The American Journal of Medicine
Volume 118, Issue 5 , Pages 548-551 , May 2005

Anemia and ischemia: Myocardial injury in patients with gastrointestinal bleeding

  • Fabio Bellotto, MD

      Affiliations

    • Department of Clinical Cardiology, University of Padua, Italy.
    • Corresponding Author InformationRequests for reprints should be addressed to Fabio Bellotto, MD, Department of Cardiology, Padua General Hospital, University of Padua Medical School, Via Giustiniani 2, 35128 Padova, Italy.
    • ,
  • Stefano Fagiuoli, MD

      Affiliations

    • Department of Gastroenterological and Surgical Sciences, University of Padua, Italy.
    • ,
  • Andrea Pavei, MD

      Affiliations

    • Department of Clinical Cardiology, University of Padua, Italy.
    • ,
  • Shawn A. Gregory, MD

      Affiliations

    • Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, University of Padua, Italy.
    • ,
  • Arianna Cati, MD

      Affiliations

    • Department of Clinical Cardiology, University of Padua, Italy.
    • ,
  • Elisabetta Silverj, MD

      Affiliations

    • Department of Gastroenterological and Surgical Sciences, University of Padua, Italy.
    • ,
  • Mario Plebani, MD

      Affiliations

    • Laboratory Medicine, University of Padua, Italy.
    • ,
  • Martina Zaninotto, PhD

      Affiliations

    • Laboratory Medicine, University of Padua, Italy.
    • ,
  • Tommaso Mancuso, MD

      Affiliations

    • Department of Gastroenterological and Surgical Sciences, University of Padua, Italy.
    • ,
  • Sabino Iliceto, MD

      Affiliations

    • Department of Clinical Cardiology, University of Padua, Italy.

References 

  1. Bhatti N , Amoateng-Adjepongg Y , Qamar A , Manthous CA . Myocardial infarction in critically ill patients presenting with gastrointestinal hemorrhage (retrospective analysis of risks and outcomes) . Chest . 1998;114:1137–1142
  2. Emenike E , Srivastava S , Amoateng-Adjepongg Y , et al.   Myocardial infarction complicating gastrointestinal hemorrhage . Mayo Clin Proc . 1999;74:235–241
  3. Cappell MS . A study of the syndrome of simultaneous acute upper gastrointestinal bleeding and myocardial infarction in 36 patients . Am J Gastroenterol . 1995;90:1444–1449
  4. Gostout CJ , Wang KK , Ahlquist DA , et al.   Acute gastrointestinal bleeding (experience of a specialized management team) . J Clin Gastroenterol . 1992;14:260–267
  5. Zeidman A , Fradin Z , Blecher A , et al.   Anemia as a risk factor for ischemic heart disease . Isr Med Assoc J . 2004;6:16–18
  6. Joint European Society of Cardiology, American College of Cardiology Committee . Myocardial infarction redefined—a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for redefinition of myocardial infarction . J Am Coll Cardiol . 2000;36:959–969
  7. Braunwald E , Antman EM , Beasley JW , et al.   The ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction (executive summary and recommendations) . A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina). Circulation . 2000;102:1193–1209
  8. Wu AHB , Ford L . Release of cardiac troponin in acute coronary syndromes (ischemia or necrosis?) . Clin Chim Acta . 1999;284:161–174
  9. Barasch E , Kaushik V , Gupta R , et al.   Elevated cardiac troponin levels do not predict adverse outcomes in hospitalized patients without clinical manifestations of acute coronary syndromes . Cardiology . 2000;93:1–6
  10. Guest TM , Ramanathan AV , Tuteur PG , et al.   Myocardial injury in critically ill patients (a frequent unrecognized complication) . JAMA . 1995;273:1945–1949
  11. Kim WJ , Laterza OF , Hock KG , et al.   Performance of a revised cardiac troponin method that minimized interferences from heterophilic antibodies . Clin Chem . 2002;48:1028–1034
  12. Musso P , Cox I , Vidano E , et al.   Cardiac troponin elevations in chronic renal failure (prevalence and clinical significance) . Clin Biochem . 1999;32:125–130
  13. Frankel WL , Herold DA , Ziegler TW , Fitzgerald RL . Cardiac troponin T is elevated in asymptomatic patients with chronic renal failure . Am J Clin Pathol . 1996;106:118–123
  14. Thiru Y , Pathan N , Bignall S , et al.   A myocardial cytotoxic process is involved in the cardiac dysfunction of meningococcal septic shock . Crit Care Med . 2000;28: 2979-2883
  15. ver Elst KM , Spapen HD , Nguyen DN , et al.   Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock . Clin Chem . 2000;46:650–657
  16. Ammann P , Fehr T , Minder EI , et al.   Elevation of Troponin I in sepsis and septic shock . Intensive Care Med . 2001;27:965–969
  17. Guerrero-Peral AB , Guerrero-Peral AL , Carrascal Y , et al.   Specific markers of myocardial injury in acute stroke . Rev Neurol . 2002;35:901–904
  18. Collinson PO , Hadcocks L , Foo Y , et al.   Cardiac troponins in patients with renal dysfunction . Ann Clin Biochem . 1998;35:380–386
  19. Apple FS , Sharkey SW , Hoeft P , et al.   Prognostic value of serum cardiac Troponin I and T in chronic dialysis patients (a one-year outcomes analysis) . Am J Kidney Dis . 1997;29:399–403
  20. Pateron D , Beyne P , Laperche T , et al.   Elevated circulating cardiac Troponin I in patients with cirrhosis . Hepatology . 1999;29:640–643
  21. Giannitsis E , Müller-Bardorff M , Kurowsky V , et al.   Independent prognostic value of cardiac Troponin T in patients with confirmed pulmonary embolism . Circulation . 2000;102:211
  22. Missov E , Calzolari C , Davy JM , et al.   Cardiac Troponin I in patients with hematologic malignancies . Coron Artery Dis . 1997;8:537–541
  23. Colleran JA , Papademetriou V , Narayan P , et al.   Electrocardiographic abnormalities suggestive of myocardial ischemia during upper gastrointestinal bleeding . Am J Cardiol . 1995;75:312–314
  24. Leung JM , Weiskopf Rb , Feiner J , et al.   Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans . Anesthesiology . 2000;93:1004–1010

PII: S0002-9343(05)00069-0

doi: 10.1016/j.amjmed.2005.01.026

The American Journal of Medicine
Volume 118, Issue 5 , Pages 548-551 , May 2005

Article Tools

* Image Usage & Resolution