Otolaryngol Head Neck Surg. 1988;99:370–373
  17. Ward PH, Hanson DG. Reflux as an etiological factor of carcinoma of the laryngopharynx. Laryngoscope. 1988;98:1195–1199
  18. Copper MP, Smit CF, Stanojcic LD, Devriese PP, Schouwenburg PF, Mathus-Vliegen LM. High incidence of laryngopharyngeal reflux in patients with head and neck cancer. Laryngoscope. 2000;110:1007–1011
  19. Lewin JS, Gillenwater AM, Garrett JD, et al. Characterization of laryngopharyngeal reflux in patients with premalignant or early carcinomas of the larynx. Cancer. 2003;97:1010–1014
  20. El-Serag HB, Hepworth EJ, Lee P, Sonnenberg A. Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer. Am J Gastroenterol. 2001;96:2013–2018
  21. Qadeer MA, Colabianchi N, Vaezi MF. Is GERD a risk factor for laryngeal cancer?. Laryngoscope. 2005;115:486–491
  22. Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics. 1996. CA Cancer J Clin. 1996;46:5–27
  23. Wasfie T, Newman R. Laryngeal carcinoma in black patients. Cancer. 1988;61:167
  24. El-Serag HB, Petersen NJ, Carter J, et al. Gastroesophageal reflux among different racial groups in the United States. Gastroenterology. 2004;126:1692–1699
  25. Moore C. Cigarette smoking and cancer of mouth, pharynx and larynx: a continuing study. JAMA. 1987;218:553–558
  26. [No authors listed] Tobacco use—United States, 1900-1999. MMWR Morb Mortal Wkly Rep. 1999;48:986–993Erratum in: MMWR Morb Mortal Wkly Rep. 1999;48:1027
  27. Holtmann G. Reflux disease: the disorder of the third millennium. Eur J Gastroenterol Hepatol. 2001;13(Suppl 1):S5–S11
  28. Chen MY, Ott DJ, Casolo BJ, Moghazy KM, Koufman JA. Correlation of laryngeal and pharyngeal carcinomas and 24-hour pH monitoring of the esophagus and pharynx. Otolaryngol Head Neck Surg. 1998;119:460–462(retraction in Chen MY, Ott DJ, Koufman JA. Otolaryngol Head Neck Surg. 1999;121:168)
  29. Gallup Organization National Survey. Heartburn Across America. Princeton, NJ: Gallup Organization; 1988;

PII: S0002-9343(06)00159-8

doi: 10.1016/j.amjmed.2006.01.019

The American Journal of Medicine
Volume 119, Issue 9 , Pages 768-776 , September 2006