The American Journal of Medicine
Volume 119, Issue 9 , Pages 786-790 , September 2006

Change in Lipid Profile in Celiac Disease: Beneficial Effect of Gluten-Free Diet

  • Pardeep Brar, MD

      Affiliations

    • Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY
  • ,
  • Grace Y. Kwon, MD

      Affiliations

    • Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY
  • ,
  • Steve Holleran, BA

      Affiliations

    • Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY.
  • ,
  • Diane Bai, MD

      Affiliations

    • Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY
  • ,
  • Alan R. Tall, MD

      Affiliations

    • Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY
  • ,
  • Rajasekhar Ramakrishnan, ScD

      Affiliations

    • Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY.
  • ,
  • Peter H.R. Green, MD

      Affiliations

    • Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY
    • Corresponding Author InformationRequests for reprints should be addressed to Peter H. R. Green, MD, 161 Fort Washington Avenue, New York, NY 10032.

References 

  1. Green PH, Jabri B. Coeliac disease. Lancet. 2003;362(9381):383–391
  2. West J, Logan RF, Hill PG, et al. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut. 2003;52(7):960–965
  3. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003;163(3):286–292
  4. Vuoristo M, Tarpila S, Miettinen TA. Serum lipids and fecal steroids in patients with celiac disease: effects of gluten-free diet and cholestyramine. Gastroenterology. 1980;78(6):1518–1525
  5. Ciacci C, Cirillo M, Giorgetti G, et al. Low plasma cholesterol: a correlate of nondiagnosed celiac disease in adults with hypochromic anemia. Am J Gastroenterol. 1999;94(7):1888–1891
  6. Ciampolini M, Bini S. Serum lipids in celiac children. J Pediatr Gastroenterol Nutr. 1991;12(4):459–460
  7. Bai D, Brar P, Holleran S, et al. Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in men. Scand J Gastroenterol. 2005;40(2):183–187
  8. Rosenthal E, Hoffman R, Aviram M, et al. Serum lipoprotein profile in children with celiac disease. J Pediatr Gastroenterol Nutr. 1990;11(1):58–62
  9. Marsh MN. Gluten, major histocompatibility complex, and the small intestine (A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’)). Gastroenterology. 1992;102(1):330–354
  10. Mediene S, Hakem S, Bard JM, et al. Serum lipoprotein profile in Algerian patients with celiac disease. Clin Chim Acta. 1995;235(2):189–196
  11. Capristo E, Addolorato G, Mingrone G, et al. Low-serum high-density lipoprotein-cholesterol concentration as a sign of celiac disease. Am J Gastroenterol. 2000;95(11):3331–3332
  12. Pillan MN, Spandrio S, Sleiman I, et al. Effects of a gluten-free diet on serum lipids and lipoprotein (a) levels in a group of patients with celiac disease. J Pediatr Gastroenterol Nutr. 1994;18(2):183–185
  13. Green PH, Tall AR, Glickman RM. Rat intestine secretes discoid high density lipoprotein. J Clin Invest. 1978;61(2):528–534
  14. Green PH, Glickman RM. Intestinal lipoprotein metabolism. J Lipid Res. 1981;22(8):1153–1173
  15. Floren CH, Alm P. Defective synthesis of apolipoprotein A-I in jejunal mucosa in coeliac disease. Scand J Gastroenterol. 1988;23(7):856–860
  16. Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?. BMJ. 1994;308(6925):367–372
  17. Miller M, Seidler A, Kwiterovich PO, Pearson TA. Long-term predictors of subsequent cardiovascular events with coronary artery disease and ‘desirable’ levels of plasma total cholesterol. Circulation. 1992;86(4):1165–1170
  18. Fonarow GC, Watson KE. High-density lipoprotein cholesterol as a therapeutic target to reduce cardiovascular events. Am Heart J. 2004;147(6):939–941
  19. Whorwell PJ, Alderson MR, Foster KJ, Wright R. Death from ischaemic heart-disease and malignancy in adult patients with coeliac disease. Lancet. 1976;2(7977):113–114
  20. West J, Logan RF, Card TR, et al. Risk of vascular disease in adults with diagnosed coeliac disease: a population-based study. Aliment Pharmacol Ther. 2004;20(1):73–79
  21. West J, Logan RF, Card TR, et al. Fracture risk in people with celiac disease: a population-based cohort study. Gastroenterology. 2003;125(2):429–436
  22. Tata LJ, Card TR, Logan RF, et al. Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study. Gastroenterology. 2005;128(4):849–855
  23. Peters U, Askling J, Gridley G, et al. Causes of death in patients with celiac disease in a population-based Swedish cohort. Arch Intern Med. 2003;163(13):1566–1572
  24. Kumar PJ, Walker-Smith J, Milla P, et al. The teenage coeliac: follow up study of 102 patients. Arch Dis Child. 1988;63(8):916–920
  25. Hankey GL, Holmes GK. Coeliac disease in the elderly. Gut. 1994;35(1):65–67
  26. Butterworth JR, Banfield LM, Iqbal TH, Cooper BT. Factors relating to compliance with a gluten-free diet in patients with coeliac disease: comparison of white Caucasian and South Asian patients. Clin Nutr. 2004;23(5):1127–1134
  27. Boden WE. High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from Framingham to the Veterans Affairs High-Density Lipoprotein Intervention Trial. Am J Cardiol. 2000;86(12A):19L–22L
  28. Maron DJ. The epidemiology of low levels of high-density lipoprotein cholesterol in patients with and without coronary artery disease. Am J Cardiol. 2000;86(12A):11L–14L
  29. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143–3421

PII: S0002-9343(06)00032-5

doi: 10.1016/j.amjmed.2005.12.025

The American Journal of Medicine
Volume 119, Issue 9 , Pages 786-790 , September 2006