Rituximab-induced Elimination of Acquired Angioedema Due to C1-Inhibitor Deficiency

Effect of the administration of anti-CD20 antibodies (indicated with arrows) in 3 patients with acquired C1-inhibitor deficiency (patient A: ▴ and black bars, patient B: ■ and striped bars, patient C: • and white bars) on plasma levels of C1-inhibitor and C4, frequency of serious angioedema attacks (upper airway edema, facial edema, severe edema of extremities or genitals, and severe abdominal attacks) and the monthly requirement for C1-inhibitor concentrate (in units).