The American Journal of Medicine
Volume 119, Issue 4, Supplement 1 , Pages S18-S24 , April 2006

Improving Compliance and Persistence with Bisphosphonate Therapy for Osteoporosis

  • Ronald D. Emkey, MD

      Affiliations

    • Radiant Research, Wyomissing, Pennsylvania, USA
    • Corresponding Author InformationRequests for reprints should be addressed to Ronald D. Emkey, MD, Radiant Research, 1235 Penn Avenue, Suite 200, Wyomissing, Pennsylvania 19610.
    • ,
  • Mark Ettinger, MD

      Affiliations

    • Radiant Research, Wyomissing, Pennsylvania, USA
    • Regional Osteoporosis Center, Stuart, Florida, USA

References 

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  13. Caro JJ , Ishak KJ , Huybrechts KF , Raggio G , Naujoks C . The impact of compliance with osteoporosis therapy on fracture rates in actual practice . Osteoporos Int . 2004;15:1003–1008
  14. Siris E, Rosen CJ, Harris ST, Abbott TA III, Barr CE, Silverman SL. Adherence to bisphosphonate therapy: relationship to bone fractures at 24 months in women with post-menopausal osteoporosis. Presented at the National Osteoporosis Foundation 6th International Symposium on Osteoporosis; April 6–9, 2005; Washington, DC.
  15. Clowes JA , Peel NF , Eastell R . The impact of monitoring on adherence and persistence with antiresorptive treatment for postmenopausal osteoporosis (a randomized controlled trial) . J Clin Endocrinol Metab . 2004;89:1117–1123
  16. Emkey R , Delmas PD , Goemaere S , et al.   Changes in bone mineral density following discontinuation or continuation of alendronate therapy in glucocorticoid-treated patients (a retrospective, observational study) . Arthritis Rheum . 2003;48:1102–1108
  17. Cox ER , Jernigan C , Coons SJ , Draugalis JL . Medicare beneficiaries’ management of capped prescription benefits . Med Care . 2001;39:296–301
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  19. Strickland WJ , Strickland DL . Coping with the cost of care (an exploratory study of lower income minorities in the rural South) . [abstract] Family Community Health . 1995;18:51
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  24. Ettinger MP , Gallagher R , Amonkar M , et al.   Medication persistence is improved with less frequent dosing of bisphosphonates, but remains inadequate . Arthritis Rheum . 2004;15(suppl):S513
  25. Fosamax (alendronate sodium) tablet and oral solution [prescribing information] . Whitehouse Station, NJ: Merck & Co., Inc; 2004;
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  28. Brown JP , Kendler DL , McClung MR , et al.   The efficacy and tolerability of risedronate once a week for the treatment of postmenopausal osteoporosis . Calcif Tissue Int . 2002;71:103–111
  29. Schnitzer T , Bone HG , Crepaldi G , et al.  Alendronate Once-Weekly Study Group   Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis . Aging (Milano) . 2000;12:1–12
  30. Miller PD , McClung MR , Macovei L , et al.   Monthly oral ibandronate therapy in postmenopausal osteoporosis (1-year results from the MOBILE study) . J Bone Miner Res . 2005;20:1315–1322
  31. Silverman S, Greenwald M, Hawker G, et al. Once-monthly oral ibandronate (Boniva) dosing is highly efficacious in postmenopausal osteoporosis: 2-year results from MOBILE. Presented at the American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting; November 15, 2005; San Diego, CA.

PII: S0002-9343(05)01199-X

doi: 10.1016/j.amjmed.2005.12.019

The American Journal of Medicine
Volume 119, Issue 4, Supplement 1 , Pages S18-S24 , April 2006

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