The American Journal of Medicine
Volume 118, Issue 9 , Pages 1004-1009 , September 2005

White blood cell count and the incidence of ischemic stroke in coronary heart disease patients

  • Nira Koren-Morag, PhD

      Affiliations

    • Division of Epidemiology, Sackler Medical faculty, Tel Aviv University, Israel.
    • Stroke Unit, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.
  • ,
  • David Tanne, MD

      Affiliations

    • Division of Epidemiology, Sackler Medical faculty, Tel Aviv University, Israel.
    • Stroke Unit, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.
  • ,
  • Uri Goldbourt, PhD

      Affiliations

    • Division of Epidemiology, Sackler Medical faculty, Tel Aviv University, Israel.
    • Stroke Unit, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.
    • Corresponding Author InformationRequests for reprints should be addressed to Uri Goldbourt, PhD, Professor of Epidemiology, Sackler Medical Faculty, Tel Aviv University, Tel Aviv 69978, Israel.

References 

  1. Sweetnam PM , Thomas HF , Yarnell JW , et al.   Total and differential leukocyte counts as predictors of ischemic heart disease (the Caerphilly and Speedwell studies) . Am J Epidemiol . 1997;145:415–421
  2. Prentice RL , Szatrowski TP , Fujikura T , et al.   Leukocyte counts and coronary heart disease in a Japanese cohort . Am J Epidemiol . 1982;116:496–509
  3. Gillum RF , Ingram DD , Makuc DML . White blood cell count, coronary heart disease, and death (the NHANES I Epidemiology Follow-up Study) . Am Heart J . 1993;125:855–863
  4. Phillips AN , Neaton JD , Cook DG , et al.   Leukocyte count and risk of major coronary heart disease events . Am J Epidemiol . 1992;136:59–70
  5. Weijenberg MP , Feskens EJ , Kromhout DL . White blood cell count and the risk of coronary heart disease and all-cause mortality in elderly men . Arterioscler Thromb Vasc Biol . 1996;16:499–503
  6. Yaenell JW , Baker IA , Sweetnam PM , et al.   Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease. The Caerphilly and Speedwell collaborative heart disease studies . Circulation . 1991;83:836–844
  7. Kannel WB , Anderson K , Wilson PWL . White blood cell count and cardiovascular disease. Insights from the Framingham Study . JAMA . 1992;267:1253–1256
  8. Adeniyi A , Folsom AR , Brancati FL , et al.   Incidence and risk factors for cardiovascular disease in African Americans with diabetes (the Atherosclerosis Risk in Communities (ARIC) study) . J Natl Med Assoc . 2002;94:1025–1035
  9. Brown DW , Giles WH , Croft JB . White blood cell count (an independent predictor of coronary heart disease mortality among a national cohort) . J Clin Epidemiol . 2001;54:316–322
  10. Haim M , Boyko V , Goldbourt U , et al.   Predictive value of elevated white blood cell count in patients with preexisting coronary heart disease (the Bezafibrate Infarction Prevention Study) . Arch Intern Med . 2004;23:433–439
  11. Adeniyi A , Folsom AR , Brancati FL , et al.   Incidence and risk factors for cardiovascular disease in African Americans with diabetes (the Atherosclerosis Risk in Communities (ARIC) study) . J Natl Med Assoc . 2002;94:1025–1035
  12. Lee CD , Folsom AR , Nieto FJ , et al.   White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women (Atherosclerosis Risk in Communities Study) . Am J Epidemiol . 2001;154:758–764
  13. Gillum RF , Ingram DD , Makuc DM . White blood cell count and stroke incidence and death. The NHANES I epidemiologic follow-up study . Am J Epidemiol . 1994;139:894–902
  14. Baker IA , Pickering J , Elwood PC , et al.   Fibrinogen, viscosity and white blood cell count predict myocardial, but not cerebral infarction (evidence from the Caerphilly and Speedwell cohort) . Thromb Haemost . 2002;87:421–425
  15. Pozzilli C , Lenzi GL , Argentino C , et al.   Peripheral white blood cell count in cerebral ischemic infarction . Acta Neurol Scand . 1985;71:396–400
  16. Prentice RL , Szatrowski TP , Kato H , Mason MW . Leukocyte counts and cerebrovascular disease . J Chronic Dis . 1982;35:703–714
  17. Noto D , Barbagallo CM , Cavera G , et al.   Leukocyte count, diabetes mellitus and age are strong predictors of stroke in a rural population in southern Italy (an 8-year follow-up) . Atherosclerosis . 2001;157:225–231
  18. Belch J , McLaren M , Hanslip J , et al.   The white blood cell and plasma fibrinogen in thrombotic stroke. A significant correlation . Int Angiol . 1998;17:120–124
  19. Elkind MS , Cheng J , Boden-Albala B , et al.   Northern Manhattan Stroke Study. Elevated white blood cell count and carotid plaque thickness: the Northern Manhattan Stroke Study . Stroke . 2001;32:842–849
  20. Elkind MS , Sciacca R , Boden-Albala B , et al.   Leukocyte count is associated with aortic arch plaque thickness . Stroke . 2002;33:2587–2592
  21. Albert AA , Beller CJ , Walter JA , et al.   Preoperative high leukocyte count (a novel risk factor for stroke after cardiac surgery) . Ann Thorac Surg . 2003;75:1550–1557
  22. Goldbourt U , Behar S , Reicher-Reiss H , et al.   Rationale and design of a secondary prevention trial of increasing serum HDL cholesterol and reducing triglycerides in patients with clinically manifest atherosclerotic heart disease . Am J Cardiol . 1993;71:909–915
  23. SPSS version 11.0 for winXP (software) . Chicago, IL: SPSS Inc; 2003;
  24. Michael EM , Siu LH . Validation techniques for logistic regression models . Stat Med . 1991;10:1213–1226
  25. Lemeshow S , Hosmer DW . A review of goodness of fit statistics for use in the development of logistic regression models . Am J Epidemiol . 1982;115:92–106
  26. Grau AJ , Buggle F , Becher H , et al.   The association of leukocyte count, fibrinogen and C-reactive protein with vascular risk factors and ischemic vascular diseases . Thromb Res . 1996;82:245–255
  27. Ross R . Atherosclerosis (an inflammatory disease) . N Engl J Med . 1999;340:115–126
  28. Lindsberg PJ , Grau AJ . Inflammation and infections as risk factors for ischemic stroke . Stroke . 2003;34:2518–2532

PII: S0002-9343(05)00205-6

doi: 10.1016/j.amjmed.2005.03.010

The American Journal of Medicine
Volume 118, Issue 9 , Pages 1004-1009 , September 2005