The American Journal of Medicine
Volume 118, Issue 11 , Pages 1287.e9-1287.e16 , November 2005

Use of N-terminal pro-B-type natriuretic peptide to detect myocardial ischemia

  • Daniel Staub, MD

      Affiliations

    • Department of Internal Medicine, Basel, Switzerland
  • ,
  • Nils Jonas, MD

      Affiliations

    • Department of Internal Medicine, Basel, Switzerland
  • ,
  • Michael J. Zellweger, MD

      Affiliations

    • Division of Cardiology, Basel, Switzerland
  • ,
  • Charly Nusbaumer, PhD

      Affiliations

    • Department of Laboratory Medicine, Basel, Switzerland
  • ,
  • Damian Wild, MD

      Affiliations

    • Department of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
  • ,
  • Matthias E. Pfisterer, MD

      Affiliations

    • Division of Cardiology, Basel, Switzerland
  • ,
  • Jan Mueller-Brand, MD

      Affiliations

    • Department of Nuclear Medicine, University Hospital Basel, Basel, Switzerland
  • ,
  • André P. Perruchoud, MD

      Affiliations

    • Department of Internal Medicine, Basel, Switzerland
  • ,
  • Christian Mueller, MD

      Affiliations

    • Department of Internal Medicine, Basel, Switzerland
    • Corresponding Author InformationRequests for reprints should be addressed to Dr. Christian Müller, Medizinische Klinik A, Universitätsklinik, Petersgraben 4, CH-4031 Basel, Switzerland

References 

  1. Braunwald E , Antman EM , Beasley JW , et al.   ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction (executive summary and recommendations) . A report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee on the management of patients with unstable angina). Circulation . 2000;102:1193–1209
  2. Greenland P , Gaziano JM . Clinical practice (Selecting asymptomatic patients for coronary computed tomography or electrocardiographic exercise testing) . N Engl J Med . 2003;349:465–473
  3. Maisel AS , Krishnaswamy P , Nowak RM , et al.  Breathing Not Properly Multinational Study Investigators   Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure . N Engl J Med . 2002;347:161–167
  4. Davis M , Espiner E , Richards G , et al.   Plasma brain natriuretic peptide in assessment of acute dyspnea . Lancet . 1994;343:440–444
  5. Lainchbury JG , Campbell E , Frampton CM , et al.   Brain natriuretic peptide and N-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath . J Am Coll Cardiol . 2003;42:728–735
  6. Wright SP , Doughty RN , Pearl A , et al.   Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care (A randomized, controlled trial) . J Am Coll Cardiol . 2003;42:1793–1800
  7. Svendstrup Nielsen L , Svanegaard J , Klitgaard NA , Egeblad H . N-terminal pro-brain natriuretic peptide for discriminating between cardiac and non-cardiac dyspnoea . Eur Heart J . 2004;6:63–70
  8. Mueller C , Scholer A , Laule-Kilian K , et al.   Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea . N Engl J Med . 2004;350:647–654
  9. Hunt PJ , Richards AM , Nicholls MG , et al.   Immunoreactive aminoterminal pro-brain natriuretic peptide (NT-PROBNP) (a new marker of cardiac impairment) . Clin Endocrinol . 1997;47:287–296
  10. Hunt PJ , Espiner EA , Nicholls MG , et al.   The role of the circulation in processing pro-brain natriuretic peptide (proBNP) to amino-terminal BNP and BNP-32 . Peptides . 1997;18:1475–1481
  11. Tateishi J , Masutani M , Ohyanagi M , et al.   Transient increase in plasma brain (B-type) natriuretic peptide after percutaneous transluminal coronary angioplasty . Clin Cardiol . 2000;23:776–780
  12. Marie PY , Mertes PM , Hassan-Sebbag N , et al.   Exercise release of cardiac natriuretic peptides is markedly enhanced when patients with coronary artery disease are treated medically by beta-blockers . J Am Coll Cardiol . 2004;43:353–359
  13. Asada J , Tsuji H , Iwasaka T , Thomas JD , Lauer MS . Usefulness of plasma brain natriuretic peptide levels in predicting dobutamine-induced myocardial ischemia . Am J Cardiol. . 2004;93:702–704
  14. Bibbins-Domingo K , Ansari M , Schiller NB , Massie B , Whooley MA . B-type natriuretic peptide and ischemia in patients with stable coronary disease (data from the Heart and Soul study) . Circulation . 2003;108:2987–2992
  15. Marumoto K , Hamada M , Hiwada K . Increased secretion of atrial and brain natriuretic peptides during acute myocardial ischaemia induced by dynamic exercise in patients with angina pectoris . Clin Sci . 1995;88:551–556
  16. Nicholson S , Richards M , Espiner E , Nicholls G , Yandle T . Atrial and brain natriuretic peptide response to exercise in patients with ischemic heart disease . Clin Exp Pharmacol Physiol. . 1993;20:535–540
  17. Weber M , Dill T , Arnold R , et al.   N-terminal B-type natriuretic peptide predicts extent of coronary artery disease and ischemia in patients with stable angina pectoris . Am Heart J . 2004;148:612–620
  18. Foote RS , Pearlman JD , Siegel AH , Yeo KTJ . Detection of exercise-induced ischemia by changes in B-type natriuretic peptides . J Am Coll Cardiol . 2004;44:1980–1987
  19. Sabatine MS , Morrow DA , deLemos JA , et al.   Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia . J Am Coll Cardiol . 2004;44:1988–1995
  20. Berman DS , Hosen K , Friedman JD , et al.   Separate acquisition rest thallium-201/stress technetium-99m sestamibi dual-isotope myocardial perfusion single-photon emission computed tomography (a clinical validation study) . J Am Coll Cardiol . 1993;22:1455–1464
  21. Hachamovitch R , Berman DS , Kiat H , et al.   Exercise myocardial perfusion SPECT in patients without known coronary artery disease (incremental prognostic value and use in risk stratification) . Circulation . 1996;93:905–914
  22. Hachamovitch R , Berman DS , Shaw LJ , et al.   Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death (differential stratification for risk of cardiac death and myocardial infarction) . Circulation . 1998;97:535–543
  23. Karl J , Borgya A , Gallusser A , et al.   Development of a novel, N-terminal-proBNP (NT-proBNP) assay with a low detection limit . Scand J Clin Lab Invest . 1999;230(suppl):177–181
  24. Cockcroft DW , Gault MH . Prediction of creatinine clearance from serum creatinine . Nephron . 1976;16:31–41
  25. Mottram PM , Haluska BA , Marwick TH . Response of B-type natriuretic peptide to exercise in hypertensive patients with suspected diastolic heart failure (correlation with cardiac function, hemodynamics, and workload) . Am Heart J . 2004;148:365–370
  26. De Bruyne B , Bronzwaer JG , Heyndrickx GR , Paulus WJ . Comparative effects of ischemia and hypoxemia on left ventricular systolic and diastolic function in humans . Circulation . 1993;88:461–471
  27. Mueller C , Rudez R , Scholer A , Pargger H . Sympathetic outflow and release of B-type natriuretic peptide . Kardiovaskuläre Medizin . 2003;6(suppl 5):83S
  28. Michaelidis AP , Psomadaki ZD , Dilaveris PE , et al.   Improved detection of coronary artery disease by exercise electrocardiography with the use of right precordial leads . N Engl J Med . 1999;340:340–345
  29. Gianrossi R , Detrano R , Mulvihill D , et al.   Exercise-induced ST depression in the diagnosis of coronary artery disease (a meta-analysis) . Circulation . 1989;80:87–98
  30. Morise AP , Diamond GA . Comparison of the sensitivity and specificity of exercise electrocardiography in biased and unbiased populations of men and women . Am Heart J. . 1995;130:741–747
  31. White CW , Wright CB , Doty DB , et al.   Does visual interpretation of the coronary arteriogram predict the physiologic importance of a coronary stenosis? . N Engl J Med . 1984;310:819–824
  32. Pijls NHJ , De Bruyne B , Peels K , et al.   Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses . N Engl J Med . 1996;334:1703–1708

 This study was supported by research grants from the Swiss National Science Foundation, and the Swiss Heart Foundation

PII: S0002-9343(05)00398-0

doi: 10.1016/j.amjmed.2005.05.020

The American Journal of Medicine
Volume 118, Issue 11 , Pages 1287.e9-1287.e16 , November 2005