The American Journal of Medicine
Volume 118, Issue 3 , Pages 251-258 , March 2005

The incidence of adverse drug events in two large academic long-term care facilities

  • Jerry H. Gurwitz, MD

      Affiliations

    • The Meyers Primary Care Institute, Fallon Foundation, and University of Massachusetts Medical School, Worcester, Massachusetts
    • Corresponding Author InformationRequests for reprints should be addressed to Jerry H. Gurwitz, MD, Meyers Primary Care Institute, Fallon Foundation, and University of Massachusetts Medical School, 630 Plantation Street, Worcester, Massachusetts 01605
    • ,
  • Terry S. Field, DSc

      Affiliations

    • The Meyers Primary Care Institute, Fallon Foundation, and University of Massachusetts Medical School, Worcester, Massachusetts
    • ,
  • James Judge, MD

      Affiliations

    • Masonicare, Wallingford, Connecticut
    • ,
  • Paula Rochon, MD, MPH

      Affiliations

    • Kunin-Lunenfeld Applied Research Unit, Toronto, Ontario, Canada
    • ,
  • Leslie R. Harrold, MD, MPH

      Affiliations

    • The Meyers Primary Care Institute, Fallon Foundation, and University of Massachusetts Medical School, Worcester, Massachusetts
    • ,
  • Cynthia Cadoret

      Affiliations

    • The Meyers Primary Care Institute, Fallon Foundation, and University of Massachusetts Medical School, Worcester, Massachusetts
    • ,
  • Monica Lee, RPh

      Affiliations

    • Kunin-Lunenfeld Applied Research Unit, Toronto, Ontario, Canada
    • ,
  • Kathleen White, RPh

      Affiliations

    • Masonicare, Wallingford, Connecticut
    • ,
  • Jane LaPrino

      Affiliations

    • Masonicare, Wallingford, Connecticut
    • ,
  • Janet Erramuspe-Mainard

      Affiliations

    • Kunin-Lunenfeld Applied Research Unit, Toronto, Ontario, Canada
    • ,
  • Martin DeFlorio, RPh

      Affiliations

    • Masonicare, Wallingford, Connecticut
    • ,
  • Linda Gavendo, RPh

      Affiliations

    • Kunin-Lunenfeld Applied Research Unit, Toronto, Ontario, Canada
    • ,
  • Jill Auger, RPh

      Affiliations

    • The Meyers Primary Care Institute, Fallon Foundation, and University of Massachusetts Medical School, Worcester, Massachusetts
    • ,
  • David W. Bates, MD, MSc

      Affiliations

    • Brigham and Women’s Hospital, Boston, Massachusetts

References 

  1. Gurwitz JH , Field TS , Avorn J , et al.   Incidence and preventability of adverse drug events in nursing homes . Am J Med . 2000;109:87–94
  2. Gurwitz JH , Field TS , Harrold LR , et al.   Incidence and preventability of adverse drug events among older persons in the ambulatory setting . JAMA . 2003;289:1107–1116
  3. Bates DW , Cullen DJ , Laird N , et al.   Incidence of adverse drug events and potential adverse drug events implications for prevention. ADE Prevention Study Group . JAMA . 1995;274:29–34
  4. Leape LL , Bates DW , Cullen DJ , et al.   Systems analysis of adverse drug events . JAMA . 1995;274:35–43
  5. Leape LL , Cullen DJ , Clapp MD , et al.   Pharmacist participation on physician rounds and adverse drug events in the intensive care unit . JAMA . 1999;282:267–270
  6. Kaushal R , Bates DW , Landrigan C , et al.   Medications errors and adverse drug events in pediatric in-patients . JAMA . 2001;285:2114–2120
  7. Bates DW , Leape LL , Cullen DJ , et al.   Effect of computerized physician order entry and a team intervention on prevention on serious medication errors . JAMA . 1998;280:1311–1316
  8. Bates DW , Spell N , Cullen JJ , et al.   The costs of adverse drug events in hospitalized patients . JAMA . 1997;277:307–311
  9. Freedman VA , Martin LG , Schoeni RF . Recent trends in disability and functioning among older adults in the United States (a systematic review) . JAMA . 2002;288:3137–3146
  10. Sackett DL , Haynes RB , Guyatt GH , Tugwell P . Clinical Epidemiology (A Basic Science for Clinical Medicine) . 2nd ed. Boston, Massachusetts: Little Brown & Co; 1991;
  11. Charlson ME , Pompei P , Ales KL , MacKenzie CR . A new method of classifying prognostic comorbidity in longitudinal studies (development and validation) . J Chronic Dis . 1987;40:373–383
  12. Rosner B . Fundamentals of Biostatistics . 3rd ed. Boston, Massachusetts: PWS-Kent; 1990;
  13. Stata Statistical Software. Release 6.0 . College Station, Texas:: Stata Corp; 1999;
  14. National Nursing Home Survey (NNHS) . 2003; Available at:http://www.cdc.gov/nchs/about/major/nnhsd/nnhsd.htm.Accessed July 18
  15. Kuperman GJ , Gibson RF . Computer physician order entry (benefits, costs, and issues) . Ann Intern Med . 2003;139:31–39
  16. Kaushal R , Shojania KG , Bates DW . Effects of computerized physician order entry and clinical decisions support systems on medication safety . Arch Intern Med . 2003;163:1409–1416
  17. Berwick DM . Errors today and errors tomorrow . N Engl J Med . 2003;348:2570–2572

 Supported by a grant from the Agency for Healthcare Research and Quality (HS010481), Rockville, Maryland.

PII: S0002-9343(04)00718-1

doi: 10.1016/j.amjmed.2004.09.018

The American Journal of Medicine
Volume 118, Issue 3 , Pages 251-258 , March 2005

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