The American Journal of Medicine
Volume 119, Issue 8 , Pages e3-e5 , August 2006

Rituximab-induced Elimination of Acquired Angioedema Due to C1-Inhibitor Deficiency

  • Marcel Levi, MD

      Affiliations

    • Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
    • Corresponding Author InformationRequests for reprints should be addressed to Marcel Levi, MD, Department of Internal Medicine, Academic Medical Centre F-4, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
    • ,
  • C. Erik Hack, MD

      Affiliations

    • Department of Clinical Chemistry, Free University Medical Center, Amsterdam, the Netherlands
    • ,
  • Marinus H. van Oers, MD

      Affiliations

    • Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

References 

  1. Agostoni A, Cicardi M. Hereditary and acquired C1-inhibitor deficiency (biological and clinical characteristics in 235 patients). Medicine (Baltimore). 1992;71:206–215
  2. Markovic SN, Inwards DJ, Frigas EA, Phyliky RP. Acquired C1 esterase inhibitor deficiency. Ann Intern Med. 2000;132:144–150
  3. Jackson J, Sim RB, Whelan A, Feighery C. An IgG autoantibody which inactivates C1-inhibitor. Nature. 1986;323:722–724
  4. Cicardi M, Zingale LC, Pappalardo E, Folcioni A, Agostoni A. Autoantibodies and lymphoproliferative diseases in acquired C1-inhibitor deficiencies. Medicine (Baltimore). 2003;82:274–281
  5. Carugati A, Pappalardo E, Zingale LC, Cicardi M. C1-inhibitor deficiency and angioedema. Mol Immunol. 2001;38:161–173
  6. D’Incan M, Tridon A, Ponard D, et al. Acquired angioedema with C1 inhibitor deficiency (is the distinction between type I and type II still relevant?). Dermatology. 1999;199:227–230
  7. Cicardi M, Beretta A, Colombo M, Gioffre D, Cugno M, Agostoni A. Relevance of lymphoproliferative disorders and of anti-C1 inhibitor autoantibodies in acquired angio-oedema. Clin Exp Immunol. 1996;106:475–480
  8. Chevailler A, Arlaud G, Ponard D, et al. C-1-inhibitor binding monoclonal immunoglobins in three patients with acquired angioneurotic edema. J Allergy Clin Immunol. 1996;97:998–1008
  9. Agostoni A, Aygoren-Pursun E, Binkley KE, et al. Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. J Allergy Clin Immunol. 2004;114:S51–S131
  10. Smith MR. Rituximab (monoclonal anti-CD20 antibody) (mechanisms of action and resistance). Oncogene. 2003;22:7359–7368
  11. Silverman GJ, Weisman S. Rituximab therapy and autoimmune disorders (prospects for anti-B cell therapy). Arthritis Rheum. 2003;48:1484–1492
  12. McLaughlin P, Grillo-Lopez AJ, Link BK, et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma (half of patients respond to a four-dose treatment program). J Clin Oncol. 1998;16:2825–2833
  13. Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:235–242
  14. Edwards JC, Cambridge G. Prospects for B-cell-targeted therapy in autoimmune disease. Rheumatology (Oxford). 2005;44:151–156
  15. Stasi R, Pagano A, Stipa E, Amadori S. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood. 2001;98:952–957
  16. Looney RJ, Anolik JH, Campbell D, et al. B cell depletion as a novel treatment for systemic lupus erythematosus (a phase I/II dose-escalation trial of rituximab). Arthritis Rheum. 2004;50:2580–2589
  17. Edwards JC, Szczepanski L, Szechinski J, et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004;350:2572–2581
  18. Ziakas PD, Giannouli S, Psimenou E, Evangelia K, Tzioufas AG, Voulgarelis M. Acquired angioedema (a new target for rituximab). Haematologica. 2004;89:ELT13

PII: S0002-9343(05)00860-0

doi: 10.1016/j.amjmed.2005.09.018

The American Journal of Medicine
Volume 119, Issue 8 , Pages e3-e5 , August 2006

Article Tools

* Image Usage & Resolution