The American Journal of Medicine
Volume 118, Issue 11 , Pages 1287.e1-1287.e7 , November 2005

Obstructive intramural coronary amyloidosis and myocardial ischemia are common in primary amyloidosis

  • Michelle A. Neben-Wittich, MD

      Affiliations

    • Department of Internal Medicine, Mayo Clinic, Rochester, Minn
  • ,
  • Christopher M. Wittich, PharmD, MD

      Affiliations

    • Department of Internal Medicine, Mayo Clinic, Rochester, Minn
  • ,
  • Paul S. Mueller, MD

      Affiliations

    • Division of General Internal Medicine, Mayo Clinic, Rochester, Minn
    • Corresponding Author InformationRequests for reprints should be addressed to Paul S. Mueller, MD, Division of General Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.
  • ,
  • Dirk R. Larson, MS

      Affiliations

    • Division of Biostatistics, Mayo Clinic, Rochester, Minn
  • ,
  • Morie A. Gertz, MD

      Affiliations

    • Division of Hematology, and Division of Anatomic Pathology, Mayo Clinic, Rochester, Minn.
  • ,
  • William D. Edwards, MD

References 

  1. Gertz MA , Kyle RA . Amyloidosis (prognosis and treatment) . Semin Arthritis Rheum. . 1994;24:124–138
  2. Gertz MA , Kyle RA . Primary systemic amyloidosis (a diagnostic primer) . Mayo Clin Proc. . 1989;64:1505–1519
  3. Palladini G , Malamani G , Co F , et al.   Holter monitoring in AL amyloidosis (prognostic implications) . Pacing Clin Electrophysiol. . 2001;24:1228–1233
  4. Dubrey SW , Bilazarian S , LaValley M , Reisinger J , Skinner M , Falk RH . Signal-averaged electrocardiography in patients with AL (primary) amyloidosis . Am Heart J. . 1997;134:994–1001
  5. Falk RH , Rubinow A , Cohen AS . Cardiac arrhythmias in systemic amyloidosis (correlation with echocardiographic abnormalities) . J Am Coll Cardiol. . 1984;3:107–113
  6. Lindholm PF , Wick MR . Isolated cardiac amyloidosis associated with sudden death . Arch Pathol Lab Med. . 1986;110:243–245
  7. Mathew V , Olson LJ , Gertz MA , Hayes DL . Symptomatic conduction system disease in cardiac amyloidosis . Am J Cardiol. . 1997;80:1491–1492
  8. Matoba R , Shikata I , Iwai K , et al.   An epidemiologic and histopathological study of sudden cardiac death in Osaka Medical Examiner’s Office . Jpn Circ J. . 1989;53:1581–1588
  9. Pandolfi C , Sbalzarini G , Filippi C . Primary amyloidosis (a case report) . Minerva Med. . 1990;81:319–322 [Japanese]
  10. Reisinger J , Dubrey SW , LaValley M , Skinner M , Falk RH . Electrophysiologic abnormalities in AL (primary) amyloidosis with cardiac involvement . J Am Coll Cardiol. . 1997;30:1046–1051
  11. Skadberg BT , Bruserud O , Karwinski W , Ohm OJ . Sudden death caused by heart block in a patient with multiple myeloma and cardiac amyloidosis . Acta Med Scand. . 1988;223:379–383
  12. Yamaguchi J , Shikano Y , Sato S , Shimamoto K . A clinical and pathological study of 46 cases of sudden and unexpected death [Japanese] . Nippon Ronen Igakkai Zasshi. . 1995;32:722–727
  13. Yang CW , Chun HK , Oh YS , et al.   Torsade de pointes and sudden death in a patient with amyloidosis-associated nephropathy . [letter] Nephron. . 1995;70:499
  14. Mueller PS , Edwards WD , Gertz MA . Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis . Am J Med. . 2000;109:181–188
  15. Gertz MA , Kyle RA , Griffing WL , Hunder GG . Jaw claudication in primary systemic amyloidosis . Medicine (Baltimore) . 1986;65:173–179
  16. Roberts WC , Waller BF . Cardiac amyloidosis causing cardiac dysfunction (analysis of 54 necropsy patients) . Am J Cardiol. . 1983;52:137–146
  17. Salvarani C , Gabriel SE , Gertz MA , Bjornsson J , Li CY , Hunder GG . Primary systemic amyloidosis presenting as giant cell arteritis and polymyalgia rheumatica . Arthritis Rheum. . 1994;37:1621–1626
  18. Thibault GE . Rare x rare . N Engl J Med. . 1992;327:714–717
  19. Wright JR , Calkins E . Clinical-pathologic differentiation of common amyloid syndromes . Medicine (Baltimore) . 1981;60:429–448
  20. Smith RR , Hutchins GM . Ischemic heart disease secondary to amyloidosis of intramyocardial arteries . Am J Cardiol. . 1979;44:413–417
  21. Saffitz JE , Sazama K , Roberts WC . Amyloidosis limited to small arteries causing angina pectoris and sudden death . Am J Cardiol. . 1983;51:1234–1235
  22. Saltissi S , Kertes PJ , Julian DG . Primary cardiac amyloidosis in a young man presenting with angina pectoris . Br Heart J. . 1984;52:233–236
  23. Barbour DJ , Roberts WC . Frequency of acute and healed myocardial infarcts in fatal cardiac amyloidosis . Am J Cardiol. . 1988;62:1134–1135
  24. Petersen EC , Engel JA , Radio SJ , Canfield TM , McManus BM . The clinical problem of occult cardiac amyloidosis (forensic implications) . Am J Forensic Med Pathol. . 1992;13:225–229
  25. Yamano S , Motomiya K , Akai Y , et al.   Primary systemic amyloidosis presenting as angina pectoris due to intramyocardial coronary artery involvement (a case report) . Heart Vessels . 2002;16:157–160
  26. Al Suwaidi J , Velianou JL , Gertz MA , Cannon RO , Higano ST , Holmes DR . Systemic amyloidosis presenting with angina pectoris . Ann Intern Med. . 1999;131:838–841
  27. Alpert JS , Thygesen K , Antman E , Bassand JP . Myocardial infarction redefined (a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction) . J Am Coll Cardiol. . 2000;36:959–969 (Erratum in: J Am Coll Cardiol. 2001;37:973)
  28. Braunwald E , Antman EM , Beasley JW , et al.  American College of Cardiology  American Heart Association  Committee on the Management of Patients With Unstable Angina   ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myoardial infarction—summary article (a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina)) . J Am Coll Cardiol. . 2002;40:1366–1374
  29. Gibbons RJ , Abrams J , Chatterjee K , et al.  American College of Cardiology  American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina)   ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—summary article (a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina)) . J Am Coll Cardiol. . 2003;41:159–168
  30. Edwards WD . Pathology of myocardial infarction and reperfusion . In:  Gersh BJ ,  Rahimtoola SH editor. Acute Myocardial Infarction . New York, New York: Chapman & Hall; 1997;p. 16–50
  31. Crotty TB , Li C-Y , Edwards WD , Suman VJ . Amyloidosis and endomyocardial biopsy (correlation and extent and pattern of deposition with amyloid immunophenotype in 100 cases) . Cardiovasc Pathol. . 1995;4:39–42
  32. Walley VM , Kisilevsky R , Young ID . Amyloid and the cardiovascular system (a review of pathogenesis and pathology with clinical correlations) . Cardiovasc Pathol. . 1995;4:79–102
  33. Pomerance A , Slavin G , McWatt J . Experience with the sodium sulphate-Alcian Blue stain for amyloid in cardiac pathology . J Clin Pathol. . 1976;29:22–26
  34. Moyssakis I , Triposkiadis F , Rallidis L , Hawkins P , Kyriakidis M , Nihoyannopoulos P . Echocardiographic features of primary, secondary and familial amyloidosis . Eur J Clin Invest. . 1999;29:484–489
  35. Smith TJ , Kyle RA , Lie JT . Clinical significance of histopathologic patterns of cardiac amyloidosis . Mayo Clin Proc. . 1984;59:547–555
  36. Olson LJ , Gertz MA , Edwards WD , et al.   Senile cardiac amyloidosis with myocardial dysfunction (diagnosis by endomyocardial biopsy and immunohistochemistry) . N Engl J Med. . 1987;317:738–742
  37. Kyle RA , Spittell PC , Gertz MA , et al.   The premortem recognition of systemic senile amyloidosis with cardiac involvement . Am J Med. . 1996;101:395–400
  38. Ishikawa Y , Ishii T , Masuda S , et al.   Myocardial ischemia due to vascular systemic amyloidosis (a quantitative analysis of autopsy findings on stenosis of the intramural coronary arteries) . Pathol Int. . 1996;46:189–194
  39. Hongo M , Yamamoto H , Kohda T , et al.   Comparison of electrocardiographic findings in patients with AL (primary) amyloidosis and in familial amyloid polyneuropathy and anginal pain and their relation to histopathologic findings . Am J Cardiol. . 2000;85:849–853
  40. Cantwell RV , Aviles RJ , Bjornsson J , et al.   Cardiac amyloidosis presenting with elevations of cardiac troponin I and angina pectoris . Clin Cardiol. . 2002;25:33–37

PII: S0002-9343(05)00448-1

doi: 10.1016/j.amjmed.2005.06.017

The American Journal of Medicine
Volume 118, Issue 11 , Pages 1287.e1-1287.e7 , November 2005