The American Journal of Medicine
Volume 119, Issue 3 , Pages 267-274 , March 2006

Hereditary Angioedema: New Findings Concerning Symptoms, Affected Organs, and Course

  • Konrad Bork, MD

      Affiliations

    • Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    • Corresponding Author InformationRequests for reprints should be addressed to Konrad Bork, MD, Universitaets-Hautklinik, Langenbeckstr. 1, 55131 Mainz, Germany.
    • ,
  • Gabriele Meng, MD

      Affiliations

    • Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    • ,
  • Petra Staubach, MD

      Affiliations

    • Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    • ,
  • Jochen Hardt, MD

      Affiliations

    • Department of Psychosomatic Medicine and Psychotherapy, Johannes Gutenberg University, Mainz, Germany

References 

  1. Quincke HI . Über akutes umschriebenes Hautödem . Monatsh Prakt Dermatol . 1882;1:129–131
  2. Osler W . Hereditary angioneurotic edema . Am J Med Sci . 1888;95:362–367
  3. Donaldson VH , Evans RR . A biochemical abnormality in hereditary angioneurotic edema (absence of serum inhibitor of C1-esterase) . Am J Med . 1963;31:37–44
  4. Tosi M . Molecular genetics of C1 inhibitor . Immunobiology . 1998;199:358–365
  5. Drouet C , Blanch A , Roche O , et al.   HAE (Mutation analysis of the C1INH gene) . J Allergy Clin Immunol . 2004;114:S66–S74
  6. Bork K , Barnstedt S-E , Koch P , Traupe H . Hereditary angioedema with normal C1-inhibitor activity in women . Lancet . 2000;356:213–217
  7. Landerman NS . Hereditary angioneurotic edema . J Allergy Clin Immunol . 1962;33:316–329
  8. Frank MM , Gelfand JA , Atkinson JP . Hereditary angioedema (the clinical syndrome and its management) . Ann Intern Med . 1976;84:580–593
  9. Atkinson JP . Diagnosis and management of hereditary angioedema (HAE) . Ann Allergy . 1979;42:348–352
  10. Cicardi M , Bergamaschini L , Marasini B , et al.   Hereditary angioedema (an appraisal of 104 cases) . Am J Med Sci . 1982;284:2–9
  11. Agostoni A , Cicardi M . Hereditary and acquired C1-inhibitor deficiency (biological and clinical characteristics in 235 patients) . Medicine (Baltimore) . 1992;71:206–215
  12. Cicardi M , Zingale L . Clinical manifestation of HAE . J Allergy Clin Immunol . 2004;114:S55–S58
  13. Bork K , Siedlecki K , Bosch S , Schopf RE , Kreuz W . Asphyxiation by laryngeal edema in patients with hereditary angioedema . Mayo Clin Proc . 2000;75:349–354
  14. Bork K , Barnstedt S-E . Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema . J Am Dent Assoc . 2003;134:1088–1093
  15. Bork K , Hardt J , Schicketanz KH , Ressel N . Clinical studies of sudden upper airway obstruction in patients with hereditary angioedema due to C1 esterase inhibitor deficiency . Arch Intern Med . 2003;163:1229–1235
  16. Bork K , Koch P . Episodes of severe dyspnea due to snoring-induced recurrent edema of the soft palate in hereditary angioedema . J Am Acad Dermatol . 2001;45:968–969
  17. Sabroe RA , Kobza Black A . Angiotensin-converting enzyme (ACE) inhibitors and angio-oedema . Br J Dermatol . 1997;136:153–158
  18. Cicardi M , Zingale LC , Bergamaschini L , Agostoni A . Angioedema associated with angiotensin-converting enzyme inhibitor use . Arch Intern Med . 2004;164:910–913
  19. Van Dellen RG , Myers RP . Bladder involvement in hereditary angioedema . Mayo Clin Proc . 1980;55:277–278
  20. Nielsen EW , Gran JT , Straume B , et al.   Hereditary angio-edema (new clinical observations and autoimmune screening, complement and kallikrein-kinin analyses) . J Intern Med . 1996;239:119–130
  21. Bork K , Fischer B , Dewald G . Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by oral contraceptives or hormone replacement therapy . Am J Med . 2003;114:294–298
  22. Bork K , Meng G , Staubach P , Hardt J . Treatment with C1 inhibitor concentrate in abdominal pain attacks of patients with hereditary angioedema . Transfusion . 2005;45:1774–1784

PII: S0002-9343(05)01081-8

doi: 10.1016/j.amjmed.2005.09.064

The American Journal of Medicine
Volume 119, Issue 3 , Pages 267-274 , March 2006

Article Tools

* Image Usage & Resolution