The American Journal of Medicine
Volume 118, Issue 11 , Pages 1271-1278 , November 2005

Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications

  • Kam-Chuen Lai, MD

      Affiliations

    • Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
    • Corresponding Author InformationRequests for reprints should be addressed to K. C. Lai, MD, Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong, China.
    • ,
  • Kent-Man Chu (FRCS)

      Affiliations

    • Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
    • ,
  • Wai-Mo Hui, MD

      Affiliations

    • Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
    • ,
  • Benjamin Chun-Yu Wong, MD

      Affiliations

    • Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
    • ,
  • Wayne Hsing-Ching Hu, MRCP

      Affiliations

    • Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
    • ,
  • Wai-Man Wong, MD

      Affiliations

    • Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
    • ,
  • Annie On-On Chan, MD

      Affiliations

    • Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
    • ,
  • John Wong (FRCS)

      Affiliations

    • Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
    • ,
  • Shiu-Kum Lam, MD

      Affiliations

    • Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

Received 31 December 2004 ,Accepted 5 April 2005.

References 

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  3. Lai KC , Lam SK , Chu KM , et al.   Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use . N Engl J Med. . 2002;346:2033–2038
  4. Chan FK , Chung SC , Suen BY , et al.   Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen . N Engl J Med. . 2001;344:967–973
  5. Bombardier C , Laine L , Reicin A , et al.  VIGOR Study Group   Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group . N Engl J Med. . 2000;343:1520–1528
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  10. Hui WM , Lam SK , Ho J , et al.   Effect of omeprazole on duodenal ulcer-associated antral gastritis and Helicobacter pylori . Dig Dis Sci. . 1991;36:577–582
  11. Graham DY , Agrawal NM , Campbell DR , et al.  NSAID-Associated Gastric Ulcer Prevention Study Group   Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs (results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole) . Arch Intern Med. . 2002;162:169–175
  12. Chan FK , Hung LC , Suen BY , et al.   Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis . N Engl J Med.. . 2002;347:2104–2110
  13. Hawkey CJ , Yeomans ND , Jones R , et al.   Esomeprazole improves quality of life in patients with upper GI symptoms associated with long-term NSAID therapy . Gastroenterology. . 2003;124:A107; [Abstract]
  14. Bresalier RS , Sandler RS , Quan H , et al.  Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators   Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial . N Engl J Med. . 2005;352:1092–1102
  15. Solomon SD , McMurray JJ , Pfeffer MA , et al.  Adenoma Prevention with Celecoxib (APC) Study Investigators   Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention . N Engl J Med. . 2005;352(11):1071–1080
  16. Wilcox CM , Alexander LN , Cotsonis GA , Clark WS . Nonsteroidal anti-inflammatory drugs are associated with both upper and lower gastrointestinal bleeding . Dig Dis Sci. . 1997;42:990–997
  17. Aldoori WH , Giovannucci EL , Rimm EB , Wing AL , Willett WC . Use of acetaminophen and nonsteroidal anti-inflammatory drugs (a prospective study and the risk of symptomatic diverticular disease in men) . Arch Fam Med. . 1998;7:255–260

 The study was supported by Peptic Ulcer Research Fund and Simon K.Y. Lee Gastroenterology Research Fund of the University of Hong Kong.

PII: S0002-9343(05)00359-1

doi: 10.1016/j.amjmed.2005.04.031

The American Journal of Medicine
Volume 118, Issue 11 , Pages 1271-1278 , November 2005

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