The American Journal of Medicine
Volume 118, Issue 10 , Pages 1142-1147 , October 2005

Are we giving too much iron? Low-dose iron therapy is effective in octogenarians

References 

  1. Hallberg L . Bioavailability of dietary iron in man . Annu Rev Nutr . 1981;1:123–147
  2. Conrad ME , Umbreit JN , Moore EG . Iron absorption and transport . Am J Med Sci . 1999;318:213–229
  3. Fairbanks VF , Beutler E . Iron deficiency . In:  Beutler E ,  Coller BS ,  Lichtman MA ,  Kipps TJ editor. Williams textbook of Hematology . 6th ed. New York: McGraw-Hill; 2001;p. 460–462
  4. Bastani B , Islam S , Boroujerdi N . Iron absorption after single pharmacological oral iron loading test in patients on chronic peritoneal dialysis and in healthy volunteers . Perit Dial Int. . 2000;20:662–666
  5. Marx JJ . Normal iron absorption and decreased red cell uptake in the aged . Blood . 1979;53:204–211
  6. Iron . In:  Sweetman SC editors. Martindale . 33rd ed. London: Pharmaceutical Press; 2002;p. 1366–1368
  7. Barton JC , Barton EH , Bertoli LF , Gothard CH , Serrer JS . Intravenous iron dextran therapy in patients with iron deficiency and normal renal function who failed to respond or did not tolerate oral iron supplementation . Am J Med . 2000;109:27–32
  8. Muretto P , Angelucci E , Lucarelli G . Reversibility of cirrhosis in patients cured of thalassemia by bone marrow transplantation . Ann Intern Med . 2002;136:667–672
  9. Klipstein-Grobusch K , Koster JF , Grobbee DE , et al.   Serum ferritin and risk of myocardial infarction in the elderly (the Rotterdam Study) . Am J Clin Nutr . 1999;69:1231–1236
  10. Jiang R , Manson JE , Meigs JB , Ma J , Rifai N , Hu FB . Body iron stores in relation to risk of type 2 diabetes in apparently healthy women . JAMA . 2004;291:711–717
  11. Montgomery EB . Heavy metals and the etiology of Parkinson’s disease and other movement disorders . Toxicology . 1995;97:3–9
  12. de Sousa M , Porto G . The immunological system in hemochromatosis . J Hepatol . 1998;28(Suppl 1):1–7
  13. WHO/FAO/IAEA . Trace elements in human nutrition and health . Geneva: World Health Organization; 1996;
  14. Crosby WH , O’Neil-Cutting MA . A small dose iron tolerance test as an indicator of mild iron deficiency . JAMA . 1984;251:1986–1987
  15. Joosten E , Vander-Elst B , Billen J . Small-dose iron absorption test in anemia and non-anemia elderly hospitalized patients . Eur J Haematol . 1997;58:99–103
  16. Makrides M , Crowther CA , Gibson RA , Gibson RS , Skeaff CM . Efficacy and tolerability of low-dose iron supplements during pregnancy (a randomized controlled trial) . Am J Clin Nutr . 2003;78:145–153
  17. Massey AC . Microcytic anemia. Differential diagnosis and management of iron deficiency anemia . Med Clin North Am . 1992;76:549–566
  18. Guaytt GH , Patterson C , Ali M , et al.   Diagnosis of iron-deficiency anemia in the elderly . J Gen Intern Med . 1992;7:145–153
  19. Ioannou GN , Spector J , Scott K , Rockey DC . Prospective evaluation of a clinical guideline for the diagnosis and management of iron-deficiency anemia . Am J Med . 2002;113:281–287
  20. Kerr DN , Davidson S . Gastrointestinal intolerance to oral iron preparations . Lancet . 1958;2:489–492
  21. Hallberg L , Ryttinger L , Solvell L . Side-effects of oral iron therapy. A double-blind study of different iron compounds in tablet form . Acta Med Scand Suppl . 1966;459:3–10
  22. Coplin M , Schuette S , Leichtmann G , Lashner B . Tolerability of iron (a comparison of bis-glycino iron II and ferrous sulfate) . Clin Ther . 1991;13:606–612
  23. Frykman E , Bystrom M , Jansson U , Edberg A , Hansen T . Side effects of iron supplements in blood donors (superior tolerance of heme iron) . J Lab Clin Med . 1994;123:561–564
  24. Rimon E , Levi S , Sapir A , Geltzer G , Peled R , Sthoeger Z . Diagnosis of iron deficiency anemia in the elderly by serum transferin receptor . Arch Int Med . 2002;162:445–449

PII: S0002-9343(05)00210-X

doi: 10.1016/j.amjmed.2005.01.065

The American Journal of Medicine
Volume 118, Issue 10 , Pages 1142-1147 , October 2005

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